Search Results - "Brunazzi, Erin"

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ by Liu, Chang, Chikina, Maria, Deshpande, Rahul, Menk, Ashley V., Wang, Ting, Tabib, Tracy, Brunazzi, Erin A., Vignali, Kate M., Sun, Ming, Stolz, Donna B., Lafyatis, Robert A., Chen, Wei, Delgoffe, Greg M., Workman, Creg J., Wendell, Stacy G., Vignali, Dario A.A.

“…Regulatory T (Treg) cells are crucial for immune homeostasis, but they also contribute to tumor immune evasion by promoting a suppressive tumor…”
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Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity by Overacre-Delgoffe, Abigail E., Chikina, Maria, Dadey, Rebekah E., Yano, Hiroshi, Brunazzi, Erin A., Shayan, Gulidanna, Horne, William, Moskovitz, Jessica M., Kolls, Jay K., Sander, Cindy, Shuai, Yongli, Normolle, Daniel P., Kirkwood, John M., Ferris, Robert L., Delgoffe, Greg M., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A.A.

“…Regulatory T cells (Tregs) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is required to maintain intratumoral Treg stability and function but is…”
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Interferon-γ Drives T reg Fragility to Promote Anti-tumor Immunity by Overacre-Delgoffe, Abigail E, Chikina, Maria, Dadey, Rebekah E, Yano, Hiroshi, Brunazzi, Erin A, Shayan, Gulidanna, Horne, William, Moskovitz, Jessica M, Kolls, Jay K, Sander, Cindy, Shuai, Yongli, Normolle, Daniel P, Kirkwood, John M, Ferris, Robert L, Delgoffe, Greg M, Bruno, Tullia C, Workman, Creg J, Vignali, Dario A A

“…Regulatory T cells (T ) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is required to maintain intratumoral T stability and function but is…”
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Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3 by Grebinoski, Stephanie, Zhang, Qianxia, Cillo, Anthony R., Manne, Sasikanth, Xiao, Hanxi, Brunazzi, Erin A., Tabib, Tracy, Cardello, Carly, Lian, Christine G., Murphy, George F., Lafyatis, Robert, Wherry, E. John, Das, Jishnu, Workman, Creg J., Vignali, Dario A. A.

“…Impaired chronic viral and tumor clearance has been attributed to CD8 + T cell exhaustion, a differentiation state in which T cells have reduced and altered…”
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Regulatory T Cell Insufficiency in Autoimmune Diabetes Is Driven by Selective Loss of Neuropilin-1 on Intraislet Regulatory T Cells by Grebinoski, Stephanie, Pieklo, Gwenyth, Zhang, Qianxia, Visperas, Anabelle, Cui, Jian, Goulet, Jordana, Xiao, Hanxi, Brunazzi, Erin A, Cardello, Carly, Herrada, Andrés A, Das, Jishnu, Workman, Creg J, Vignali, Dario A A

“…Approaches to reverse or limit regulatory T cell (Treg) insufficiency are of great interest for development of immunotherapeutic treatments for autoimmune…”
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LAG-3 and PD-1 synergize on CD8 + T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity by Andrews, Lawrence P, Butler, Samuel C, Cui, Jian, Cillo, Anthony R, Cardello, Carly, Liu, Chang, Brunazzi, Erin A, Baessler, Andrew, Xie, Bingxian, Kunning, Sheryl R, Ngiow, Shin Foong, Huang, Yinghui Jane, Manne, Sasikanth, Sharpe, Arlene H, Delgoffe, Greg M, Wherry, E John, Kirkwood, John M, Bruno, Tulia C, Workman, Creg J, Vignali, Dario A A

“…Overcoming immune-mediated resistance to PD-1 blockade remains a major clinical challenge. Enhanced efficacy has been demonstrated in melanoma patients with…”
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A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells by Andrews, Lawrence P., Vignali, Kate M., Szymczak-Workman, Andrea L., Burton, Amanda R., Brunazzi, Erin A., Ngiow, Shin Foong, Harusato, Akihito, Sharpe, Arlene H., Wherry, E. John, Taniuchi, Ichiro, Workman, Creg J., Vignali, Dario A.A.

“…CD4+ T cells share common developmental pathways with CD8+ T cells, and upon maturation, CD4+ T conventional T (Tconv) cells lack phenotypic markers that…”
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Regulatory T Cell-Derived TRAIL Is Not Required for Peripheral Tolerance by Dadey, Rebekah E, Grebinoski, Stephanie, Zhang, Qianxia, Brunazzi, Erin A, Burton, Amanda, Workman, Creg J, Vignali, Dario A A

“…TRAIL ( /TRAIL/CD253/Apo2L) is an important immune molecule that mediates apoptosis. TRAIL can play key roles in regulating cell death in the tumor and…”
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Ebi3 Binding to IFN-γ and IL-10 Limits Their Function by Scott, Ellen N, Ye, Cheng, Yano, Hiroshi, Lipatova, Zhanna, Brunazzi, Erin, Vignali, Kate M, Workman, Creg J, Vignali, Dario A A

“…EBV-induced gene 3 (Ebi3) is a β subunit within the IL-12 cytokine family that canonically binds to α subunits p19, p28, or p35 to form the heterodimeric…”
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Treg-restricted deletion of TRAIL (Tnfsf10) reduces autoimmune diabetes by Dadey, Rebekah, Grebinoski, Stephanie J, Zhang, Qianxia, Gocher, Angela, Brunazzi, Erin, Andrews, Lawrence Peter, Burton, Amanda, Workman, Creg, Vignali, Dario

“…Regulatory T cells (Tregs) are a suppressive cell population that limit the anti-tumor response. One mechanism Tregs utilize is production of suppressive…”
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31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one by Zhang, Xiaonan, Lorent, Julie, Uemura, Marc, Tawbi, Hussein, Woodman, Scott, Bernatchez, Chantale, Logan, Theodore, Gu, Xuemin, Khushalani, Nikhil, Toth, Kyle, Carpentier, Sabrina, Galon, Jérôme, Haydu, Lauren E, Kline, Douglas, Workman, Creg, Ansa-Addo, Ephraim A, Maroto, Miguel, Chagin, Karen, Mackall, Crystal, Bennett, Alan D, Felber, Barbara, Assadipour, Yasmine, Gokuldass, Aishwarya, Hammill, Joanne, Bramson, Jonathan, Yu, Zhiya, Soon-Shiong, Patrick, Ruella, Marco, Hegde, Meenakshi, Hovgaard, Dorrit, Nguyen, Sang, Xue, Allen, Veerapathran, Anandaraman, Gunset, Gertrude, Angell, Helen K, Hodgson, Darren R, Ayers, Mark, Levitan, Diane, Liu, Fang, Yung-Jue Bang, Schalper, Kurt, Topalian, Suzanne, Conlon, Kevin, Delcommenne, Marc, Chin-Fu, Hsiao, Backert, Linus, Howells-Ferreira, Ana, Siraj, Ali, White, Eileen, Sun, Yongming, Glenn, Sean, Ehrmann, Jon M, Korman, Alan J, Reuben, Alex, Amin, Asim, Steingrimsson, Arni, Tufman, Amanda, Berger, Frank, Handy, John, Tian, Zhigang, Kulkarni, Anupriya, Edward El Rassi, Clayburgh, Daniel R, Hagberg, Hans, Zimarino, Carlo, De Bono, Johann, Özcan Met, Grossenbacher, Steven, Richards, Jon, Le, Dung T, Lee, Jean K, Leighl, Natasha, Copeland, Larry, Nam, Kijoeng, Pegram, Mark D, Juhler-Nøttrup, Trine, Tran, Ben, Qin, Zhen, Khattri, Arun, Shah, Jatin, Matsumoto, Morio, Yimer, Habte, MacKinnon, Andy, Whiting, Sam, Sondel, Paul M, Heery, Christopher R, Esteller, Manel, Park, Johanna, Leland, Pamela, Hastings, William D, Dranoff, Glenn, Bose, Nandita, Crocker, Andrea, Hartnett, Jim, Cong, Mei, Rachida-Siham Bel Aiba, Spranger, Stefani, Shukla, Sachet A, Boussiotis, Vassiliki A, Moran, Amy E

“…Adoptive Cellular TherapyO1 IL-15 primes an mTOR-regulated gene-expression program to prolong anti-tumor capacity of human natural killer cellsAndreas…”
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