Search Results - "Brumaghim, Julia L."

Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding by Perron, Nathan R, Brumaghim, Julia L

“…In this review, primary attention is given to the antioxidant (and prooxidant) activity of polyphenols arising from their interactions with iron both in vitro…”
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Antioxidant Activity of Sulfur and Selenium: A Review of Reactive Oxygen Species Scavenging, Glutathione Peroxidase, and Metal-Binding Antioxidant Mechanisms by Battin, Erin E., Brumaghim, Julia L.

“…It is well known that oxidation caused by reactive oxygen species (ROS) is a major cause of cellular damage and death and has been implicated in cancer,…”
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Reactive oxygen species generation by copper(II) oxide nanoparticles determined by DNA damage assays and EPR spectroscopy by Angelé-Martínez, Carlos, Nguyen, Khanh Van T., Ameer, Fathima S., Anker, Jeffrey N., Brumaghim, Julia L.

“…Copper(II) oxide nanoparticles ( NP CuO) have many industrial applications, but are highly cytotoxic because they generate reactive oxygen species (ROS). It is…”
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Fluconazole induces ROS in Cryptococcus neoformans and contributes to DNA damage in vitro by Peng, Congyue Annie, Gaertner, Andrea A E, Henriquez, Sarah Ana, Fang, Diana, Colon-Reyes, Rodney J, Brumaghim, Julia L, Kozubowski, Lukasz

“…Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromised individuals. Fluconazole (FLC) is a fungistatic drug…”
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Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds by Ramoutar, Ria R, Brumaghim, Julia L

“…Inorganic selenium and oxo-sulfur compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer…”
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Metal specificity in DNA damage prevention by sulfur antioxidants by Battin, Erin E., Brumaghim, Julia L.

“…Metals such as Cu I and Fe II generate hydroxyl radical ( OH) by reducing endogenous hydrogen peroxide (H 2O 2). Because antioxidants can ameliorate…”
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The Central Role of Metal Coordination in Selenium Antioxidant Activity by Battin, Erin E, Perron, Nathan R, Brumaghim, Julia L

“…Oxidative DNA damage occurs in vivo by hydroxyl radical generated in metal-mediated Fenton-type reactions. Cell death and mutation caused by this DNA damage…”
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Prevention of iron- and copper-mediated DNA damage by catecholamine and amino acid neurotransmitters, L-DOPA, and curcumin: metal binding as a general antioxidant mechanism by García, Carla R, Angelé-Martínez, Carlos, Wilkes, Jenna A, Wang, Hsiao C, Battin, Erin E, Brumaghim, Julia L

“…Concentrations of labile iron and copper are elevated in patients with neurological disorders, causing interest in metal-neurotransmitter interactions…”
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Sulfur and selenium antioxidants: Challenging radical scavenging mechanisms and developing structure–activity relationships based on metal binding by Zimmerman, Matthew T., Bayse, Craig A., Ramoutar, Ria R., Brumaghim, Julia L.

“…Because sulfur and selenium antioxidants can prevent oxidative damage, numerous animal and clinical trials have investigated the ability of these compounds to…”
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Encapsulation and Stabilization of Reactive Aromatic Diazonium Ions and the Tropylium Ion Within a Supramolecular Host by Brumaghim, Julia L., Michels, Martin, Pagliero, Daniela, Raymond, Kenneth N.

“…Supramolecular assemblies with internal cavities are being developed as nanoscale reaction vessels to protect or modify the reactivity of guest species through…”
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Hydrophobic Chemistry in Aqueous Solution: Stabilization and Stereoselective Encapsulation of Phosphonium Guests in a Supramolecular Host by Brumaghim, Julia L., Michels, Martin, Raymond, Kenneth N.

“…Encapsulation of guest molecules inside supramolecular host assemblies provides a way to stabilize reactive species in aqueous solution. The stabilization of…”
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Correlating Quantitative Measurements of Radical Production by Photocatalytic TiO2 with Daphnia magna Toxicity by Coral, Jason A., Kitchens, Christopher L., Brumaghim, Julia L., Klaine, Stephen J.

“…Increased use of titanium dioxide (TiO2) nanoparticles (NPs) in domestic and industrial applications has increased the risk for adverse environmental outcomes…”
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Cobalt-mediated oxidative DNA damage and its prevention by polyphenol antioxidants by Angelé-Martínez, Carlos, Murray, Joseph, Stewart, Paul A., Haines, Jennifer, Gaertner, Andrea A.E., Brumaghim, Julia L.

“…Although cobalt is a required nutrient, it is toxic due to its ability to generate reactive oxygen species (ROS) and damage DNA. ROS generation by Co2+ often…”
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Correlating Quantitative Measurements of Radical Production by Photocatalytic TiO 2 with Daphnia magna Toxicity by Coral, Jason A, Kitchens, Christopher L, Brumaghim, Julia L, Klaine, Stephen J

“…Increased use of titanium dioxide (TiO ) nanoparticles (NPs) in domestic and industrial applications has increased the risk for adverse environmental outcomes…”
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Dinuclear copper(I) complexes with N-heterocyclic thione and selone ligands: synthesis, characterization, and electrochemical studies by Kimani, Martin M, Watts, David, Graham, Leigh A, Rabinovich, Daniel, Yap, Glenn P A, Brumaghim, Julia L

“…The synthesis, characterization, and structures of a series of homoleptic and heteroleptic copper(I) complexes supported by N-heterocyclic chalcogenone ligands…”
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Probing the Antioxidant Action of Selenium and Sulfur Using Cu(I)-Chalcogenone Tris(pyrazolyl)methane and -borate Complexes by Kimani, Martin M, Brumaghim, Julia L, VanDerveer, Don

“…Hydroxyl radical generated from the reaction of Cu+ with hydrogen peroxide results in oxidative DNA damage, and this damage is implicated in aging, cancer, and…”
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Predicting How Polyphenol Antioxidants Prevent DNA Damage by Binding to Iron by Perron, Nathan R, Hodges, James N, Jenkins, Michael, Brumaghim, Julia L

“…Prevention of oxidative DNA damage due to hydroxyl radical is important for the prevention and treatment of disease. Because of their widely recognized…”
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Disulfide Versus Diselenide Complexes of Copper: Air-Free and Air-Exposed Syntheses Result in Variable Ligands and Coordination by Murphy, Jaime M., Owen, Amanda M., McMillen, Colin D., Brumaghim, Julia L.

“…Reactions of bis (1-methylimidazole-2)disulfide (MMI DS ) or bis (1-methylimidazole-2)diselenide (MMI DSe ) with Cu(I) result in a variety of products…”
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Kinetics of iron oxidation upon polyphenol binding by Perron, Nathan R, Wang, Hsiao C, Deguire, Sean N, Jenkins, Michael, Lawson, Mereze, Brumaghim, Julia L

“…Polyphenol prevention of iron-mediated DNA damage occurs primarily through iron binding. Once bound, iron in the Fe(2+)-polyphenol complex autooxidizes to…”
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Polyphenol effects on CuO-nanoparticle-mediated DNA damage, reactive oxygen species generation, and fibroblast cell death by Angelé-Martínez, Carlos, Ameer, Fathima S., Raval, Yash S., Huang, Guohui, Tzeng, Tzuen-Rong J., Anker, Jeffrey N., Brumaghim, Julia L.

“…The ability of ten polyphenolic antioxidants to prevent CuO nanoparticle (NPCuO) and H2O2-mediated DNA damage and cytotoxicity was investigated. Five of the…”
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