Search Results - "Brunn, Sandra A."

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O, Parkhill, Eric Q, Vasilevich, Natalya I, Glushkov, Andrei I, Zilbershtein, Timur M, Ivanov, Alexei V, Cole, Andrew G, Henderson, Ian, Zautke, Nathan A, Brunn, Sandra A, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W, Zablocki, Jeff

“…We identified a series of structurally novel SCD (Delta9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the…”
Get full text

Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Zilbershtein, Timur M., Migulin, Vasily A., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., McGregor, Malcolm J., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…Two structurally distinct series of SCD (Δ9 desaturase) inhibitors (1 and 2) have been previously reported by our group. In the present work, we merged the…”
Get full text

Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., Zilbershtein, Timur M., Mayboroda, Elena I., Boze, Melanie A., Cole, Andrew G., Henderson, Ian, Zautke, Nathan A., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…We discovered a structurally novel SCD inhibitor CVT-11,563 (IC50 119nM, HEPG2 assay), selective against Δ5 and Δ6 desaturases, with excellent PK parameters…”
Get full text

Auxin transport and the interaction of phytotropins. Probing the properties of a phytotropin binding protein by BRUNN, S. A, MUDAY, G. K, HAWORTH, P

“…We have described the inhibition of polar auxin transport by several phytotropins including 1-N-naphthylphthalamic acid (NPA) and quercetin. Semicarbazones…”
Get full text

Evidence for a single naphthylphthalamic acid binding site on the zucchini plasma membrane by Muday, G.K, Brunn, S.A, Haworth, P, Subramanian, M

“…The binding of [2,3,4,5,(n)-3H]N-1-napthylphthalamic acid ([3H]-NPA) to zucchini (Cucurbita pepo L.) plasma membranes was examined in detail using two…”
Get full text

Revisiting auxin transport inhibition as a mode of action for herbicides by Subramanian, Mani V., Brunn, Sandra A., Bernasconi, Paul, Patel, Bhavesh C., Reagan, Jeff D.

“…SCB-1, a semicarbazone, is a phytotoxin with both preemergence and postemergence activity against broadleaves and grasses. It effectively displaced…”
Get full text

Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, ZILBERSHTEIN, Timur M, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, MIGULIN, Vasily A, VASILEVICH, Natalya I, PARKHILL, Eric Q, GLUSHKOV, Andrei I, MCGREGOR, Malcolm J, BRUNN, Sandra A, CHU, Nancy, JIA HAO

Get full text

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, PARKHILL, Eric Q, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, VASILEVICH, Natalya I, GLUSHKOV, Andrei I, ZILBERSHTEIN, Timur M, IVANOV, Alexei V, COLE, Andrew G, HENDERSON, Ian, ZAUTKE, Nathan A, BRUNN, Sandra A

Get full text

Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, VASILEVICH, Natalya I, BRUNN, Sandra A, CHU, Nancy, JIA HAO, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, PARKHILL, Eric Q, GLUSHKOV, Andrei I, ZILBERSHTEIN, Timur M, MAYBORODA, Elena I, BOZE, Melanie A, COLE, Andrew G, HENDERSON, Ian, ZAUTKE, Nathan A

Get full text

Cysteine residues at the active site of glutamine synthetase from spinach leaves by Ericson, M C, Brunn, S A

“…Titration of cysteine residues of spinach glutamine synthetase with 5-5' dithiobis (2-nitrobenzoic acid) indicates that there are five such residues per…”
Get more information