Search Results - "Brunel, Luc"

Ghrelin knockout mice show decreased voluntary alcohol consumption and reduced ethanol-induced conditioned place preference by Bahi, Amine, Tolle, Virginie, Fehrentz, Jean-Alain, Brunel, Luc, Martinez, Jean, Tomasetto, Catherine-Laure, Karam, Sherif M.

“…► Ghrelin KO displayed lower ethanol-CPP. ► Ghrelin receptor antagonist JMV2959 reduced CPP-expression in C57BL/6 mice. ► Ghrelin KO displayed lower…”
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Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins by Lambey, Paul, Otun, Omolade, Cong, Xiaojing, Hoh, François, Brunel, Luc, Verdié, Pascal, Grison, Claire M, Peysson, Fanny, Jeannot, Sylvain, Durroux, Thierry, Bechara, Cherine, Granier, Sébastien, Leyrat, Cédric

“…(SA) leukocidin ED (LukED) belongs to a family of bicomponent pore forming toxins that play important roles in SA immune evasion and nutrient acquisition…”
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A Collagen-Mimetic Organic-Inorganic Hydrogel for Cartilage Engineering by Valot, Laurine, Maumus, Marie, Brunel, Luc, Martinez, Jean, Amblard, Muriel, Noël, Danièle, Mehdi, Ahmad, Subra, Gilles

“…Promising strategies for cartilage regeneration rely on the encapsulation of mesenchymal stromal cells (MSCs) in a hydrogel followed by an injection into the…”
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Involvement of PPARγ in the Anticonvulsant Activity of EP-80317, a Ghrelin Receptor Antagonist by Lucchi, Chiara, Costa, Anna M, Giordano, Carmela, Curia, Giulia, Piat, Marika, Leo, Giuseppina, Vinet, Jonathan, Brunel, Luc, Fehrentz, Jean-Alain, Martinez, Jean, Torsello, Antonio, Biagini, Giuseppe

“…Ghrelin, des-acyl ghrelin and other related peptides possess anticonvulsant activities. Although ghrelin and cognate peptides were shown to physiologically…”
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The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist by Moulin, Aline, Brunel, Luc, Boeglin, Damien, Demange, Luc, Ryan, Johanne, M’Kadmi, Céline, Denoyelle, Séverine, Martinez, Jean, Fehrentz, Jean-Alain

“…Ghrelin is a 28-residue peptide acylated with an n -octanoyl group on the Ser 3 residue, predominantly produced by the stomach. Ghrelin displays strong growth…”
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Progressive Seizure Aggravation in the Repeated 6-Hz Corneal Stimulation Model Is Accompanied by Marked Increase in Hippocampal p-ERK1/2 Immunoreactivity in Neurons by Giordano, Carmela, Costa, Anna M, Lucchi, Chiara, Leo, Giuseppina, Brunel, Luc, Fehrentz, Jean-Alain, Martinez, Jean, Torsello, Antonio, Biagini, Giuseppe

“…The 6-Hz corneal stimulation test is used to screen novel antiepileptic molecules to overcome the problem of drug refractoriness. Although recognized as a…”
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Pharmacologic antagonism of ghrelin receptors attenuates development of nicotine induced locomotor sensitization in rats by Wellman, Paul J., Clifford, P. Shane, Rodriguez, Juan, Hughes, Samuel, Eitan, Shoshana, Brunel, Luc, Fehrentz, Jean-Alain, Martinez, Jean

“…Ghrelin (GHR) is an orexigenic gut peptide that interacts with ghrelin receptors (GHR-Rs) to modulate brain reinforcement circuits. Systemic GHR infusions…”
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Synthesis of Peptide Alcohols on the Basis of an O-N Acyl-Transfer Reaction by Tailhades, Julien, Gidel, Marie-Aude, Grossi, Benjamin, Lécaillon, Jennifer, Brunel, Luc, Subra, Gilles, Martinez, Jean, Amblard, Muriel

“…Getting the better of troublemakers: C‐terminal peptide alcohols cannot be synthesized by conventional solid‐phase peptide synthesis (SPPS) because of the…”
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Sol–gel synthesis of collagen-inspired peptide hydrogel by Echalier, Cécile, Jebors, Said, Laconde, Guillaume, Brunel, Luc, Verdié, Pascal, Causse, Léa, Bethry, Audrey, Legrand, Baptiste, Van Den Berghe, Hélène, Garric, Xavier, Noël, Danièle, Martinez, Jean, Mehdi, Ahmad, Subra, Gilles

“…Conceiving biomaterials able to mimic the specific environments of extracellular matrices are a prerequisite for tissue engineering applications. Numerous…”
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In vitro and in vivo application of radiolabeled gastrin-releasing peptide receptor ligands in breast cancer by Dalm, Simone U, Martens, John W M, Sieuwerts, Anieta M, van Deurzen, Carolien H M, Koelewijn, Stuart J, de Blois, Erik, Maina, Theodosia, Nock, Berthold A, Brunel, Luc, Fehrentz, Jean-Alain, Martinez, Jean, de Jong, Marion, Melis, Marleen

“…Breast cancer (BC) consists of multiple subtypes defined by various molecular characteristics, for instance, estrogen receptor (ER) expression. Methods for…”
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Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors by Clifford, P. Shane, Rodriguez, Juan, Schul, Destri, Hughes, Samuel, Kniffin, Tracey, Hart, Nigel, Eitan, Shoshana, Brunel, Luc, Fehrentz, Jean-Alain, Martinez, Jean, Wellman, Paul J.

“…ABSTRACT Systemic infusions of the orexigenic peptide ghrelin (GHR) increase dopamine levels within the nucleus accumbens and augment cocaine‐stimulated…”
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In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies by Chatalic, Kristell L S, Konijnenberg, Mark, Nonnekens, Julie, de Blois, Erik, Hoeben, Sander, de Ridder, Corrina, Brunel, Luc, Fehrentz, Jean-Alain, Martinez, Jean, van Gent, Dik C, Nock, Berthold A, Maina, Theodosia, van Weerden, Wytske M, de Jong, Marion

“…A single tool for early detection, accurate staging, and personalized treatment of prostate cancer (PCa) would be a major breakthrough in the field of PCa…”
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Gastrin Releasing Peptide Receptor-Directed Radioligands Based on a Bombesin Antagonist: Synthesis, 111 In-Labeling, and Preclinical Profile by Marsouvanidis, Panteleimon J., Nock, Berthold A., Hajjaj, Bouchra, Fehrentz, Jean-Alain, Brunel, Luc, M’Kadmi, Céline, van der Graaf, Linda, Krenning, Eric P., Maina, Theodosia, Martinez, Jean, de Jong, Marion

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Gastrin releasing peptide receptor-directed radioligands based on a bombesin antagonist: synthesis, (111)in-labeling, and preclinical profile by Marsouvanidis, Panteleimon J, Nock, Berthold A, Hajjaj, Bouchra, Fehrentz, Jean-Alain, Brunel, Luc, M'Kadmi, Céline, van der Graaf, Linda, Krenning, Eric P, Maina, Theodosia, Martinez, Jean, de Jong, Marion

“…Novel bombesin (BBN) antagonists were synthesized by coupling the chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to…”
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Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule by Kelly, Lois M, Rutter, Justine C, Lin, Kevin H, Ling, Frank, Duchmann, Matthieu, Latour, Emmanuelle, Arang, Nadia, Pasquer, Hélène, Ho Nhat, Duong, Charles, Juliette, Killarney, Shane T, Ang, Hazel X, Namor, Federica, Culeux, Cécile, Lombard, Bérangère, Loew, Damarys, Swaney, Danielle L, Krogan, Nevan J, Brunel, Luc, Carretero, Élodie, Verdié, Pascal, Amblard, Muriel, Fodil, Sofiane, Huynh, Tony, Sebert, Marie, Adès, Lionel, Raffoux, Emmanuel, Fenouille, Nina, Itzykson, Raphaël, Lobry, Camille, Benajiba, Lina, Forget, Antoine, Martin, Anthony R, Wood, Kris C, Puissant, Alexandre

“…Dose-limiting toxicity poses a major limitation to the clinical utility of targeted cancer therapies, often arising from target engagement in nonmalignant…”
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Preclinical Comparison of Al^sup 18^F- and ^sup 68^Ga-Labeled Gastrin-Releasing Peptide Receptor Antagonists for PET Imaging of Prostate Cancer by Chatalic, Kristell LS, Franssen, Gerben M, van Weerden, Wytske M, McBride, William J, Laverman, Peter, de Blois, Erik, Hajjaj, Bouchra, Brunel, Luc, Goldenberg, David M, Fehrentz, Jean-Alain, Martinez, Jean, Boerman, Otto C, de Jong, Marion

“…Gastrin-releasing peptide receptor (GRPR) is overexpressed in human prostate cancer and is being used as a target for molecular imaging. In this study, we…”
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Preclinical Comparison of Al 18 F- and 68 Ga-Labeled Gastrin-Releasing Peptide Receptor Antagonists for PET Imaging of Prostate Cancer by Chatalic, Kristell L.S., Franssen, Gerben M., van Weerden, Wytske M., McBride, William J., Laverman, Peter, de Blois, Erik, Hajjaj, Bouchra, Brunel, Luc, Goldenberg, David M., Fehrentz, Jean-Alain, Martinez, Jean, Boerman, Otto C., de Jong, Marion

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Preclinical Comparison of Al super(18)F- and super(68)Ga-Labeled Gastrin-Releasing Peptide Receptor Antagonists for PET Imaging of Prostate Cancer by Chatalic, Kristell LS, Franssen, Gerben M, van Weerden, Wytske M, McBride, William J, Laverman, Peter, de Blois, Erik, Hajjaj, Bouchra, Brunel, Luc, Goldenberg, David M, Fehrentz, Jean-Alain, Martinez, Jean, Boerman, Otto C, de Jong, Marion

“…Gastrin-releasing peptide receptor (GRPR) is overexpressed in human prostate cancer and is being used as a target for molecular imaging. In this study, we…”
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An innovative strategy for sulfopeptides analysis using MALDI-TOF MS reflectron positive ion mode by Cantel, Sonia, Brunel, Luc, Ohara, Keiichiro, Enjalbal, Christine, Martinez, Jean, Vasseur, Jean-Jacques, Smietana, Michael

“…Sulfation of tyrosine residues is a key posttranslational modification in the regulation of various cellular processes. As such, the detection and localization…”
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Preclinical comparison of Al18F- and 68Ga-labeled gastrin-releasing peptide receptor antagonists for PET imaging of prostate cancer by Chatalic, Kristell L S, Franssen, Gerben M, van Weerden, Wytske M, McBride, William J, Laverman, Peter, de Blois, Erik, Hajjaj, Bouchra, Brunel, Luc, Goldenberg, David M, Fehrentz, Jean-Alain, Martinez, Jean, Boerman, Otto C, de Jong, Marion

“…Gastrin-releasing peptide receptor (GRPR) is overexpressed in human prostate cancer and is being used as a target for molecular imaging. In this study, we…”
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