Search Results - "Bruns, Ashley"

Predictive value of oxygenation index for outcomes in left-sided congenital diaphragmatic hernia by Bruns, Ashley S., Lau, Patricio E., Dhillon, Gurpreet S., Hagan, Joseph, Kailin, Joshua A., Mallory, George B., Lohmann, Pablo, Olutoye, Oluyinka O., Ruano, Rodrigo, Fernandes, Caraciolo J.

“…Congenital Diaphragmatic Hernia (CDH) is associated with significant morbidity and mortality. This study compares the efficacy of the highest oxygenation index…”
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Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trial by Paller, Channing J, Zhou, Xian C, Heath, Elisabeth I, Taplin, Mary-Ellen, Mayer, Tina, Stein, Mark N, Bubley, Glenn J, Pili, Roberto, Hudson, Tamaro, Kakarla, Radhika, Abbas, Muneer M, Anders, Nicole M, Dowling, Donna, King, Serina, Bruns, Ashley B, Wagner, William D, Drake, Charles G, Antonarakis, Emmanuel S, Eisenberger, Mario A, Denmeade, Samuel R, Rudek, Michelle A, Rosner, Gary L, Carducci, Michael A

“…MuscadinePlus (MPX), a commercial preparation of pulverized muscadine grape skin, was evaluated as a therapeutic option for men with biochemically recurrent…”
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Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide: an open-label, phase 2, multicohort study by Teply, Benjamin A, Wang, Hao, Luber, Brandon, Sullivan, Rana, Rifkind, Irina, Bruns, Ashley, Spitz, Avery, DeCarli, Morgan, Sinibaldi, Victoria, Pratz, Caroline F, Lu, Changxue, Silberstein, John L, Luo, Jun, Schweizer, Michael T, Drake, Charles G, Carducci, Michael A, Paller, Channing J, Antonarakis, Emmanuel S, Eisenberger, Mario A, Denmeade, Samuel R

“…Prostate cancer that progresses after enzalutamide treatment is poorly responsive to further antiandrogen therapy, and paradoxically, rapid cycling between…”
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Twelve-Year-Old Female With Nausea, Vomiting, Edema, Tremor, and Slurred Speech by Bruns, Ashley Suzanne, Sebestyen, Judith

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Clinical Activity of Single-Agent Cabozantinib (XL184), a Multi-receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Soft-Tissue Sarcomas by O'Sullivan Coyne, Geraldine, Kummar, Shivaani, Hu, James, Ganjoo, Kristen, Chow, Warren A, Do, Khanh T, Zlott, Jennifer, Bruns, Ashley, Rubinstein, Lawrence, Foster, Jared C, Juwara, Lamin, Meehan, Robert, Piekarz, Richard, Streicher, Howard, Sharon, Elad, Takebe, Naoko, Voth, Andrea Regier, Bottaro, Donald, Costello, Rene, Wright, John J, Doroshow, James H, Chen, Alice P

“…Soft-tissue sarcomas (STS) are a rare, heterogeneous group of mesenchymal tumors. For decades the mainstay of treatment for advanced, unresectable STS has been…”
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Phase I trial of 5-aza-4’-thio-2’-deoxycytidine (Aza-TdC) in patients with advanced solid tumors by Nguyen, James, O'Sullivan Coyne, Geraldine Helen, Takebe, Naoko, Naqash, Abdul Rafeh, Mukherjee, Jessica, Bruns, Ashley, Piekarz, Richard, Collins, Jerry M., Anderson, Larry, Miller, Brandon, Parchment, Ralph E., Rubinstein, Larry V, Kummar, Shivaani, Sharon, Elad, Streicher, Howard, Chen, Alice P., Doroshow, James H.

“…Abstract only 3088 Background: The nucleoside analog Aza-TdC inhibits DNA methyltransferase 1 (DNMT1), which regulates methylation-mediated silencing of tumor…”
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Safety, anti-tumor activity, and biomarker analysis in a phase 1 trial of the once-daily Wee1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors by Takebe, Naoko, Naqash, Abdul Rafeh, Coyne, Geraldine O’Sullivan, Kummar, Shivaani, Do, Khanh, Bruns, Ashley, Juwara, Lamin, Zlott, Jennifer, Rubinstein, Larry, Piekarz, Richard, Sharon, Elad, Streicher, Howard, Mittra, Arjun, Miller, Sarah B., Ji, Jiuping, Wilsker, Deborah, Kinders, Robert J., Parchment, Ralph E., Chen, Li, Chang, Ting-Chia, Das, Biswajit, Mugundu, Ganesh, Doroshow, James H., Chen, Alice P.

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Abstract LB-015: Phase I trial of recombinant human interleukin 15 (rhIL-15) in combination with nivolumab and ipilimumab in refractory cancers by Coyne, Geraldine OSullivan, Khan, Sabrina S., Conlon, Kevin, Streicher, Howard, Bruns, Ashley, Piekarz, Richard, Takebe, Naoko, Juwara, Lamin, Parchment, Ralph, Navas, Tony, Fino, Kirstin, Fung, King L., Sharon, Elad, Doroshow, James H., Waldmann, Thomas A., Chen, Alice P.

“…Abstract Introduction: Treatment with rhIL-15 has been reported to significantly increase levels of circulating CD8+ T cells, NK cells, and inflammatory…”
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Safety, Antitumor Activity, and Biomarker Analysis in a Phase I Trial of the Once-daily Wee1 Inhibitor Adavosertib (AZD1775) in Patients with Advanced Solid Tumors by Takebe, Naoko, Naqash, Abdul Rafeh, O'Sullivan Coyne, Geraldine, Kummar, Shivaani, Do, Khanh, Bruns, Ashley, Juwara, Lamin, Zlott, Jennifer, Rubinstein, Larry, Piekarz, Richard, Sharon, Elad, Streicher, Howard, Mittra, Arjun, Miller, Sarah B, Ji, Jiuping, Wilsker, Deborah, Kinders, Robert J, Parchment, Ralph E, Chen, Li, Chang, Ting-Chia, Das, Biswajit, Mugundu, Ganesh, Doroshow, James H, Chen, Alice P

“…The Wee1 kinase inhibitor adavosertib abrogates cell-cycle arrest, leading to cell death. Prior testing of twice-daily adavosertib in patients with advanced…”
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Trial in progress abstract phase I trial of 5-aza-4’-thio-2’-deoxycytidine (Aza-TdC) in patients with advanced solid tumors by Monge B., M. Cecilia, O'Sullivan Coyne, Geraldine Helen, Piekarz, Richard, Takebe, Naoko, Bruns, Ashley, Mittra, Arjun, Khan, Sabrina Sharmin, Collins, Jerry M., Anderson, Larry, Juwara, Lamin, Miller, Brandon, Kinders, Robert J., Rubinstein, Larry, Chen, Alice P., Doroshow, James H.

“…Abstract only TPS3148 Background: The nucleoside analog 5-aza-4’-thio-2’-deoxycytidine (Aza-TdC) inhibits DNA methyltransferase 1 (DNMT1), a methyltransferase…”
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Tumor genomic analysis for biomarker identification in a phase I trial of the Wee 1 inhibitor adavosertib (AZD1775) by Naqash, Abdul Rafeh, Mittra, Arjun, O'Sullivan Coyne, Geraldine Helen, Chen, Li, Das, Biswajit, Kummar, Shivaani, Do, Khanh T, Chang, Ting-Chia, Bruns, Ashley, Juwara, Lamin, Miller, Brandon, Kinders, Robert J., Parchment, Ralph E., Rubinstein, Larry V, Ji, Jiuping Jay, Wilsker, Deborah, Dull, Angie B, Doroshow, James H., Chen, Alice P., Takebe, Naoko

“…Abstract only 3624 Background: Adavosertib, a first-in-class Wee1 kinase inhibitor, abrogates G2/M cell cycle arrest causing premature mitosis and DNA…”
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Phase I study of recombinant interleukin-15 in combination with checkpoint inhibitors nivolumab and ipilimumab in subjects with refractory cancers by O'Sullivan Coyne, Geraldine Helen, Conlon, Kevin, Takebe, Naoko, Streicher, Howard, Quinn, Mary Flanagan, Bruns, Ashley, Navas, Tony, Parchment, Ralph E., Rubinstein, Larry, Sharon, Elad, Doroshow, James H., Waldmann, Thomas A., Chen, Alice P.

“…Abstract only…”
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Abstract CT099: DNA damage response and therapeutic activity following once-daily administration of the Wee 1 inhibitor AZD1775 (adavosertib) by Mittra, Arjun, Coyne, Geraldine O'Sullivan, Kummar, Shivaani, Do, Khanh, Bruns, Ashley, Juwara, Lamin, Piekarz, Richard, Rubinstein, Larry, Prindiville, Sheila, Sharon, Elad, Streicher, Howard, Hsia, Tiffaney, Mugundu, Ganesh, Ji, Jiuping, Wilsker, Deborah, Dull, Angie B., Miller, Brandon, Kinders, Robert J., Parchment, Ralph, Doroshow, James H., Chen, Alice P., Takebe, Naoko

“…Abstract Background: Wee1 tyrosine kinase phosphorylates and inactivates cyclin dependent kinase (Cdk) 1 as part of DNA damage response (DDR) signaling,…”
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Safety and tolerability of veliparib, an oral PARP inhibitor, and M6620 (VX-970), an ATR inhibitor, in combination with cisplatin in patients with refractory solid tumors by Mittra, Arjun, O'Sullivan Coyne, Geraldine Helen, Do, Khanh Tu, Piha-Paul, Sarina Anne, Kummar, Shivaani, Takebe, Naoko, Bruns, Ashley, Juwara, Lamin, Rubinstein, Lawrence, Hogu, Murielle, Kinders, Robert J., Parchment, Ralph E., Miller, Brandon, Wilsker, Deborah, Monge B., M. Cecilia, Khan, Sabrina Sharmin, Doyle, L. Austin, Doroshow, James H., Chen, Alice P.

“…Abstract only 3067 Background: M6620 (M), a potent ATR inhibitor, has synergistic activity with cisplatin (C) in multiple preclinical models, resulting in DNA…”
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Phase II study of bipolar androgen therapy (BAT) in men with metastatic castration-resistant prostate cancer (mCRPC) and progression on enzalutamide (enza) by Teply, Benjamin A., Wang, Hao, Sullivan, Rana, Rifkind, Irina, Bruns, Ashley, Decarli, Morgan, Sinibaldi, Victoria J., Pratz, Caroline F., Luo, Jun, Carducci, Michael Anthony, Paller, Channing Judith, Antonarakis, Emmanuel S., Eisenberger, Mario A., Denmeade, Samuel R.

“…Abstract only 5017 Background: Androgen receptor (AR) overexpression is a common adaptive resistance mechanism in mCRPC. High dose testosterone in this setting…”
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Phase I trial of the triplet M6620 (formerly VX970) + veliparib + cisplatin in patients with advanced solid tumors by O'Sullivan Coyne, Geraldine Helen, Do, Khanh Tu, Kummar, Shivaani, Takebe, Naoko, Quinn, Mary Flanagan, Piha-Paul, Sarina Anne, Bruns, Ashley, Juwara, Lamin, Sharon, Elad, Piekarz, Richard, Streicher, Howard, Rubinstein, Larry, Wilsker, Deborah, Kinders, Robert J., Parchment, Ralph E., Levy, Elliot B, Doyle, Austin, Doroshow, James H., Chen, Alice P.

“…Abstract only…”
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Safety, tolerability, and antitumor activity of once-daily Wee-1 inhibitor AZD1775 by Takebe, Naoko, O'Sullivan Coyne, Geraldine Helen, Kummar, Shivaani, Do, Khanh Tu, Bruns, Ashley, Juwara, Lamin, Quinn, Mary Flanagan, Harris, Lyndsay, Piekarz, Richard, Prindiville, Sheila Ann, Sharon, Elad, Streicher, Howard, Mugundu, Ganesh, Ji, Jiuping Jay, Wilsker, Deborah, Kinders, Robert J., Rubinstein, Larry, Doroshow, James H., Chen, Alice P.

“…Abstract only…”
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Abstract CT115: Safety and efficacy of Anti-PD-L1 antibody MEDI4736 (durvalumab) in combination with capecitabine in patients with advanced solid tumors (DURVA+) by Salkeni, Mohamad Adham, O’Sullivan Coyne, Geraldine, Takebe, Naoko, Sharon, Elad, Streicher, Howard, Mukherjee, Jessica, Bruns, Ashley, Mitra, Arjun, Naqash, Abdul R., Rubinstein, Larry, Fino, Kristin K., Fung, King L., Ferry-Galow, Katherine, Parchment, Ralph, Chen, Helen, Doroshow, James, Chen, Alice

“…Abstract Background: It is hypothesized that chemotherapy alters the tumor microenvironment (TME) by increasing T cell infiltration and enhancing antigen…”
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Abstract CT147: Phase 1 study of recombinant interleukin 15 (rhIL-15) in combination with checkpoint inhibitors nivolumab and ipilimumab in subjects with refractory cancers by Shin, Sarah J., O'Sullivan Coyne, Geraldine, Streicher, Howard, Takebe, Naoko, Bruns, Ashley, Sharon, Elad, Piekarz, Richard, Juwara, Lamin, Rubinstein, Larry, Parchment, Ralph, Fino, Kristin, Fung, King L., Ferry-Galow, Katherine, Mittra, Arjun, Naqash, Abdul Rafeh, Conlon, Kevin, Doroshow, James H., Chen, Alice P.

“…Abstract Introduction: Recombinant human interleukin 15 (rhIL-15) has been shown to stimulate the activation and expansion in the number of effector T…”
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1415A Quality Improvement Initiative to Decrease Unnecessary Streptococcal Antigen Testing in an Urban Pediatric Emergency Department by Bruns, Ashley, Myers, Cameron, Lee, Brian, Gripka, Megan, Shaw, Kristen, Weston, Sarah, Loehr, Andrew, Kleweno, Robyn, Myers, Angela

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