Search Results - "Brumwell, Alexis N."

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration by Xi, Ying, Kim, Thomas, Brumwell, Alexis N., Driver, Ian H., Wei, Ying, Tan, Victor, Jackson, Julia R., Xu, Jianming, Lee, Dong-Kee, Gotts, Jeffrey E., Matthay, Michael A., Shannon, John M., Chapman, Harold A., Vaughan, Andrew E.

“…After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a…”
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Alveolar Epithelial Cell Mesenchymal Transition Develops in vivo during Pulmonary Fibrosis and Is Regulated by the Extracellular Matrix by Kim, Kevin K., Kugler, Matthias C., Wolters, Paul J., Robillard, Liliane, Galvez, Michael G., Brumwell, Alexis N., Sheppard, Dean, Chapman, Harold A.

“…Mechanisms leading to fibroblast accumulation during pulmonary fibrogenesis remain unclear. Although there is in vitro evidence of lung alveolar…”
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Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline by Xi, Ying, Tan, Kevin, Brumwell, Alexis N, Chen, Steven C, Kim, Yong-Hyun, Kim, Thomas J, Wei, Ying, Chapman, Harold A

“…A high-throughput small-molecule screen was conducted to identify inhibitors of epithelial-mesenchymal transition (EMT) that could be used as tool compounds to…”
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Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration by Kathiriya, Jaymin J., Brumwell, Alexis N., Jackson, Julia R., Tang, Xiaodan, Chapman, Harold A.

“…Lung injury activates specialized adult epithelial progenitors to regenerate the epithelium. Depending on the extent of injury, both remaining alveolar type II…”
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Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis by Wiley, Christopher D., Brumwell, Alexis N., Davis, Sonnet S., Jackson, Julia R., Valdovinos, Alexis, Calhoun, Cheresa, Alimirah, Fatouma, Castellanos, Carlos A., Ruan, Richard, Wei, Ying, Chapman, Harold A., Ramanathan, Arvind, Campisi, Judith, Jourdan Le Saux, Claude

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Human distal airways contain a multipotent secretory cell that can regenerate alveoli by Basil, Maria C., Cardenas-Diaz, Fabian L., Kathiriya, Jaymin J., Morley, Michael P., Carl, Justine, Brumwell, Alexis N., Katzen, Jeremy, Slovik, Katherine J., Babu, Apoorva, Zhou, Su, Kremp, Madison M., McCauley, Katherine B., Li, Shanru, Planer, Joseph D., Hussain, Shah S., Liu, Xiaoming, Windmueller, Rebecca, Ying, Yun, Stewart, Kathleen M., Oyster, Michelle, Christie, Jason D., Diamond, Joshua M., Engelhardt, John F., Cantu, Edward, Rowe, Steven M., Kotton, Darrell N., Chapman, Harold A., Morrisey, Edward E.

“…The human lung differs substantially from its mouse counterpart, resulting in a distinct distal airway architecture affected by disease pathology in chronic…”
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Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype by Wang, Chaoqun, de Mochel, Nabora S Reyes, Christenson, Stephanie A, Cassandras, Monica, Moon, Rebecca, Brumwell, Alexis N, Byrnes, Lauren E, Li, Alfred, Yokosaki, Yasuyuki, Shan, Peiying, Sneddon, Julie B, Jablons, David, Lee, Patty J, Matthay, Michael A, Chapman, Harold A, Peng, Tien

“…GWAS have repeatedly mapped susceptibility loci for emphysema to genes that modify hedgehog signaling, but the functional relevance of hedgehog signaling to…”
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Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis by Kim, Kevin K, Wei, Ying, Szekeres, Charles, Kugler, Matthias C, Wolters, Paul J, Hill, Marla L, Frank, James A, Brumwell, Alexis N, Wheeler, Sarah E, Kreidberg, Jordan A, Chapman, Harold A

“…Pulmonary fibrosis, in particular idiopathic pulmonary fibrosis (IPF), results from aberrant wound healing and scarification. One population of fibroblasts…”
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A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis by Cohen, Max L, Brumwell, Alexis N, Ho, Tsung Che, Garakani, Kiana, Montas, Genevieve, Leong, Darren, Ding, Vivianne W, Golden, Jeffrey A, Trinh, Binh N, Jablons, David M, Matthay, Michael A, Jones, Kirk D, Wolters, Paul J, Wei, Ying, Chapman, Harold A, Le Saux, Claude Jourdan

“…Reciprocal interactions between alveolar fibroblasts and epithelial cells are crucial for lung homeostasis, injury repair, and fibrogenesis, but underlying…”
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Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis by Wiley, Christopher D, Brumwell, Alexis N, Davis, Sonnet S, Jackson, Julia R, Valdovinos, Alexis, Calhoun, Cheresa, Alimirah, Fatouma, Castellanos, Carlos A, Ruan, Richard, Wei, Ying, Chapman, Harold A, Ramanathan, Arvind, Campisi, Judith, Jourdan Le Saux, Claude

“…Accumulation of senescent cells is associated with the progression of pulmonary fibrosis, but mechanisms accounting for this linkage are not well understood…”
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Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury by Vaughan, Andrew E., Brumwell, Alexis N., Xi, Ying, Gotts, Jeffrey E., Brownfield, Doug G., Treutlein, Barbara, Tan, Kevin, Tan, Victor, Liu, Feng Chun, Looney, Mark R., Matthay, Michael A., Rock, Jason R., Chapman, Harold A.

“…Lineage-tracing experiments identify a rare, undifferentiated population of quiescent cells in the mouse distal lung that are activated through a Notch…”
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Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with β1 integrins by Tang, Chi-Hui, Hill, Marla L, Brumwell, Alexis N, Chapman, Harold A, Wei, Ying

“…The urokinase receptor (uPAR) is upregulated upon tumor cell invasion and correlates with poor lung cancer survival. Although a cis-interaction with integrins…”
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Integrin α3β1-Dependent β-Catenin Phosphorylation Links Epithelial Smad Signaling to Cell Contacts by Kim, Young, Kugler, Matthias C., Wei, Ying, Kim, Kevin K., Li, Xiaopeng, Brumwell, Alexis N., Chapman, Harold A.

“…Injury-initiated epithelial to mesenchymal transition (EMT) depends on contextual signals from the extracellular matrix, suggesting a role for integrin…”
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A fibroblast-dependent TGF-[beta]1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis by Cohen, Max L, Brumwell, Alexis N, Ho, Tsung Che, Garakani, Kiana, Montas, Genevieve, Leong, Darren, Ding, Vivianne W, Golden, Jeffrey A, Trinh, Binh N, Jablons, David M, Matthay, Michael A, Jones, Kirk D, Wolters, Paul J, Wei, Ying, Chapman, Harold A, Le Saux, Claude Jourdan

“…Reciprocal interactions between alveolar fibroblasts and epithelial cells are crucial for lung homeostasis, injury repair, and fibrogenesis, but underlying…”
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Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia by Xi, Y, Wei, Y, Sennino, B, Ulsamer, A, Kwan, I, Brumwell, A N, Tan, K, Aghi, M K, McDonald, D M, Jablons, D M, Chapman, H A

“…Hypoxia is linked to epithelial–mesenchymal transition (EMT) and tumor progression in numerous carcinomas. Responses to hypoxia are thought to operate via…”
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Lineage-negative progenitorsmobilize to regenerate lung epithelium after major injury by Vaughan, Andrew E, Brumwell, Alexis N, Xi, Ying, Gotts, Jeffrey E, Brownfield, Doug G, Treutlein, Barbara, Tan, Kevin, Tan, Victor, Liu, Feng Chun, Looney, Mark R, Matthay, Michael A, Rock, Jason R, Chapman, Harold A

“…Broadly, tissue regeneration is achieved in two ways: by proliferation of common differentiated cells and/or by deployment of specialized stem/progenitor…”
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Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins by Tang, Chi-Hui, Hill, Marla L, Brumwell, Alexis N, Chapman, Harold A, Wei, Ying

“…The urokinase receptor (uPAR) is upregulated upon tumor cell invasion and correlates with poor lung cancer survival. Although a cis-interaction with integrins…”
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Integrin [alpha]3[beta]1-dependent [beta]-catenin phosphorylation links epithelial Smad signaling to cell contacts by Kim, Young, Kugler, Matthias C, Wei, Ying, Kim, Kevin K, Li, Xiaopeng, Brumwell, Alexis N, Chapman, Harold A

“…Injury-initiated epithelial to mesenchymal transition (EMT) depends on contextual signals from the extracellular matrix, suggesting a role for integrin…”
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Epithelial cell [alpha]3[beta]1 integrin links [beta]-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis by Kim, Kevin K, Wei, Ying, Szekeres, Charles, Kugler, Matthias C, Wolters, Paul J, Hill, Maria L, Frank, James A, Brumwell, Alexis N, Wheeler, Sarah E, Kreidberg, Jordan A, Chapman, Harold A

“…Pulmonary fibrosis, in particular idiopathic pulmonary fibrosis (IPF), results from aberrant wound healing and scarification. One population of fibroblasts…”
Get full text

Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis by Kim, Kevin K, Wei, Ying, Szekeres, Charles, Kugler, Matthias C, Wolters, Paul J, Hill, Marla L, Frank, James A, Brumwell, Alexis N, Wheeler, Sarah E, Kreidberg, Jordan A, Chapman, Harold A

“…Pulmonary fibrosis, in particular idiopathic pulmonary fibrosis (IPF), results from aberrant wound healing and scarification. One population of fibroblasts…”
Get full text