Search Results - "Brunner, HR"

Comparative effects of losartan and irbesartan on serum uric acid in hypertensive patients with hyperuricaemia and gout by Würzner, Grégoire, Gerster, Jean-Charles, Chiolero, Arnaud, Maillard, Marc, Fallab-Stubi, Claire-Lise, Brunner, Hans R, Burnier, Michel

“…OBJECTIVE Losartan has been shown to increase urinary uric acid excretion and hence to lower serum uric acid levels. The purposes of the present study were(1)…”
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Renal hemodynamic and tubular responses to salt in women using oral contraceptives by Pechère-Bertschi, Antoinette, Maillard, Marc, Stalder, Hans, Bischof, Paul, Fathi, Marc, Brunner, Hans R., Burnier, Michel

“…Renal hemodynamic and tubular responses to salt in women using oral contraceptives. The use of oral contraceptives is associated with an increased risk of…”
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Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial by Julius, Stevo, Kjeldsen, Sverre E, Weber, Michael, Brunner, Hans R, Ekman, Steffan, Hansson, Lennart, Hua, Tsushung, Laragh, John, McInnes, Gordon T, Mitchell, Lada, Plat, Francis, Schork, Anthony, Smith, Beverly, Zanchetti, Alberto

“…The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial was designed to test the hypothesis that for the same blood-pressure control, valsartan…”
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Angiotensin II receptor antagonists by Burnier, M, Brunner, HR

“…Blockade of the renin-angiotensin system began as a way of studying the pathogenesis of cardiovascular disease with specific pharmacological probes. Oral…”
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Angiotensin II Suppression in Humans by the Orally Active Renin Inhibitor Aliskiren (SPP100): Comparison With Enalapril by Nussberger, Juerg, Wuerzner, Grégoire, Jensen, Chris, Brunner, Hans R

“…Renin is the main determinant of angiotensin (Ang) II levels. It, therefore, always appeared desirable to reduce Ang II levels by direct inhibition of renin…”
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Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial by Weber, Michael A, Julius, Stevo, Kjeldsen, Sverre E, Brunner, Hans R, Ekman, Steffan, Hansson, Lennart, Hua, Tsushung, Laragh, John H, McInnes, Gordon T, Mitchell, Lada, Plat, Francis, Schork, M Anthony, Smith, Beverly, Zanchetti, Alberto

“…The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial was designed to test whether, for the same achieved blood pressures, regimens based on…”
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Renal effects of selective cyclooxygenase-2 inhibition in normotensive salt-depleted subjects by Rossat, Julien, Maillard, Marc, Nussberger, Jürg, Brunner, Hans R., Burnier, Michel

“…Purpose To compare the renal hemodynamic and tubular effects of celecoxib, a selective inhibitor of cyclooxygenase‐2 (COX‐2) to those of naproxen, a…”
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Endogenous Angiotensin II Induces Atherosclerotic Plaque Vulnerability and Elicits a Th1 Response in ApoE−/− Mice by Mazzolai, Lucia, Duchosal, Michel A, Korber, Martine, Bouzourene, Karima, Aubert, Jean François, Hao, Hiroyuki, Vallet, Veronique, Brunner, Hans-R, Nussberger, Jürg, Gabbiani, Giulio, Hayoz, Daniel

“…Rupture of vulnerable plaques is the main cause of acute cardiovascular events. However, mechanisms responsible for transforming a stable into a vulnerable…”
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Effects of the Peroxisomal Proliferator-Activated Receptor-γ Agonist Pioglitazone on Renal and Hormonal Responses to Salt in Healthy Men by Zanchi, Anne, Chiolero, Arnaud, Maillard, Marc, Nussberger, Jürg, Brunner, Hans-Rudolf, Burnier, Michel

“…Glitazones are used in the treatment of type 2 diabetes as efficient insulin sensitizers. They can, however, induce peripheral edema through an unknown…”
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Electronic compliance monitoring in resistant hypertension: the basis for rational therapeutic decisions by Burnier, Michel, Schneider, Marie Paule, Chioléro, Arnaud, Stubi, Claire Lise Fallab, Brunner, Hans R

“…OBJECTIVEIncomplete compliance is one of several possible causes of uncontrolled hypertension. Yet, non-compliance remains largely unrecognized and is falsely…”
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Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor by Pedrazzini, Thierry, Seydoux, Josiane, Künstner, Pierre, Aubert, Jean-François, Grouzmann, Eric, Beermann, Friedrich, Brunner, Hans R

“…Neuropeptide Y (NPY) is a 36-amino-acid neurotransmitter which is widely distributed throughout the central and peripheral nervous system. NPY involvement has…”
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Angiotensin II Receptor Blockade: Is There Truly a Benefit of Adding an ACE Inhibitor? by Forclaz, Andrei, Maillard, Marc, Nussberger, Jürg, Brunner, Hans R, Burnier, Michel

“…ABSTRACT—We assessed the blockade of the renin-angiotensin system (RAS) achieved with 2 angiotensin (Ang) antagonists given either alone at different doses or…”
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Influence of Oscillatory and Unidirectional Flow Environments on the Expression of Endothelin and Nitric Oxide Synthase in Cultured Endothelial Cells by Ziegler, Thierry, Bouzourene, Karima, Harrison, Vanessa J, Brunner, Hans R, Hayoz, Daniel

“…In vivo, endothelial cells (ECs) are subjected to a complex mechanical environment composed of shear stress, pressure, and circumferential stretch. The aim of…”
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Monitoring compliance in resistant hypertension: an important step in patient management by Burnier, Michel, Santschi, Valérie, Favrat, Bernard, Brunner, Hans R

“…Poor compliance with antihypertensive drug regimens is one recognized cause of inadequate blood pressure control. Compliance is difficult to measure, so poor…”
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Experimental and clinical evidence that angiotensin II is an independent risk factor for cardiovascular disease by Brunner, Hans R

“…The role of the renin–angiotensin system in the regulation of normal blood pressure and in the pathogenesis of hypertension has long been appreciated…”
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The new oral angiotensin II antagonist olmesartan medoxomil: a concise overview by BRUNNER, H. R

“…The new orally active angiotensin II (A II) type-1 receptor antagonist olmesartan medoxomil is a prodrug, which is rapidly converted in vivo to the active…”
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Determination of cardiac contractility in awake unsedated mice with a fluid-filled catheter by Wang, Qing, Brunner, Hans R, Burnier, Michel

“…Today, cardiac contractility in mice is exclusively measured under anesthesia or in sedated animals because the catheters available are too rigid to be used in…”
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Clinical efficacy and tolerability of olmesartan by Brunner, Hans R

“…Background: Olmesartan medoxomil is an angiotensin II receptor antagonist that selectively and competitively inhibits the angiotensin 11 type 1 receptor…”
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Increased Cardiac Angiotensin II Levels Induce Right and Left Ventricular Hypertrophy in Normotensive Mice by Mazzolai, Lucia, Pedrazzini, Thierry, Nicoud, Françoise, Gabbiani, Giulio, Brunner, Hans-R, Nussberger, Jürg

“…Angiotensin II is a potent arterial vasoconstrictor and induces hypertension. Angiotensin II also exerts a trophic effect on cardiomyocytes in vitro. The goals…”
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Angiotensin blockade for hypertension: a promise fulfilled by Brunner, Hans R, Gavras, Haralambos

“…To normalise blood pressure, more than one drug is generally needed. The LIFE trial design can therefore be considered close to the way antihypertensive…”
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