Search Results - "Brummendorf, T H"

Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML by Schütz, C, Inselmann, S, Sausslele, S, Dietz, C T, Müller, M C, Eigendorff, E, Brendel, C A, Metzelder, S K, Brümmendorf, T H, Waller, C, Dengler, J, Goebeler, M E, Herbst, R, Freunek, G, Hanzel, S, Illmer, T, Wang, Y, Lange, T, Finkernagel, F, Hehlmann, R, Huber, M, Neubauer, A, Hochhaus, A, Guilhot, J, Xavier Mahon, F, Pfirrmann, M, Burchert, A

“…It is unknown, why only a minority of chronic myeloid leukemia (CML) patients sustains treatment free remission (TFR) after discontinuation of tyrosine kinase…”
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Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifies RIPK4 as novel tumor suppressor in human hepatocarcinogenesis by Heim, D, Cornils, K, Schulze, K, Fehse, B, Lohse, A W, Brümmendorf, T H, Wege, H

“…Carcinogenesis is a multistep process involving alterations in various cellular pathways. The critical genetic events driving the evolution of primary liver…”
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Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling by Andersson, E I, Pützer, S, Yadav, B, Dufva, O, Khan, S, He, L, Sellner, L, Schrader, A, Crispatzu, G, Oleś, M, Zhang, H, Adnan-Awad, S, Lagström, S, Bellanger, D, Mpindi, J P, Eldfors, S, Pemovska, T, Pietarinen, P, Lauhio, A, Tomska, K, Cuesta-Mateos, C, Faber, E, Koschmieder, S, Brümmendorf, T H, Kytölä, S, Savolainen, E-R, Siitonen, T, Ellonen, P, Kallioniemi, O, Wennerberg, K, Ding, W, Stern, M-H, Huber, W, Anders, S, Tang, J, Aittokallio, T, Zenz, T, Herling, M, Mustjoki, S

“…T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its…”
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Rare FLT3 deletion mutants may provide additional treatment options to patients with AML: an approach to individualized medicine by Chatain, N, Perera, R C, Rossetti, G, Rossa, J, Carloni, P, Schemionek, M, Haferlach, T, Brümmendorf, T H, Schnittger, S, Koschmieder, S

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Phase I II trial of cilengitide with cetuximab, cisplatin and 5-fluorouracil in recurrent and or metastatic squamous cell cancer of the head and neck: findings of the phase I part by Vermorken, J B, Guigay, J, Mesia, R, Trigo, J M, Keilholz, U, Kerber, A, Bethe, U, Picard, M, Brummendorf, T H

“…Background: Novel therapies are needed to improve the poor prognosis of patients with recurrent and/or metastatic squamous cell cancer of the head and neck…”
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Consequences of Telomerase Inhibition by BIBR1532 on Proliferation and Chemosensitivity of Chondrosarcoma Cell Lines by Parsch, D., Brassat, U., Brümmendorf, T. H., Fellenberg, J.

“…Purpose: Human chondrosarcomas are generally resistant to conventional treatments like chemotherapy and radiotherapy. We investigated the effects of BIBR1532,…”
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Telomere length in leukocyte subpopulations of patients with aplastic anemia by BRÜMMENDORF, Tim H, MACIEJEWSKI, Jaroslaw P, MAK, Jennifer, YOUNG, Neal S, LANSDORP, Peter M

“…In most human cells, the average length of telomere repeats at the ends of chromosomes provides indirect information about their mitotic history. To study the…”
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Bleeding, thrombosis, and anticoagulation in myeloproliferative neoplasms (MPN): analysis from the German SAL-MPN-registry by Kaifie, A, Kirschner, M, Wolf, D, Maintz, C, Hänel, M, Gattermann, N, Gökkurt, E, Platzbecker, U, Hollburg, W, Göthert, J R, Parmentier, S, Lang, F, Hansen, R, Isfort, S, Schmitt, K, Jost, E, Serve, H, Ehninger, G, Berdel, W E, Brümmendorf, T H, Koschmieder, S

“…Patients with Ph-negative myeloproliferative neoplasms (MPN), such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF),…”
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Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry by Brümmendorf, Tim H., Holyoake, Tessa L., Rufer, Nathalie, Barnett, Michael J., Schulzer, Michael, Eaves, Connie J., Eaves, Allen C., Lansdorp, Peter M.

“…Chronic myeloid leukemia (CML) is a clonal, multilineage myeloproliferative disorder characterized by the Philadelphia chromosome (Ph) and a marked expansion…”
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Tolerability of high dose chemotherapy and autologous stem cell transplantation in elderly patients with multiple myeloma: A single-center retrospective analysis by Wiebach, H., Gezer, D., Brummendorf, T.H., Crysandt, M., Wilop, S.

“…In the past years, high dose chemotherapy (HDT) with autologous stem cell transplantation (ASCT)has more extensively been performed in elderly patients with…”
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Communication patterns in families affected by parental cancer from the healthy parents’ perspective—process evaluation of the complex intervention Family-SCOUT by Heier, L., Weiß, J., Heuser, C., Nakata, H., Brock-Midding, E., Horbach-Bremen, R., Brümmendorf, T. H., Brüne, M., Dohmen, M., Drueke, B., Geiser, F., Holsteg, S., Icks, A., Karger, A., Panse, J., Petermann-Meyer, A., Viehmann, A., Ernstmann, N.

“…Purpose Within families affected by parental cancer, open communication impacts the well-being of parents and their children; however, limited research exists…”
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Gene expression profiling of normal hematopoietic progenitor cells under treatment with imatinib in vitro by Balabanov, S, Bartolovic, K, Komor, M, Kanz, L, Hofmann, W K, Brümmendorf, T H

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Genetic characterization of acquired aplastic anemia by targeted sequencing by Heuser, Michael, Schlarmann, Carola, Dobbernack, Vera, Panagiota, Victoria, Wiehlmann, Lutz, Walter, Carolin, Beier, Fabian, Ziegler, Patrick, Yun, Haiyang, Kade, Sofia, Kirchner, Aylin, Huang, Liu, Koenecke, Christian, Eder, Matthias, Brümmendorf, Tim H, Dugas, Martin, Ganser, Arnold, Thol, Felicitas

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Expression of MUC-1 Epitopes on Normal Bone Marrow: Implications for the Detection of Micrometastatic Tumor Cells by BRUGGER, W, BÜHRING, H.-J, SCHEDING, S, KANZ, L, GRÜNEBACH, F, VOGEL, W, KAUL, S, MÜLLER, R, BRÜMMENDORF, T. H, ZIEGLER, B. L, RAPPOLD, I, BROSSART, P

“…The expression of the carcinoma-associated mucin MUC-1 is thought to be restricted to epithelial cells and is used for micrometastatic tumor cell detection in…”
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Telomere length dynamics in normal hematopoiesis and in disease states characterized by increased stem cell turnover by BRÜMMENDORF, T. H, BALABANOV, S

“…Telomeres both reflect and limit the replicative lifespan of normal somatic cells. Immature sub-populations of human CD34+38- hematopoietic stem cell (HSC) can…”
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Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML by Schütz, C, Inselmann, S, Saussele, S, Dietz, C T, Müller, M C, Eigendorff, E, Brendel, C A, Metzelder, S K, Brümmendorf, T H, Waller, C, Dengler, J, Goebeler, M E, Herbst, R, Freunek, G, Hanzel, S, Illmer, T, Wang, Y, Lange, T, Finkernagel, F, Hehlmann, R, Huber, M, Neubauer, A, Hochhaus, A, Guilhot, J, Mahon, F X, Pfirrmann, M, Burchert, A

“…This corrects the article DOI: 10.1038/leu.2017.9…”
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Telomere length analysis in monocytes and lymphocytes from patients with systemic lupus erythematosus using multi-color flow-FISH by Beier, F., Balabanov, S., Amberger, C.C., Hartmann, U., Manger, K., Dietz, K., Kötter, I., Brummendorf, T.H.

“…In order to analyse telomere length in subsets of human peripheral blood lymphocytes and monocytes, we modified a recently developed multicolor flow-…”
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Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells by Brummendorf, T H, Dragowska, W, Zijlmans JMJM, Thornbury, G, Lansdorp, P M

“…Hematopoietic stem cells (HSCs) in adult marrow are believed to be derived from fetal liver precursors. To study cell kinetics involved in long-term…”
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CD8+ T cells in large granular lymphocyte leukemia are not defective in activation- and replication-related apoptosis by Melenhorst, J.J, Brümmendorf, T.H, Kirby, M, Lansdorp, P.M, Barrett, A.J

“…Persistent lymphocytosis in large granular lymphocyte leukemia (LGL) may result from defects in activation- or Fas crosslinking-induced cell death. Here we…”
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Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood by Rufer, N, Brümmendorf, T H, Kolvraa, S, Bischoff, C, Christensen, K, Wadsworth, L, Schulzer, M, Lansdorp, P M

“…To study telomere length dynamics in hematopoietic cells with age, we analyzed the average length of telomere repeat sequences in diverse populations of…”
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