Search Results - "Brundel, Bianca J.J.M."

Role of Small-Conductance Calcium-Activated Potassium Channels in Atrial Electrophysiology and Fibrillation in the Dog by Qi, Xiao-Yan, Diness, Jonas G, Brundel, Bianca J.J.M, Zhou, Xiao-Bo, Naud, Patrice, Wu, Chia-Tung, Huang, Hai, Harada, Masahide, Aflaki, Mona, Dobrev, Dobromir, Grunnet, Morten, Nattel, Stanley

“…BACKGROUND—Recent evidence points to functional Ca-dependent K (SK) channels in the heart that may govern atrial fibrillation (AF) risk, but the underlying…”
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Cellular Signaling Underlying Atrial Tachycardia Remodeling of L-type Calcium Current by Qi, Xiao Yan, Yeh, Yung-Hsin, Xiao, Ling, Burstein, Brett, Maguy, Ange, Chartier, Denis, Villeneuve, Louis R, Brundel, Bianca J.J.M, Dobrev, Dobromir, Nattel, Stanley

“…Atrial tachycardia (AT) downregulates L-type Ca current (ICaL) and causes atrial fibrillation–promoting electric remodeling. This study assessed potential…”
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Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation by Zhang, Deli, Ke, Lei, Mackovicova, Katarina, Der Want, Johannes J.L. Van, Sibon, Ody C.M, Tanguay, Robert M, Morrow, Genevieve, Henning, Robert H, Kampinga, Harm H, Brundel, Bianca J.J.M

“…Abstract The most common clinical tachycardia, Atrial Fibrillation (AF), is a progressive disease, caused by cardiomyocyte remodeling, which finally results in…”
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The Calcium/Calmodulin/Kinase System and Arrhythmogenic Afterdepolarizations in Bradycardia-Related Acquired Long-QT Syndrome by Qi, Xiao Yan, Yeh, Yung-Hsin, Chartier, Denis, Xiao, Ling, Tsuji, Yukiomi, Brundel, Bianca J.J.M, Kodama, Itsuo, Nattel, Stanley

“…BACKGROUND—Sustained bradycardia is associated with long-QT syndrome in human beings and causes spontaneous torsades de pointes in rabbits with chronic…”
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Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation by Zhang, Deli, Hu, Xu, Henning, Robert H, Brundel, Bianca J J M

“…Cardiomyocytes are long-lived post-mitotic cells with limited regenerative capacity. Proper cardiomyocyte function depends critically on the maintenance of a…”
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Blood-based 8-hydroxy-2′-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation by Li, Jin, Zhang, Deli, Ramos, Kennedy S., Baks, Luciënne, Wiersma, Marit, Lanters, Eva A.H., Bogers, Ad J.J.C., de Groot, Natasja M.S., Brundel, Bianca J.J.M.

“…Recent research findings have revealed a key role of oxidative DNA damage in the pathogenesis of atrial fibrillation (AF). Therefore, the circulating oxidative…”
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Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation by Wiersma, Marit, van Marion, Denise M S, Wüst, Rob C I, Houtkooper, Riekelt H, Zhang, Deli, Groot, Natasja M S de, Henning, Robert H, Brundel, Bianca J J M

“…Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs electrical activation of the atria,…”
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The protective role of small heat shock proteins in cardiac diseases: key role in atrial fibrillation by Hu, Xu, Van Marion, Denise M. S., Wiersma, Mark, Zhang, Deli, Brundel, Bianca J. J. M.

“…Atrial fibrillation (AF) is the most common tachyarrhythmia which is associated with increased morbidity and mortality. AF usually progresses from a…”
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Derailed Proteostasis as a Determinant of Cardiac Aging by Wiersma, Marit, PhD, Henning, Robert H., MD, PhD, Brundel, Bianca J.J.M., PhD

“…Abstract Age comprises the single most important risk factor for cardiac disease development. The incidence and prevalence of cardiac diseases, which…”
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Cell-Free Circulating Mitochondrial DNA: A Potential Blood-Based Marker for Atrial Fibrillation by Wiersma, Marit, van Marion, Denise M S, Bouman, Emma J, Li, Jin, Zhang, Deli, Ramos, Kennedy S, Lanters, Eva A H, de Groot, Natasja M S, Brundel, Bianca J J M

“…Atrial fibrillation (AF), the most common, progressive tachyarrhythmia is associated with serious complications, such as stroke and heart failure. Early…”
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The Role of Proteostasis Derailment in Cardiac Diseases by Brundel, Bianca J J M

“…The incidence and prevalence of cardiac diseases, which are the main cause of death worldwide, are likely to increase because of population ageing and changes…”
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Induction of Heat Shock Response Protects the Heart Against Atrial Fibrillation by Brundel, Bianca J.J.M, Shiroshita-Takeshita, Akiko, Qi, XiaoYan, Yeh, Yung-Hsin, Chartier, Denis, van Gelder, Isabelle C, Henning, Robert H, Kampinga, Harm H, Nattel, Stanley

“…There is evidence suggesting that heat shock proteins (HSPs) may protect against clinical atrial fibrillation (AF). We evaluated the effect of HSP induction in…”
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Atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (AFFIP): Rationale and design by Starreveld, Roeliene, Knops, Paul, Ramos, Kennedy S., Roos‐Serote, Maarten C., Bogers, Ad J.J.C., Brundel, Bianca J.J.M., Groot, Natasja M.S.

“…Background The exact pathophysiology of atrial fibrillation (AF) remains incompletely understood and treatment of AF is associated with high recurrence rates…”
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Mechanisms of Atrial Fibrillation: Lessons From Animal Models by Nattel, Stanley, Shiroshita-Takeshita, Akiko, Brundel, Bianca J.J.M., Rivard, Léna

“…Studies in animal models have provided extremely important insights about atrial fibrillation (AF). The classic mechanisms that still form the framework for…”
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Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation by van Marion, Denise Ms, Hu, Xu, Zhang, Deli, Hoogstra-Berends, Femke, Seerden, Jean-Paul G, Loen, Lizette, Heeres, Andre, Steen, Herman, Henning, Robert H, Brundel, Bianca Jjm

“…The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental…”
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Reviving the protein quality control system: Therapeutic target for cardiac disease in the elderly by Meijering, Roelien A.M., PhD, Henning, Robert H., Prof, Brundel, Bianca J.J.M., PhD

“…Abstract It has been firmly established that ageing constitutes a principal risk factor for cardiac disease. Currently, the underlying mechanisms of ageing…”
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Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation by Ke, Lei, Qi, Xiao Yan, Dijkhuis, Anne-Jan, Chartier, Denis, Nattel, Stanley, Henning, Robert H, Kampinga, Harm H, Brundel, Bianca J.J.M

“…Abstract The self-perpetuation of atrial fibrillation (AF) is associated with atrial remodeling, including the degradation of the myofibril structure…”
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Evaluating Serum Heat Shock Protein Levels as Novel Biomarkers for Atrial Fibrillation by Marion, Denise M S van, Lanters, Eva A H, Ramos, Kennedy S, Li, Jin, Wiersma, Marit, Baks-Te Bulte, Luciënne, J Q M Muskens, Agnes, Boersma, Eric, de Groot, Natasja M S, Brundel, Bianca J J M

“…Staging of atrial fibrillation (AF) is essential to understanding disease progression and the accompanied increase in therapy failure. Blood-based heat shock…”
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Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation by Brundel, Bianca J.J.M., Henning, Robert H., Ke, Lei, van Gelder, Isabelle C., Crijns, Harry J.G.M., Kampinga, Harm H.

“…Atrial fibrillation (AF) causes myocyte stress by inducing structural changes, predominantly myolysis, which is related to the progression of AF. As heat shock…”
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Heat Shock Protein–Inducing Compounds as Therapeutics to Restore Proteostasis in Atrial Fibrillation by Hoogstra-Berends, Femke, Meijering, Roelien A.M, Zhang, Deli, Heeres, André, Loen, Lizette, Seerden, Jean-Paul, Kuipers, Irma, Kampinga, Harm H, Henning, Robert H, Brundel, Bianca J.J.M

“…Atrial fibrillation (AF) is the most common clinical tachyarrhythmia associated with significant morbidity and mortality and is expected to affect…”
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