Search Results - "Brunetto, André T."

EHMT2/G9a as an Epigenetic Target in Pediatric and Adult Brain Tumors by Souza, Barbara Kunzler, Freire, Natalia Hogetop, Jaeger, Mariane, de Farias, Caroline Brunetto, Brunetto, Algemir L, Brunetto, André T, Roesler, Rafael

“…Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during…”
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Possible mechanisms and biomarkers of resistance to vismodegib in SHH medulloblastoma by Roesler, Rafael, de Farias, Caroline Brunetto, Brunetto, André T, Gregianin, Lauro, Jaeger, Mariane, Nör, Carolina, Thomaz, Amanda

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Cancer Stem Cells and Chemoresistance in Ewing Sarcoma by Dos Santos, Rafael Pereira, Roesler, Rafael, Gregianin, Lauro, Brunetto, André T, da Cunha Jaeger, Mariane, Lunardi Brunetto, Algemir, de Farias, Caroline Brunetto

“…Resistance to chemotherapy poses a major challenge for cancer treatment. Reactivating a stem cell program resembling that seen in embryonic development can…”
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Incidence and risk factors for oral mucositis in pediatric patients receiving chemotherapy by Curra, Marina, Gabriel, Amanda F., Ferreira, Maria Beatriz C., Martins, Marco Antonio T., Brunetto, André T., Gregianin, Lauro J., Martins, Manoela Domingues

“…Purpose To investigate the incidence and risk factors for oral mucositis (OM) in patients with childhood cancer undergoing chemotherapy. Methods Eight hundred…”
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Oncogenic functions of ZEB1 in pediatric solid cancers: interplays with microRNAs and long noncoding RNAs by Fratini, Lívia, Jaeger, Mariane, de Farias, Caroline Brunetto, Brunetto, André T., Brunetto, Algemir L., Shaw, Lisa, Roesler, Rafael

“…The transcription factor Zinc finger E-box binding 1 (ZEB1) displays a range of regulatory activities in cell function and embryonic development, including…”
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Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma by Souza, Barbara Kunzler, Freire, Natalia Hogetop, Monteiro, Thiago Santos, Herlinger, Alice Laschuk, Jaeger, Mariane, Dalmolin, Matheus G. S., de Farias, Caroline Brunetto, Gregianin, Lauro, Brunetto, André T., Brunetto, Algemir L., Thiele, Carol J., Roesler, Rafael

“…Changes in epigenetic programming have been proposed as being key events in the initiation and progression of childhood cancers. HMT euchromatic histone lysine…”
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Neurotrophin Signaling in Medulloblastoma by Thomaz, Amanda, Jaeger, Mariane, Brunetto, Algemir L, Brunetto, André T, Gregianin, Lauro, de Farias, Caroline Brunetto, Ramaswamy, Vijay, Nör, Carolina, Taylor, Michael D, Roesler, Rafael

“…Neurotrophins are a family of secreted proteins that act by binding to tropomyosin receptor kinase (Trk) or p75NTR receptors to regulate nervous system…”
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G9a/EHMT2 is a Potential Prognostic Biomarker and Molecular Target in SHH Medulloblastoma by Souza, Barbara Kunzler, Freire, Natalia Hogetop, Jaeger, Mariane, de Farias, Caroline Brunetto, Brunetto, Algemir L., Brunetto, André T., Roesler, Rafael

“…Changes in epigenetic programming are associated with cancer development during childhood. Components of the epigenetic machinery involved in normal embryonic…”
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ZEB1 is a Subgroup-Specific Marker of Prognosis and Potential Drug Target in Medulloblastoma by Fratini, Livia, Dalmolin, Matheus Gibeke Siqueira, Sinigaglia, Marialva, da Silveira Perla, Alexandre, de Farias, Caroline Brunetto, Brunetto, Algemir L., Brunetto, André T., da Cunha Jaeger, Mariane, Roesler, Rafael

“…Medulloblastoma (MB) is a malignant brain tumor that afflicts mostly children and adolescents and presents four distinct molecular subgroups, known as WNT,…”
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Stemness and Cell Cycle Regulators and Their Modulation by Retinoic Acid in Ewing Sarcoma by Battistella, Maria Eduarda, Freire, Natália Hogetop, Toson, Bruno, Dalmolin, Matheus, Fernandes, Marcelo A C, Tassinari, Isadora D, Jaeger, Mariane, Brunetto, André T, Brunetto, Algemir L, Gregianin, Lauro, de Farias, Caroline Brunetto, Roesler, Rafael

“…Retinoic acid (RA) regulates stemness and differentiation in human embryonic stem cells (ESCs). Ewing sarcoma (ES) is a pediatric tumor that may arise from the…”
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HDAC and MAPK/ERK Inhibitors Cooperate To Reduce Viability and Stemness in Medulloblastoma by da Cunha Jaeger, Mariane, Ghisleni, Eduarda Chiesa, Cardoso, Paula Schoproni, Siniglaglia, Marialva, Falcon, Tiago, Brunetto, André T., Brunetto, Algemir L., de Farias, Caroline Brunetto, Taylor, Michael D., Nör, Carolina, Ramaswamy, Vijay, Roesler, Rafael

“…Medulloblastoma (MB), which originates from embryonic neural stem cells (NSCs) or neural precursors in the developing cerebellum, is the most common malignant…”
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Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential by Perla, Alexandre, Fratini, Lívia, Cardoso, Paula S., Nör, Carolina, Brunetto, André T., Brunetto, Algemir L., de Farias, Caroline Brunetto, Jaeger, Mariane, Roesler, Rafael

“…Brain cancers are the leading cause of cancer-related deaths in children. Biological changes in these tumors likely include epigenetic deregulation during…”
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Targeting Histone Deacetylase Activity to Arrest Cell Growth and Promote Neural Differentiation in Ewing Sarcoma by Souza, Bárbara Kunzler, da Costa Lopez, Patrícia Luciana, Menegotto, Pâmela Rossi, Vieira, Igor Araujo, Kersting, Nathalia, Abujamra, Ana Lúcia, Brunetto, André T., Brunetto, Algemir L., Gregianin, Lauro, de Farias, Caroline Brunetto, Thiele, Carol J., Roesler, Rafael

“…There is an urgent need for advances in the treatment of Ewing sarcoma (EWS), an aggressive childhood tumor with possible neuroectodermal origin. Inhibition of…”
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First-in-human, Pharmacokinetic and Pharmacodynamic Phase I Study of Resminostat, an Oral Histone Deacetylase Inhibitor, in Patients with Advanced Solid Tumors by BRUNETTO, André T, JOO ERN ANG, HAUNS, Bernhard, STROBEL, Vera, HENTSCH, Bernd, DE BONO, Johann S, LAI, Rohit, OLMOS, David, MOLIFE, L. Rhoda, KRISTELEIT, Rebecca, PARKER, Ann, CASAMAYOR, Isabel, OLALEYE, Muyibat, MAIS, Anna

“…This first-in-human dose-escalating trial investigated the safety, tolerability, maximum tolerated dose (MTD), dose-limiting toxicities (DLT),…”
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Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma by Thomaz, Amanda, Pinheiro, Kelly de Vargas, Souza, Bárbara Kunzler, Gregianin, Lauro, Brunetto, Algemir L, Brunetto, André T, de Farias, Caroline Brunetto, Jaeger, Mariane da Cunha, Ramaswamy, Vijay, Nör, Carolina, Taylor, Michael D, Roesler, Rafael

“…Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that…”
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BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells by Thomaz, Amanda, Jaeger, Mariane, Buendia, Marienela, Bambini-Junior, Victorio, Gregianin, Lauro José, Brunetto, Algemir Lunardi, Brunetto, André T., de Farias, Caroline Brunetto, Roesler, Rafael

“…Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Deregulation of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B…”
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Viability of D283 medulloblastoma cells treated with a histone deacetylase inhibitor combined with bombesin receptor antagonists by Jaeger, Mariane, Ghisleni, Eduarda C., Fratini, Lívia, Brunetto, Algemir L., Gregianin, Lauro José, Brunetto, André T., Schwartsmann, Gilberto, de Farias, Caroline B., Roesler, Rafael

“…Purpose Medulloblastoma (MB) comprises four distinct molecular subgroups, and survival remains particularly poor in patients with Group 3 tumors. Mutations and…”
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Phase I Trial of a Selective c-MET Inhibitor ARQ 197 Incorporating Proof of Mechanism Pharmacodynamic Studies by YAP, Timothy A, OLMOS, David, COLLINS, David, DESOUZA, Nandita M, LEACH, Martin O, SAVAGE, Ronald E, WAGHORNE, Carol, FENG CHAI, GARMEY, Edward, SCHWARTZ, Brian, KAYE, Stan B, DE BONO, Johann S, BRUNETTO, Andre T, TUNARIU, Nina, BARRIUSO, Jorge, RIISNAES, Ruth, POPE, Lorna, CLARK, Jeremy, FUTREAL, Andrew, GERMUSKA, Michael

“…The hepatocyte growth factor/c-MET axis is implicated in tumor cell proliferation, survival, and angiogenesis. ARQ 197 is an oral, selective, non-adenosine…”
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Patient Selection for Oncology Phase I Trials: A Multi-Institutional Study of Prognostic Factors by OLMOS, David, A'HERN, Roger P, SCHELLENS, Jan H, DEL CONTE, Gianluca, BRUNETTO, Andre T, JEFFRY EVANS, T. R, WILSON, Richard, GALLERANI, Elisa, PLUMMER, Ruth, TABERNERO, Josep, SORIA, Jean-Charles, KAYE, Stan B, MARSONI, Silvia, MORALES, Rafael, GOMEZ-ROCA, Carlos, VERWEIJ, Jaap, VOEST, Emile E, SCHÖFFSKI, Patrick, JOO ERN ANG, PENEL, Nicolas

“…The appropriate selection of patients for early clinical trials presents a major challenge. Previous analyses focusing on this problem were limited by small…”
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Dose-response relationship in phase i clinical trials: a European Drug Development Network (EDDN) Collaboration Study by Moreno García, Victor, Olmos, David, Gomez-Roca, Carlos, Cassier, Philippe A, Morales-Barrera, Rafael, Del Conte, Gianluca, Gallerani, Elisa, Brunetto, Andre T, Schöffski, Patrick, Marsoni, Silvia, Schellens, Jan H M, Penel, Nicolas, Voest, Emile, Evans, Jeffrey, Plummer, Ruth, Wilson, Richard H, Soria, Jean Charles, Tabernero, Josep, Verweij, Jaap, Kaye, Stan B

“…Because a dose-response relationship is characteristic of conventional chemotherapy, this concept is widely used for the development of novel cytotoxic (CTX)…”
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