Search Results - "Brune, Kieran"

Pulmonary epithelial barrier function: some new players and mechanisms by Brune, Kieran, Frank, James, Schwingshackl, Andreas, Finigan, James, Sidhaye, Venkataramana K

“…The pulmonary epithelium serves as a barrier to prevent access of the inspired luminal contents to the subepithelium. In addition, the epithelium dictates the…”
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HIV Impairs Lung Epithelial Integrity and Enters the Epithelium to Promote Chronic Lung Inflammation by Brune, Kieran A, Ferreira, Fernanda, Mandke, Pooja, Chau, Eric, Aggarwal, Neil R, D'Alessio, Franco R, Lambert, Allison A, Kirk, Gregory, Blankson, Joel, Drummond, M Bradley, Tsibris, Athe M, Sidhaye, Venkataramana K

“…Several clinical studies show that individuals with HIV are at an increased risk for worsened lung function and for the development of COPD, although the…”
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Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension by Nishida, Kristine, Brune, Kieran A, Putcha, Nirupama, Mandke, Pooja, O'Neal, Wanda K, Shade, Danny, Srivastava, Vasudha, Wang, Menghan, Lam, Hong, An, Steven S, Drummond, M Bradley, Hansel, Nadia N, Robinson, Douglas N, Sidhaye, Venkataramana K

“…Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Cigarette smoke (CS) drives disease development and progression. The…”
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PancPRO: Risk Assessment for Individuals With a Family History of Pancreatic Cancer by Wang, Wenyi, Chen, Sining, Brune, Kieran A, Hruban, Ralph H, Parmigiani, Giovanni, Klein, Alison P

“…The rapid fatality of pancreatic cancer is, in large part, the result of an advanced stage of diagnosis for the majority of patients. Identification of…”
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Importance of Age of Onset in Pancreatic Cancer Kindreds by Brune, Kieran A., Lau, Bryan, Palmisano, Emily, Canto, Marcia, Goggins, Michael G., Hruban, Ralph H., Klein, Alison P.

“…Background Young-onset cancer is a hallmark of many familial cancer syndromes, yet the implications of young-onset disease in predicting risk of pancreatic…”
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Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds by KLEIN, Alison P, BRUNE, Kieran A, HRUBAN, Ralph H, PETERSEN, Gloria M, GOGGINS, Michael, TERSMETTE, Anne C, OFFERHAUS, G. Johan A, GRIFFIN, Constance, CAMERON, John L, YEA, Charles J, KERN, Scott

“…Individuals with a family history of pancreatic cancer have an increased risk of developing pancreatic cancer. Quantification of this risk provides a rational…”
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Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study by Canto, Marcia Irene, Goggins, Michael, Hruban, Ralph H, Petersen, Gloria M, Giardiello, Francis M, Yeo, Charles, Fishman, Elliott K, Brune, Kieran, Axilbund, Jennifer, Griffin, Constance, Ali, Syed, Richman, Jeffrey, Jagannath, Sanjay, Kantsevoy, Sergey V, Kalloo, Anthony N

“…Individuals with a strong family history of pancreatic cancer and persons with Peutz-Jeghers syndrome (PJS) have an increased risk for pancreatic cancer. This…”
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The Prevalence of BRCA2 Mutations in Familial Pancreatic Cancer by COUCH, Fergus J, JOHNSON, Michele R, HRUBAN, Ralph H, RABE, Kari G, BRUNE, Kieran, DE ANDRADE, Mariza, GOGGINS, Michael, ROTHENMUND, Heidi, GALLINGER, Steven, KLEIN, Alison, PETERSEN, Gloria M

“…Mutations in the BRCA2 gene have been implicated in pancreatic cancer susceptibility through studies of high-risk breast and ovarian cancer families. To…”
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Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach by Canto, Marcia Irene, Goggins, Michael, Yeo, Charles J, Griffin, Constance, Axilbund, Jennifer E, Brune, Kieran, Ali, Syed Z, Jagannath, Sanjay, Petersen, Gloria M, Fishman, Elliot K, Piantadosi, Steven, Giardiello, Francis M, Hruban, Ralph H

“…Relatives of patients with pancreatic cancer and persons with certain inherited syndromes are at increased risk for developing pancreatic cancer. We…”
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Elevated Cancer Mortality in the Relatives of Patients with Pancreatic Cancer by LI WANG, BRUNE, Kieran A, KLEIN, Alison P, VISVANATHAN, Kala, LAHERU, Daniel, HERMAN, Joseph, WOLFGANG, Christoper, SCHULICK, Richard, CAMERON, John L, GOGGINS, Michael, HRUBAN, Ralph H

“…Most inherited cancer syndromes are characterized by the familial clustering of cancers at several organ sites. To determine if cancers, other than pancreatic…”
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Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: Deleterious BRCA2 mutations in 17 by MURPHY, Kathleen M, BRUNE, Kieran A, GRIFFIN, Constance, SOLLENBERGER, Jennifer E, PETERSEN, Gloria M, BANSAL, Ravi, HRUBAN, Ralph H, KERN, Scott E

“…It is estimated that familial aggregation and genetic susceptibility play a role in as many as 10% of pancreatic ductal adenocarcinomas. To investigate the…”
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Genetic and Epigenetic Alterations of Familial Pancreatic Cancers by Brune, Kieran, Hong, Seung-Mo, Li, Ang, Yachida, Shinichi, Abe, Tadayoshi, Griffith, Margaret, Yang, Dawei, Omura, Noriyuki, Eshleman, James, Canto, Marcia, Schulick, Rich, Klein, Alison P, Hruban, Ralph H, Iacobuzio-Donohue, Christine, Goggins, Michael

“…Background: Little is known about the genetic and epigenetic changes that contribute to familial pancreatic cancers. The aim of this study was to compare the…”
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Absence of germline BRCA1 mutations in familial pancreatic cancer patients by Axilbund, Jennifer E, Argani, Pedram, Kamiyama, Mihoko, Palmisano, Emily, Raben, Marian, Borges, Michael, Brune, Kieran A, Goggins, Michael, Hruban, Ralph H, Klein, Alison P

“…Recent studies have suggested that germ line mutations in the BRCA1 gene may confer an increased risk of developing pancreatic cancer. To determine if BRCA1…”
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Genome-Wide Allelotypes of Familial Pancreatic Adenocarcinomas and Familial and Sporadic Intraductal Papillary Mucinous Neoplasms by ABE, Tadayoshi, FUKUSHIMA, Noriyoshi, BRUNE, Kieran, BOEHM, Corinne, SATO, Norihiro, MATSUBAYASHI, Hiroyuki, CANTO, Marcia, PETERSEN, Gloria M, HRUBAN, Ralph H, GOGGINS, Michael

“…Purpose: Most familial cancer susceptibility genes are tumor suppressor genes that are biallelically inactivated in familial neoplasms through somatic deletion…”
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Methylation of Cyclin D2 Is Observed Frequently in Pancreatic Cancer but Is Also an Age-related Phenomenon in Gastrointestinal Tissues by MATSUBAYASHI, Hiroyuki, SATO, Norihiro, FUKUSHIMA, Noriyoshi, YEO, Charles J, WALTER, Kimberly M, BRUNE, Kieran, SAHIN, Fikret, HRUBAN, Ralph H, GOGGINS, Michael

“…Purpose : Hypermethylation of CpG islands in the promoters of selected genes is a common feature of neoplasia. Aberrantmethylation of cyclin D2 has been…”
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Absence of Deleterious Palladin Mutations in Patients with Familial Pancreatic Cancer by KLEIN, Alison P, BORGES, Michael, GRIFFITH, Margaret, BRUNE, Kieran, HONG, Seung-Mo, OMURA, Noriyuki, HRUBAN, Ralph H, GOGGINS, Michael

“…It has been reported that germline mutations in the palladin gene ( PALLD ) cause the familial aggregation of pancreatic cancer, but the evidence is weak and…”
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Increased prevalence of the BRCA2 polymorphic stop codon K3326X among individuals with familial pancreatic cancer by MARTIN, Sean T, MATSUBAYASHI, Hiroyuki, ROGERS, Carmelle D, PHILIPS, Juliet, COUCH, Fergus J, BRUNE, Kieran, YEO, Charles J, KERN, Scott E, HRUBAN, Ralph H, GOGGINS, Michael

“…Germline BRCA2 mutations predispose to the development of pancreatic cancer. A polymorphic stop codon in the coding region of BRCA2 (K3326X) has been…”
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Clinical importance of precursor lesions in the pancreas by Hruban, Ralph H., Takaori, Kyoichi, Canto, Marcia, Fishman, Elliot K., Campbell, Kurtis, Brune, Kieran, Kern, Scott E., Goggins, Michael

“…Three distinct noninvasive precursor lesions to invasive ductal adenocarcinoma of the pancreas have been described. These include the mucinous cystic neoplasm,…”
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Evidence for a major gene influencing risk of pancreatic cancer by Klein, Alison P., Beaty, Terri H., Bailey-Wilson, Joan E., Brune, Kieran A., Hruban, Ralph H., Petersen, Gloria M.

“…Family history of pancreatic cancer, the fifth leading cause of cancer death in the United States, confers a 1.5–13‐fold higher risk of developing pancreatic…”
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Copy-number variants in patients with a strong family history of pancreatic cancer by Lucito, Robert, Suresh, Shubha, Walter, Kimberly, Pandey, Akhilesh, Lakshmi, B., Krasnitz, Alex, Sebat, Jonathan, Wigler, Michael, Klein, Alison P., Brune, Kieran, Palmisano, Emily, Maitra, Anirban, Goggins, Michael, Hruban, Ralph H.

“…Copy-number variants such as germ-line deletions and amplifications are associated with inherited genetic disorders including familial cancer. The gene or…”
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