Search Results - "Brundin, Patrik"

Is COVID-19 a Perfect Storm for Parkinson’s Disease? by Brundin, Patrik, Nath, Avindra, Beckham, J. David

“…Three recent case reports (by Méndez-Guerrero et al.,Cohen et al., and Faber et al.) describe the development of acute parkinsonism following coronavirus…”
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Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder? by Olanow, C. Warren, Brundin, Patrik

“…ABSTRACT Altered protein handling is thought to play a key role in the etiopathogenesis of Parkinson's disease (PD), as the disorder is characterized…”
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Prion-like transmission of protein aggregates in neurodegenerative diseases by Brundin, Patrik, Melki, Ronald, Kopito, Ron

“…Neurodegenerative diseases are associated with the accumulation of intracellular or extracellular protein aggregates that form because of protein misfolding…”
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Parkinson Disease Epidemiology, Pathology, Genetics and Pathophysiology by Simon, David K., MD PhD, Tanner, Caroline M., MD, PhD, Brundin, Patrik, MD, PhD

“…Parkinson’s disease (PD) is a complex age-related neurodegenerative disease associated with dopamine deficiency and both motor and nonmotor deficits. Many…”
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Therapeutic approaches to target alpha-synuclein pathology by Brundin, Patrik, Dave, Kuldip D., Kordower, Jeffrey H.

“…Starting two decades ago with the discoveries of genetic links between alpha-synuclein and Parkinson's disease risk and the identification of aggregated…”
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The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases by Rey, Nolwen L, Wesson, Daniel W, Brundin, Patrik

“…Abstract Olfactory deficits are present in numerous neurodegenerative disorders and are accompanied by pathology in related brain regions. In several of these…”
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Cancer enzyme affects Parkinson's disease by Brundin, Patrik, Wyse, Richard

“…New insights identify a possible target for slowing neurodegeneration Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by…”
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Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation by Mezias, Christopher, Rey, Nolwen, Brundin, Patrik, Raj, Ashish

“…In Parkinson's disease, some of the first alpha-synuclein aggregates appear in the olfactory system and the dorsal motor nucleus of the vagus nerve before…”
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Sorting out release, uptake and processing of alpha‐synuclein during prion‐like spread of pathology by Tyson, Trevor, Steiner, Jennifer A., Brundin, Patrik

“…Parkinson's disease is a progressive neurological disorder that is characterized by the formation of intracellular protein inclusion bodies composed primarily…”
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The vermiform appendix impacts the risk of developing Parkinson's disease by Killinger, Bryan A, Madaj, Zachary, Sikora, Jacek W, Rey, Nolwen, Haas, Alec J, Vepa, Yamini, Lindqvist, Daniel, Chen, Honglei, Thomas, Paul M, Brundin, Patrik, Brundin, Lena, Labrie, Viviane

“…The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated α-synuclein, which has been suggested to begin in the gastrointestinal…”
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Gut feelings about smoking and coffee in Parkinson's disease by Derkinderen, Pascal, Shannon, Kathleen M, Brundin, Patrik

“…ABSTRACT Strong epidemiologic evidence suggests that smokers and coffee drinkers have a lower risk of Parkinson's disease (PD). The explanation for this…”
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Impact of the COVID‐19 Pandemic on Parkinson's Disease and Movement Disorders by Papa, Stella M., Brundin, Patrik, Fung, Victor S.C., Kang, Un Jung, Burn, David J., Colosimo, Carlo, Chiang, Han‐Lin, Alcalay, Roy N., Trenkwalder, Claudia

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Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain by Li, Wen, Englund, Elisabet, Widner, Ha°kan, Mattsson, Bengt, van Westen, Danielle, Lätt, Jimmy, Rehncrona, Stig, Brundin, Patrik, Björklund, Anders, Lindvall, Olle, Li, Jia-Yi

“…Clinical trials using cells derived from embryonic ventral mesencephalon have shown that transplanted dopaminergic neurons can survive and function in the long…”
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Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection by Labrie, Viviane, Brundin, Patrik

“…Intraneuronal accumulation of misfolded alpha-synuclein in the central and peripheral nervous systems is strongly linked to Parkinson disease (PD) and other…”
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Alpha-synuclein transfers from neurons to oligodendrocytes by Reyes, Juan F., Rey, Nolwen L., Bousset, Luc, Melki, Ronald, Brundin, Patrik, Angot, Elodie

“…The origin of α‐synuclein (α‐syn)‐positive glial cytoplasmic inclusions found in oligodendrocytes in multiple system atrophy (MSA) is enigmatic, given the fact…”
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Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease by Kasen, Alysa, Houck, Christina, Burmeister, Amanda R., Sha, Qiong, Brundin, Lena, Brundin, Patrik

“…Alpha-synuclein (α-syn) has been suggested to have many functions including, vesicle transport in neurons, transcriptional regulator, modulator of immune cell…”
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Can infections trigger alpha-synucleinopathies? by Tulisiak, Christopher T, Mercado, Gabriela, Peelaerts, Wouter, Brundin, Lena, Brundin, Patrik

“…As synucleinopathies, Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that involve the spread of pathogenic…”
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Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases by Espay, Alberto J, Vizcarra, Joaquin A, Marsili, Luca, Lang, Anthony E, Simon, David K, Merola, Aristide, Josephs, Keith A, Fasano, Alfonso, Morgante, Francesca, Savica, Rodolfo, Greenamyre, J Timothy, Cambi, Franca, Yamasaki, Tritia R, Tanner, Caroline M, Gan-Or, Ziv, Litvan, Irene, Mata, Ignacio F, Zabetian, Cyrus P, Brundin, Patrik, Fernandez, Hubert H, Standaert, David G, Kauffman, Marcelo A, Schwarzschild, Michael A, Sardi, S Pablo, Sherer, Todd, Perry, George, Leverenz, James B

“…The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer…”
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Deficits in olfactory sensitivity in a mouse model of Parkinson’s disease revealed by plethysmography of odor-evoked sniffing by Johnson, Michaela E., Bergkvist, Liza, Mercado, Gabriela, Stetzik, Lucas, Meyerdirk, Lindsay, Wolfrum, Emily, Madaj, Zachary, Brundin, Patrik, Wesson, Daniel W.

“…Hyposmia is evident in over 90% of Parkinson’s disease (PD) patients. A characteristic of PD is intraneuronal deposits composed in part of α-synuclein fibrils…”
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Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson's disease by George, Sonia, Rey, Nolwen L, Tyson, Trevor, Esquibel, Corinne, Meyerdirk, Lindsay, Schulz, Emily, Pierce, Steven, Burmeister, Amanda R, Madaj, Zachary, Steiner, Jennifer A, Escobar Galvis, Martha L, Brundin, Lena, Brundin, Patrik

“…Cell-to-cell propagation of α-synuclein (α-syn) aggregates is thought to contribute to the pathogenesis of Parkinson's disease (PD) and underlie the spread of…”
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