Search Results - "Brummett, Robert E."

Delayed Sodium Thiosulfate as an Otoprotectant Against Carboplatin-induced Hearing Loss in Patients with Malignant Brain Tumors by DOOLITTLE, Nancy D, MULDOON, Leslie L, BRUMMETT, Robert E, TYSON, Rose Marie, LACY, Cynthia, BUBALO, Joseph S, KRAEMER, Dale F, HEINRICH, Michael C, HENRY, James A, NEUWELT, Edward A

“…Carboplatin is effective in the treatment of malignant brain tumors. However, when administered in conjunction with osmotic opening of the blood-brain barrier…”
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Delayed Administration of Sodium Thiosulfate in Animal Models Reduces Platinum Ototoxicity without Reduction of Antitumor Activity by MULDOON, L. L, PAGEL, M. A, KROLL, R. A, BRUMMETT, R. E, DOOLITTLE, N. D, ZUHOWSKI, E. G, EGORIN, M. J, NEUWELT, E. A

“…Platinum-based chemotherapeutic agents, such as carboplatin and cisplatin, are effective against many human tumors, but their use may be limited by a high…”
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First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate by Neuwelt, E A, Brummett, R E, Doolittle, N D, Muldoon, L L, Kroll, R A, Pagel, M A, Dojan, R, Church, V, Remsen, L G, Bubalo, J S

“…Sodium thiosulfate (STS) provides protection against carboplatin-induced ototoxicity in an animal model. The purpose of this study was to determine the STS…”
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In vitro and animal studies of sodium thiosulfate as a potential chemoprotectant against carboplatin-induced ototoxicity by Neuwelt, E A, Brummett, R E, Remsen, L G, Kroll, R A, Pagel, M A, McCormick, C I, Guitjens, S, Muldoon, L L

“…When carboplatin (cis-diammine-1,1-cyclobutane-dicarboxylato-platinum) delivery to brain tumors is optimized with osmotic blood-brain barrier disruption…”
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Effects of Antibiotic-Diuretic Interactions in the Guinea Pig Model of Ototoxicity by Brummett, R E

“…The guinea pig model has been useful for estimating quantitatively the ototoxic effects of many different drugs. Our model utilizes measures of the Preyer…”
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Warning to otolaryngologists using local anesthetics containing epinephrine. Potential serious reaction occurring in patients treated with beta-adrenergic receptor blockers by Brummett, R E

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Toxicity and Efficacy of Carboplatin and Etoposide in Conjunction with Disruption of the Blood-Brain Tumor Barrier in the Treatment of Intracranial Neoplasms by Williams, Paul C., Henner, W. David, Simon, Roman-Goldstein, Dahlborg, Suellen A., Brummett, Robert E., Tableman, Mara, Dana, Bruce W., Neuwelt, Edward A.

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The incidence of aminoglycoside antibiotic-induced hearing loss by Brummett, R E, Morrison, R B

“…The definition of ototoxicity in most clinical studies of aminoglycoside antibiotics is an increase in pure-tone threshold from a baseline audiogram greater…”
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A system for evaluating auditory function from 8000--20 000 Hz by Fausti, S A, Frey, R H, Erickson, D A, Rappaport, B Z, Cleary, E J, Brummett, R E

“…A system for the measurement of auditory function from 8000--20 000 Hz is described. This system introduces advances in: (a) maximum power output, (b) signal…”
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Steroids and rhinoplasty. A double-blind study by Hoffmann, D F, Cook, T A, Quatela, V C, Wang, T D, Brownrigg, P J, Brummett, R E

“…Many facial plastic surgeons use perioperative steroids to reduce postoperative edema and morbidity. This use of steroids is based more on theory and anecdotal…”
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Quantitative relationships of the interaction between sound and kanamycin by Brummett, R E, Fox, K E, Kempton, J B

“…It is well known that the ototoxicity resulting from the use of aminoglycoside antibiotics in experimental animals can be augmented by intense sound. However,…”
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Augmented gentamicin ototoxicity induced by vancomycin in guinea pigs by Brummett, R E, Fox, K E, Jacobs, F, Kempton, J B, Stokes, Z, Richmond, A B

“…Vancomycin has been reported to be an ototoxic drug in the clinical literature. At best, this literature is confusing. There are no reports of ototoxicity of…”
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Interaction of kanamycin and ethacrynic acid. Severe cochlear damage in guinea pigs by West, B A, Brummett, R E, Himes, D L

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Effects of pentoxifylline on experimental skin flap survival by Hodgson, R S, Brummett, R E, Cook, T A

“…We studied the effects of pentoxifylline on experimental skin flap survival in the domestic pig. Random skin flaps were designed using a length-width ratio of…”
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A comparative study of the ototoxicity of tobramycin and gentamicin by Brummett, R E, Himes, D, Saine, B, Vernon, J

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Treatment of recurrent laryngeal nerve injury by Doyle, P J, Everts, E C, Brummett, R E

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Combined effects of noise and kanamycin. Cochlear pathology and pharmacology by Brown, J J, Brummett, R E, Fox, K E, Bendrick, T W

“…Concurrent administration of aminoglycoside antibiotics and acoustic exposure is reported to result in a cochlear damage level exceeding that predicted from…”
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Lidocaine in the treatment of tinnitus aurium. A double-blind study by Israel, J M, Connelly, J S, McTigue, S T, Brummett, R E, Brown, J

“…Available reports suggest that lidocaine is capable of relieving symptoms of tinnitus, but no convincing data support this conclusion. By use of a…”
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Comparative ototoxic liability of netilmicin and gentamicin by Brummett, R E, Fox, K E, Brown, R T, Himes, D L

“…Netilmicin sulfate is a new aminoglycoside antibiotic currently undergoing clinical investigation. All of the aminoglycoside antibiotics now in clinical use…”
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Quantitative relationships of the ototoxic interaction of kanamycin and ethacrynic acid by Brummett, R E, Brown, R T, Himes, D L

“…We determined the range of doses of kanamycin sulfate and ethacrynic acid that results in an ototoxic interaction in guinea pigs. In addition, we determined…”
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