Search Results - "Brunt, Breauna"

ATRT-01. PARP INHIBITION AS A THERAPEUTIC TARGET IN ATRT by Alimova, Irina, Mardok, Gillian, Pierce, Angela, Wang, Dong, Madhavan, Krishna, Brunt, Breauna, Vibhakar, Rajeev

“…Atypical teratoid rhabdoid tumors (ATRTs) are highly aggressive pediatric brain tumors with poor survival. The available treatments rely on toxic chemotherapy…”
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EPEN-08. COMBINED PDGFR INHIBITOR AXITINIB AND RETINOID TRETINOIN DECREASES PROLIFERATION AND HIGH-RISK NEOPLASTIC SUBPOPULATION PROPORTIONS PFA EPENDYMOMA by Donson, Andrew, Grimaldo, Enrique, Riemondy, Kent, Griesinger, Andrea, Amani, Vladimir, Brunt, Breauna, Pierce, Angela, Foreman, Nicholas

“…Ependymoma (EPN) is fatal in over 50% of children and has not seen any therapeutic improvements in over 30 years. Based on data from single-cell RNA sequencing…”
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EPEN-23. TARGETING TRISOMY MDM4 INDUCES CELL DEATH IN 1Q+ PFA EPENDYMOMA THROUGH REACTIVATION OF THE P53 PATHWAY by Calzadilla, Annaliese J, Griesinger, Andrea M, Donson, Andrew M, Grimaldo, Enrique, Madhavan, Krishna, Alimova, Irina, Pierce, Angela M, Brunt, Breauna, Vibhakar, Rajeev, Foreman, Nicholas K

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The PARP inhibitor Rucaparib synergizes with radiation to attenuate atypical teratoid rhabdoid tumor growth by Alimova, Irina, Murdock, Gillian, Pierce, Angela, Wang, Dong, Madhavan, Krishna, Brunt, Breauna, Venkataraman, Sujatha, Vibhakar, Rajeev

“…Abstract Background Atypical teratoid rhabdoid tumors (ATRT) are highly aggressive pediatric brain tumors. The available treatments rely on toxic chemotherapy…”
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Abstract PR010: Developing a safe and potent tumor-targeting gated CAR-T cell therapy for DIPG: A deadly pediatric brain tumor by Venkataraman, Sujatha, Balakrishnan, Ilango, Leach, Lillie, Madhavan, Krishna, Pierce, Angela, Michlin, Joshua, Obrecht, Joshua, Brunt, Breauna, Fry, Terry, Vibhakar, Rajeev, Kohler, Eric M.

“…Background: DIPG (Diffuse Intrinsic Pontine Glioma) is an aggressive pediatric brain tumor that infiltrates the pons and is uniformly fatal. Curative surgery…”
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MRI-guided focused ultrasound blood–brain barrier opening increases drug delivery and efficacy in a diffuse midline glioma mouse model by Martinez, Payton, Nault, Genna, Steiner, Jenna, Wempe, Michael F, Pierce, Angela, Brunt, Breauna, Slade, Mathew, Song, Jane J, Mongin, Andrew, Song, Kang-Ho, Ellens, Nicholas, Serkova, Natalie, Green, Adam L, Borden, Mark

“…Abstract Background Diffuse intrinsic pontine glioma (DIPG) is the most common and deadliest pediatric brainstem tumor and is difficult to treat with…”
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Enhancing Delivery and Efficacy of Panobinostat for Diffuse Midline Glioma through Focused Ultrasound-Mediated Blood-Brain Barrier Opening by Martinez, Payton, Song, Jane J., Song, Kang-Ho, Borden, Mark, Nault, Genna, Steiner, Jenna, Serkova, Natalie, Wempe, Micheal F., Pierce, Angela, Brunt, Breauna, Slade, Mathew, Green, Adam

“…Diffuse midline gliomas (DMG) are one of the most prevalent and deadliest brainstem tumors among children. DMGs present a challenge for chemotherapy due in…”
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