Search Results - "Brumme, Zabrina L"

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1 by Horvath, Riley M., Brumme, Zabrina L., Sadowski, Ivan

“…Expression of the HIV-1 genome by RNA Polymerase II is regulated at multiple steps, as are most cellular genes, including recruitment of general transcription…”
Get full text

Rapid Detection of SARS-CoV-2 Variants of Concern, Including B.1.1.28/P.1, British Columbia, Canada by Matic, Nancy, Lowe, Christopher F, Ritchie, Gordon, Stefanovic, Aleksandra, Lawson, Tanya, Jang, Willson, Young, Matthew, Dong, Winnie, Brumme, Zabrina L, Brumme, Chanson J, Leung, Victor, Romney, Marc G

“…To screen all severe acute respiratory syndrome coronavirus 2-positive samples in Vancouver, British Columbia, Canada, and determine whether they represented…”
Get full text

HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA) by Kinloch, Natalie N., Ren, Yanqin, Conce Alberto, Winiffer D., Dong, Winnie, Khadka, Pragya, Huang, Szu Han, Mota, Talia M., Wilson, Andrew, Shahid, Aniqa, Kirkby, Don, Harris, Marianne, Kovacs, Colin, Benko, Erika, Ostrowski, Mario A., Del Rio Estrada, Perla M., Wimpelberg, Avery, Cannon, Christopher, Hardy, W. David, MacLaren, Lynsay, Goldstein, Harris, Brumme, Chanson J., Lee, Guinevere Q., Lynch, Rebecca M., Brumme, Zabrina L., Jones, R. Brad

“…The Intact Proviral DNA Assay (IPDA) was developed to address the critical need for a scalable method for intact HIV-1 reservoir quantification. This droplet…”
Get full text

Influence of HLA-C Expression Level on HIV Control by Apps, Richard, Qi, Ying, Carlson, Jonathan M., Chen, Haoyan, Gao, Xiaojiang, Thomas, Rasmi, Yuki, Yuko, Del Prete, Greg Q., Goulder, Philip, Brumme, Zabrina L., Brumme, Chanson J., John, Mina, Mallal, Simon, Nelson, George, Bosch, Ronald, Heckerman, David, Stein, Judy L., Soderberg, Kelly A., Moody, M. Anthony, Denny, Thomas N., Zeng, Xue, Fang, Jingyuan, Moffett, Ashley, Lifson, Jeffrey D., Goedert, James J., Buchbinder, Susan, Kirk, Gregory D., Fellay, Jacques, McLaren, Paul, Deeks, Steven G., Pereyra, Florencia, Walker, Bruce, Michael, Nelson L., Weintrob, Amy, Wolinsky, Steven, Liao, Wilson, Carrington, Mary

“…A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also…”
Get full text

HIV-1 Vpu Mediates HLA-C Downregulation by Apps, Richard, Del Prete, Gregory Q., Chatterjee, Pramita, Lara, Abigail, Brumme, Zabrina L., Brockman, Mark A., Neil, Stuart, Pickering, Suzanne, Schneider, Douglas K., Piechocka-Trocha, Alicja, Walker, Bruce D., Thomas, Rasmi, Shaw, George M., Hahn, Beatrice H., Keele, Brandon F., Lifson, Jeffrey D., Carrington, Mary

“…Many pathogens evade cytotoxic T lymphocytes (CTLs) by downregulating HLA molecules on infected cells, but the loss of HLA can trigger NK cell-mediated lysis…”
Get full text

Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity by Rosás-Umbert, Miriam, Gunst, Jesper D., Pahus, Marie H., Olesen, Rikke, Schleimann, Mariane, Denton, Paul W., Ramos, Victor, Ward, Adam, Kinloch, Natalie N., Copertino, Dennis C., Escribà, Tuixent, Llano, Anuska, Brumme, Zabrina L., Brad Jones, R., Mothe, Beatriz, Brander, Christian, Fox, Julie, Nussenzweig, Michel C., Fidler, Sarah, Caskey, Marina, Tolstrup, Martin, Søgaard, Ole S.

“…In simian-human immunodeficiency virus (SHIV)-infected non-human primates, broadly neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell…”
Get full text

Older Adults Mount Less Durable Humoral Responses to Two Doses of COVID-19 mRNA Vaccine but Strong Initial Responses to a Third Dose by Mwimanzi, Francis, Lapointe, Hope R, Cheung, Peter K, Sang, Yurou, Yaseen, Fatima, Umviligihozo, Gisele, Kalikawe, Rebecca, Datwani, Sneha, Omondi, F Harrison, Burns, Laura, Young, Landon, Leung, Victor, Agafitei, Olga, Ennis, Siobhan, Dong, Winnie, Basra, Simran, Lim, Li Yi, Ng, Kurtis, Pantophlet, Ralph, Brumme, Chanson J, Montaner, Julio S G, Prystajecky, Natalie, Lowe, Christopher F, DeMarco, Mari L, Holmes, Daniel T, Simons, Janet, Niikura, Masahiro, Romney, Marc G, Brumme, Zabrina L, Brockman, Mark A

“…Abstract Background Third coronavirus disease 2019 (COVID-19) vaccine doses are broadly recommended, but immunogenicity data remain limited, particularly in…”
Get full text

HIV-1 variants are archived throughout infection and persist in the reservoir by Brooks, Kelsie, Jones, Bradley R, Dilernia, Dario A, Wilkins, Daniel J, Claiborne, Daniel T, McInally, Samantha, Gilmour, Jill, Kilembe, William, Joy, Jeffrey B, Allen, Susan A, Brumme, Zabrina L, Hunter, Eric

“…The HIV-1 reservoir consists of latently infected cells that persist despite antiretroviral therapy (ART). Elucidating the proviral genetic composition of the…”
Get full text

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection by Chen, Huabiao, Ndhlovu, Zaza M, Liu, Dongfang, Porter, Lindsay C, Fang, Justin W, Darko, Sam, Brockman, Mark A, Miura, Toshiyuki, Brumme, Zabrina L, Schneidewind, Arne, Piechocka-Trocha, Alicja, Cesa, Kevin T, Sela, Jennifer, Cung, Thai D, Toth, Ildiko, Pereyra, Florencia, Yu, Xu G, Douek, Daniel C, Kaufmann, Daniel E, Allen, Todd M, Walker, Bruce D

“…The functional basis of elite control of HIV is still unclear. Walker and colleagues show that elite controllers are tolerant of viral escape variants and more…”
Get full text

HIV proviral genetic diversity, compartmentalization and inferred dynamics in lung and blood during long-term suppressive antiretroviral therapy by Shahid, Aniqa, Jones, Bradley R, Yang, Julia S. W, Dong, Winnie, Shaipanich, Tawimas, Donohoe, Kathryn, Brumme, Chanson J, Joy, Jeffrey B, Leung, Janice M, Brumme, Zabrina L

“…The lung is an understudied site of HIV persistence. We isolated 898 subgenomic proviral sequences ( nef ) by single-genome approaches from blood and lung from…”
Get full text

SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells by Stevenson, Eva M., Terry, Sandra, Copertino, Dennis, Leyre, Louise, Danesh, Ali, Weiler, Jared, Ward, Adam R., Khadka, Pragya, McNeil, Evan, Bernard, Kevin, Miller, Itzayana G., Ellsworth, Grant B., Johnston, Carrie D., Finkelsztein, Eli J., Zumbo, Paul, Betel, Doron, Dündar, Friederike, Duncan, Maggie C., Lapointe, Hope R., Speckmaier, Sarah, Moran-Garcia, Nadia, Papa, Michelle Premazzi, Nicholes, Samuel, Stover, Carissa J., Lynch, Rebecca M., Caskey, Marina, Gaebler, Christian, Chun, Tae-Wook, Bosque, Alberto, Wilkin, Timothy J., Lee, Guinevere Q., Brumme, Zabrina L., Jones, R. Brad

“…Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by CD8 + cytotoxic T-cells. Clinical studies of latency reversing…”
Get full text

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity by Naicker, Delon, Sonela, Nelson, Jin, Steven W, Mulaudzi, Takalani, Ojwach, Doty, Reddy, Tarylee, Brockman, Mark A, Brumme, Zabrina L, Ndung'u, Thumbi, Mann, Jaclyn K

“…Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in…”
Get full text

HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy by Lee, Guinevere Q., Khadka, Pragya, Gowanlock, Sarah N., Copertino, Dennis C., Duncan, Maggie C., Omondi, F. Harrison, Kinloch, Natalie N., Kasule, Jingo, Kityamuweesi, Taddeo, Buule, Paul, Jamiru, Samiri, Tomusange, Stephen, Anok, Aggrey, Chen, Zhengming, Jones, R. Brad, Galiwango, Ronald M., Reynolds, Steven J., Quinn, Thomas C., Brumme, Zabrina L., Redd, Andrew D., Prodger, Jessica L.

“…The primary obstacle to curing HIV-1 is a reservoir of CD4+ cells that contain stably integrated provirus. Previous studies characterizing the proviral…”
Get full text

Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1 by Carlson, Jonathan M, Listgarten, Jennifer, Pfeifer, Nico, Tan, Vincent, Kadie, Carl, Walker, Bruce D, Ndung'u, Thumbi, Shapiro, Roger, Frater, John, Brumme, Zabrina L, Goulder, Philip J R, Heckerman, David

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
Get full text

Near full-length HIV sequencing in multiple tissues collected postmortem reveals shared clonal expansions across distinct reservoirs during ART by Dufour, Caroline, Ruiz, Maria Julia, Pagliuzza, Amélie, Richard, Corentin, Shahid, Aniqa, Fromentin, Rémi, Ponte, Rosalie, Cattin, Amélie, Wiche Salinas, Tomas Raul, Salahuddin, Syim, Sandstrom, Teslin, Schinkel, Stephanie Burke, Costiniuk, Cecilia T., Jenabian, Mohammad-Ali, Ancuta, Petronela, Routy, Jean-Pierre, Cohen, Éric A., Brumme, Zabrina L., Power, Christopher, Angel, Jonathan B., Chomont, Nicolas

“…HIV persists in tissues during antiretroviral therapy (ART), but the relative contribution of different anatomical compartments to the viral reservoir in…”
Get full text

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5 by Jin, Steven W, Mwimanzi, Francis M, Mann, Jaclyn K, Bwana, Mwebesa Bosco, Lee, Guinevere Q, Brumme, Chanson J, Hunt, Peter W, Martin, Jeff N, Bangsberg, David R, Ndung'u, Thumbi, Brumme, Zabrina L, Brockman, Mark A

“…HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our understanding of how naturally occurring global Nef sequence diversity…”
Get full text

T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics by Akahoshi, Tomohiro, Gatanaga, Hiroyuki, Kuse, Nozomi, Chikata, Takayuki, Koyanagi, Madoka, Ishizuka, Naoki, Brumme, Chanson J, Murakoshi, Hayato, Brumme, Zabrina L, Oka, Shinichi, Takiguchi, Masafumi

“…HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics…”
Get full text

HLA-B57/B5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition by Miura, Toshiyuki, Brockman, Mark A., Schneidewind, Arne, Lobritz, Michael, Pereyra, Florencia, Rathod, Almas, Block, Brian L., Brumme, Zabrina L., Brumme, Chanson J., Baker, Brett, Rothchild, Alissa C., Li, Bin, Trocha, Alicja, Cutrell, Emily, Frahm, Nicole, Brander, Christian, Toth, Ildiko, Arts, Eric J., Allen, Todd M., Walker, Bruce D.

“…Erratum ( vol. 83 , p. 5961 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
Get full text

Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination by Lapointe, Hope R., Mwimanzi, Francis, Cheung, Peter K., Sang, Yurou, Yaseen, Fatima, Kalikawe, Rebecca, Datwani, Sneha, Waterworth, Rachel, Umviligihozo, Gisele, Ennis, Siobhan, Young, Landon, Dong, Winnie, Kirkby, Don, Burns, Laura, Leung, Victor, Holmes, Daniel T., DeMarco, Mari L., Simons, Janet, Matic, Nancy, Montaner, Julio S.G., Brumme, Chanson J., Prystajecky, Natalie, Niikura, Masahiro, Lowe, Christopher F., Romney, Marc G., Brockman, Mark A., Brumme, Zabrina L.

“…SARS-CoV-2 Omicron infections are common among individuals who are vaccinated or have recovered from prior variant infection, but few reports have…”
Get full text

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins by Brumme, Zabrina L, John, Mina, Carlson, Jonathan M, Brumme, Chanson J, Chan, Dennison, Brockman, Mark A, Swenson, Luke C, Tao, Iris, Szeto, Sharon, Rosato, Pamela, Sela, Jennifer, Kadie, Carl M, Frahm, Nicole, Brander, Christian, Haas, David W, Riddler, Sharon A, Haubrich, Richard, Walker, Bruce D, Harrigan, P Richard, Heckerman, David, Mallal, Simon

“…Despite the extensive genetic diversity of HIV-1, viral evolution in response to immune selective pressures follows broadly predictable mutational patterns…”
Get full text