Search Results - "Brumlik, Michael J"

An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance by Mitra, Doyel, Brumlik, Michael J, Okamgba, Stella U, Zhu, Yun, Duplessis, Tamika T, Parvani, Jenny G, Lesko, Samuel M, Brogi, Edi, Jones, Frank E

“…The HER2-targeted therapy trastuzumab is widely used for the treatment of patients with metastatic breast tumors overexpressing HER2. However, an objective…”
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Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice by HUREZ, Vincent, DANIEL, Benjamin J, WALL, Shawna, BRUMLIK, Michael J, SHIN, Tahiro, BIN ZHANG, CURIEL, Tyler J, LISHI SUN, LIU, Ai-Jie, LUDWIG, Sara M, KIOUS, Mark J, THIBODEAUX, Suzanne R, PANDESWARA, Srilakshmi, MURTHY, Kruthi, LIVI, Carolina B

“…Although cancer tends to affect the elderly, most preclinical studies are carried out in young subjects. In this study, we developed a melanoma-specific cancer…”
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Costimulator B7-DC Attenuates Strong Th2 Responses Induced by Nippostrongylus brasiliensis by Ishiwata, Kenji, Watanabe, Naohiro, Guo, Miao, Tomihara, Kei, Brumlik, Michael J, Yagita, Hideo, Pardoll, Drew, Chen, Lieping, Shin, Tahiro

“…The caliber and magnitude of T cell responses are regulated by costimulatory molecules following the engagement of TCRs and MHC molecules. B7-DC has the…”
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Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells by Tomihara, Kei, Guo, Miao, Shin, Takako, Sun, Xiuhua, Ludwig, Sara M, Brumlik, Michael J, Zhang, Bin, Curiel, Tyler J, Shin, Tahiro

“…Both innate and adaptive immune systems are considered important for cancer prevention, immunosurveillance, and control of cancer progression. It is known…”
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Drugs Designed To Inhibit Human p38 Mitogen-Activated Protein Kinase Activation Treat Toxoplasma gondii and Encephalitozoon cuniculi Infection by SHUANG WEI, DANIEL, Benjamin J, BRUMLIK, Michael J, BUROW, Matthew E, WEIPING ZOU, KHAN, Imtiaz A, WADSWORTH, Scott, SIEKIERKA, John, CURIEL, Tyler J

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IFNα Augments Clinical Efficacy of Regulatory T-cell Depletion with Denileukin Diftitox in Ovarian Cancer by Thibodeaux, Suzanne R, Barnett, Brian B, Pandeswara, Srilakshmi, Wall, Shawna R, Hurez, Vincent, Dao, Vinh, Sun, Lishi, Daniel, Benjamin J, Brumlik, Michael J, Drerup, Justin, Padrón, Álvaro, Whiteside, Teresa, Kryczek, Ilona, Zou, Weiping, Curiel, Tyler J

“…Immunotherapy treats some cancers, but not ovarian cancer. Regulatory T cells (Tregs) impede anti-ovarian cancer immunity but effective human Treg-directed…”
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Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines by Ruter, Jens, Barnett, Brian G, Kryczek, Ilona, Brumlik, Michael J, Daniel, Benjamin J, Coukos, George, Zou, Weiping, Curiel, Tyler J

“…Cancers express tumor associated antigens that should elicit immune attack, but spontaneous immune rejection of established cancer is rare. Recent data…”
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Parasite Mitogen-Activated Protein Kinases as Drug Discovery Targets to Treat Human Protozoan Pathogens by Brumlik, Michael J., Pandeswara, Srilakshmi, Ludwig, Sara M., Murthy, Kruthi, Curiel, Tyler J.

“…Protozoan pathogens are a highly diverse group of unicellular organisms, several of which are significant human pathogens. One group of protozoan pathogens…”
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Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication by Brumlik, Michael J., Nkhoma, Standwell, Kious, Mark J., Thompson, George R., Patterson, Thomas F., Siekierka, John J., Anderson, Tim J.C., Curiel, Tyler J.

“…[Display omitted] ► RWJ68198 and RWJ67657 inhibit Plasmodium falciparum replication. ► These p38 MAPK inhibitors interfere with parasite stage differentiation…”
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TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production by Brumlik, Michael J., Pandeswara, Srilakshmi, Ludwig, Sara M., Jeansonne, Duane P., Lacey, Michelle R., Murthy, Kruthi, Daniel, Benjamin J., Wang, Rong-Fu, Thibodeaux, Suzanne R., Church, Kristina M., Hurez, Vincent, Kious, Mark J., Zhang, Bin, Alagbala, Adebusola, Xia, Xiaojun, Curiel, Tyler J.

“…•TgMAPK1 is a Toxoplasma gondii mitogen-activated protein kinase (MAPK).•It affects parasite proliferation in an IFN-γ, iNOS and MKK3-dependent…”
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Early Cephamycin Biosynthetic Genes Are Expressed from a Polycistronic Transcript in Streptomyces clavuligerus by Alexander, D C, Brumlik, M J, Lee, L, Jensen, S E

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Toxoplasma gondii expresses two mitogen-activated protein kinase genes that represent distinct protozoan subfamilies by Lacey, Michelle R, Brumlik, Michael J, Yenni, Rachael E, Burow, Matthew E, Curiel, Tyler J

“…All eukaryotes express mitogen-activated protein kinases (MAPKs) that govern diverse cellular processes including proliferation, differentiation, and survival…”
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Regulatory T cells: a new frontier in cancer immunotherapy by Barnett, Brian G, Rüter, Jens, Kryczek, Ilona, Brumlik, Michael J, Cheng, Pui Joan, Daniel, Benjamin J, Coukos, George, Zou, Weiping, Curiel, Tyler J

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Trends in immunoconjugate and ligand-receptor based targeting development for cancer therapy by Brumlik, Michael J, Daniel, Benjamin J, Waehler, Reinhard, Curiel, David T, Giles, Francis J, Curiel, Tyler J

“…Many agents used to treat cancer are toxic to normal tissues. Thus, treatments delivering drug specifically to tumour, while minimising exposure to normal…”
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A simple method to detect Toxoplasma gondii-specific cytotoxic T cells in vivo by DANIEL, Benjamin J, PANDESWARA, Srilakshmi, BRUMLIK, Michael J, LIU, Aijie, THIBODEAUX, Suzanne R, LUDWIG, Sara M, XIUHUA SUN, CURIEL, Tyler J

“…Cytotoxic T cells (CTLs) are an important component of adaptive immunity. The study of antigen-specific CTLs in vivo is desirable yet difficult. Identification…”
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A simple method to detect Toxopl a sma gondii-specific cytotoxic T cells in vivo by Daniel, Benjamin J., Pandeswara, Srilakshmi, Brumlik, Michael J., Liu, AiJie, Thibodeaux, Suzanne R., Ludwig, Sara M., Sun, Xiuhua, Curiel, Tyler J.

“…Cytotoxic T cells (CTLs) are an important component of adaptive immunity. The study of antigen-specific CTLs in vivo is desirable yet difficult. Identification…”
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Identification of a novel mitogen-activated protein kinase in Toxoplasma gondii by Brumlik, Michael J., Wei, Shuang, Finstad, Kristiaan, Nesbit, Jacqueline, Hyman, Linda E., Lacey, Michelle, Burow, Matthew E., Curiel, Tyler J.

“…Toxoplasma gondii is an Apicomplexan parasite causing significant morbidity and mortality in immunocompromised hosts. Mitogen activated protein kinases…”
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Use of long-range repetitive element polymorphism-PCR to differentiate Bacillus anthracis strains by BRUMLIK, Michael J, SZYMAJDA, Urszula, ZAKOWSKA, Dorota, XUDONG LIANG, REDKAR, Rajendra J, PATRA, Guy, DEL VECCHIO, Vito G

“…The genome of Bacillus anthracis is extremely monomorphic, and thus individual strains have often proven to be recalcitrant to differentiation at the molecular…”
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Identification of the catalytic triad of the lipase/acyltransferase from Aeromonas hydrophila by Brumlik, M J, Buckley, J T

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The disulfide bond in the Aeromonas hydrophila lipase/acyltransferase stabilizes the structure but is not required for secretion or activity by Brumlik, M J, van der Goot, F G, Wong, K R, Buckley, J T

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