Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene

Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene

We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists...

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Bibliographic Details
Published in:Biochemical and biophysical research communications Vol. 329; no. 4; pp. 1193 - 1199
Main Authors: Zierhut, Barbara, Daneva, Teodora, Gartner, Wolfgang, Brunnmaier, Barbara, Mineva, Ivelina, Berggård, Tord, Wagner, Ludwig
Format: Journal Article
Language:English
Published: United States Elsevier Inc 22-04-2005
Subjects:
Alternative Splicing - genetics
Amino Acid Sequence
Antibodies - immunology
Biologi
Biological Sciences
Calcium - metabolism
Calcium-Binding Proteins - chemistry
Calcium-Binding Proteins - genetics
Calcium-Binding Proteins - metabolism
Cloning, Molecular
DNA, Complementary - genetics
EF-hand calcium binding protein
Escherichia coli - genetics
Humans
Molecular Sequence Data
Natural Sciences
Naturvetenskap
RNA editing
RNA, Messenger - genetics
RNA, Messenger - metabolism
Secretagogin
Secretagogin-R22
Secretagogins
Sequence Alignment
Setagin
Transcription, Genetic - genetics
Secretagogin
RNA editing
Secretagogin-R22
Setagin
EF-hand calcium binding protein
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Summary:We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin. We demonstrate that this protein truncation results in complete loss of the calcium binding capacity. Setagin expression was found in considerable amounts in the pancreas whereas secretagogin and secretagogin-R22 were also found in the central nervous system and organs containing neurendocrine cells.
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ISSN:0006-291X
1090-2104
1090-2104
DOI:10.1016/j.bbrc.2005.02.093