Search Results - "Bruss, Jon B."

The economics of pediatric formulation development for off-patent drugs by Milne, Christopher-Paul, JD, Bruss, Jon B., MD

“…Abstract Background: Many drugs currently used in children have never been adequately studied in rigorous scientific trials. Although these medications can…”
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Pharmacokinetics and Safety of Single and Multiple Doses of ACHN-490 Injection Administered Intravenously in Healthy Subjects by CASS, Robert T, BROOKS, Carter D, HAVRILLA, Nancy A, TACK, Kenneth J, BORIN, Marie T, DON YOUNG, BRUSS, Jon B

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Hematologic Effects of Linezolid: Summary of Clinical Experience by GERSON, Stanton L, KAPLAN, Sheldon L, BRUSS, Jon B, LE, Vu, ARELLANO, Felix M, HAFKIN, Barry, KUTER, David J

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Lack of Evidence Associating Nephrotoxicity with Low-Dose Gentamicin for Staphylococcus aureus Bacteremia and Endocarditis by Bruss, Jon B.

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Safety and pharmacokinetics of SPR206 in subjects with varying degrees of renal impairment by Bruss, Jon B, Bader, Justin, Hamed, Kamal A

“…SPR206 is a novel polymyxin derivative with potent activity against susceptible and multidrug-resistant strains of , , , , and species. SPR206 is eliminated…”
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Pharmacokinetics of SPR206 in Plasma, Pulmonary Epithelial Lining Fluid, and Alveolar Macrophages following Intravenous Administration to Healthy Adult Subjects by Rodvold, Keith A, Bader, Justin, Bruss, Jon B, Hamed, Kamal

“…SPR206 is a next-generation polymyxin being developed for the treatment of multidrug-resistant (MDR) Gram-negative infections. This Phase 1 bronchoalveolar…”
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Linezolid versus vancomycin for treatment of resistant Gram-positive infections in children by KAPLAN, SHELDON L, DEVILLE, JAIME G, YOGEV, RAM, MORFIN, MA RAYO, WU, ELBA, ADLER, STUART, EDGE-PADBURY, BARBARA, NABERHUIS-STEHOUWER, SHARON, BRUSS, JON B

“…BACKGROUND.Pediatric infections caused by resistant Gram-positive infections are an increasing concern with limited treatment options. Linezolid, a new…”
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Randomized Comparison of Linezolid (PNU-100766) versus Oxacillin-Dicloxacillin for Treatment of Complicated Skin and Soft Tissue Infections by Stevens, D L, Smith, L G, Bruss, J B, McConnell-Martin, M A, Duvall, S E, Todd, W M, Hafkin, B

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Linezolid for the treatment of methicillin-resistant Staphylococcus aureus infections in children by KAPLAN, SHELDON L, AFGHANI, BEHNOOSH, LOPEZ, PIO, WU, ELBA, FLEISHAKER, DONA, EDGE-PADBURY, BARBARA, NABERHUIS-STEHOUWER, SHARON, BRUSS, JON B

“…BACKGROUND.Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are becoming increasingly prevalent. Linezolid is effective and…”
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Hematologic effects of linezolid in young children by MEISSNER, H CODY, TOWNSEND, TIMOTHY, WENMAN, WANDA, KAPLAN, SHELDON L, MORFIN, MARIA RAYO, EDGE-PADBURY, BARBARA, NABERHUIS-STEHOUWER, SHARON, BRUSS, JON B

“…BACKGROUND.Linezolid is an effective and well-tolerated antibiotic for the treatment of Gram-positive infections, including hospital and community-acquired…”
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Source Control Review in Clinical Trials of Anti-Infective Agents in Complicated Intra-Abdominal Infections by Solomkin, Joseph S., Ristagno, Ross L., Das, Anita F., Cone, John B., Wilson, Samuel E., Rotstein, Ori D., Murphy, Brian S., Severin, Kimberley S., Bruss, Jon B.

“…In clinical trials of complicated intra-abdominal infections, assessment of adequacy of the initial surgical approach to the management of the infection is of…”
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Telavancin in the Treatment of Concurrent Staphylococcus aureus Bacteremia: A Retrospective Analysis of ATLAS and ATTAIN Studies by Wilson, Samuel E., Graham, Donald R., Wang, Whedy, Bruss, Jon B., Castaneda-Ruiz, Bibiana

“…Introduction Concurrent Staphylococcus aureus bacteremia (SAB) worsens outcomes and increases mortality in patients with complicated skin and skin structure…”
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Treatment of severe pertussis: a study of the safety and pharmacology of intravenous pertussis immunoglobulin by BRUSS, JON B, MALLEY, RICHARD, HALPERIN, SCOTT, DOBSON, SIMON, DHALLA, MOHSIN, MCIVER, JAMES, SIBER, GEORGE R

“…BACKGROUND.Pertussis in infants is often severe, resulting in complications and prolonged hospitalization. Treatment is limited to supportive care. Antibiotics…”
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Quantitative Priming with Inactivated Pertussis Toxoid Vaccine in the Aerosol Challenge Model by BRUSS, Jon B, SIBER, George R

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A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder by Handen, Benjamin L., Melmed, Raun D., Hansen, Robin L., Aman, Michael G., Burnham, David L., Bruss, Jon B., McDougle, Christopher J.

“…Controversy exists regarding the extent and possible causal relationship between gastrointestinal symptoms and autism. A randomized, double-blind,…”
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Linezolid versus vancomycin in the treatment of known or suspected resistant Gram-positive infections in neonates by DEVILLE, JAIME G, ADLER, STUART, AZIMI, PARVIN H, JANTAUSCH, BARBARA A, MORFIN, MARIA RAYO, BELTRAN, SANDRA, EDGE-PADBURY, BARBARA, NABERHUIS-STEHOUWER, SHARON, BRUSS, JON B

“…BACKGROUND.Gram-positive infections caused by susceptible and resistant strains of Staphylococcus aureus, coagulase-negative staphylococci and enterococci are…”
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Safety and tolerability of linezolid in children by SAIMAN, LISA, GOLDFARB, JOHANNA, KAPLAN, SHELDON A, WIBLE, KENNETH, EDGE-PADBURY, BARBARA, NABERHUIS-STEHOUWER, SHARON, BRUSS, JON B

“…BACKGROUND.Linezolid, an oxazolidinone, is effective in the treatment of adults and children with community-acquired and nosocomial pneumonia and uncomplicated…”
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Linezolid for the treatment of children with bacteremia or nosocomial pneumonia caused by resistant Gram-positive bacterial pathogens by JANTAUSCH, BARBARA A, DEVILLE, JAIME, ADLER, STUART, MORFIN, MARIA RAYO, LOPEZ, PIO, EDGE-PADBURY, BARBARA, NABERHUIS-STEHOUWER, SHARON, BRUSS, JON B

“…BACKGROUND.Nosocomial infections, particularly hospital-acquired pneumonia (HAP) and bacteremia, are an increasing concern in pediatric hospitals and pediatric…”
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Impact of ontogeny on linezolid disposition in neonates and infants by Kearns, Gregory L., Jungbluth, Gail L., Abdel‐Rahman, Susan M., Hopkins, Nancy K., Welshman, Ian R., Grzebyk, Rosie P., Bruss, Jon B., Anker, John N.

“…The impact of age on linezolid disposition during the first few months of life has not been previously investigated. We characterized linezolid…”
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Linezolid for the treatment of complicated skin and skin structure infections in children by YOGEV, RAM, PATTERSON, LORI E, KAPLAN, SHELDON L, ADLER, STUART, MORFIN, MARIA RAYO, MARTIN, AMANDO, EDGE-PADBURY, BARBARA, NABERHUIS-STEHOUWER, SHARON, BRUSS, JON B

“…BACKGROUND.Gram-positive pathogens are a major cause of complicated skin and skin structure infections (CSSSIs) in children. Many pathogens are developing…”
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