Search Results - "Brum, Pedro Ozorio"

Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells by Somensi, Nauana, Brum, Pedro Ozorio, de Miranda Ramos, Vitor, Gasparotto, Juciano, Zanotto-Filho, Alfeu, Rostirolla, Diana Carolina, da Silva Morrone, Maurilio, Moreira, José Claudio Fonseca, Pens Gelain, Daniel

“…Background/Aims: Heat shock protein 70 (HSP70) has been recently described with extracellular actions, where it is actively released in inflammatory…”
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Role of toll-like receptor 4 and sex in 6-hydroxydopamine–induced behavioral impairments and neurodegeneration in mice by Somensi, Nauana, Lopes, Samantha Cristiane, Gasparotto, Juciano, Mayer Gonçalves, Rosângela, Tiefensee-Ribeiro, Camila, Oppermann Peixoto, Daniel, Ozorio Brum, Pedro, Pinho, Cibele Martins, Agnes, Jonathan Paulo, Santos, Lucas, de Oliveira, Jade, Spiller, Fernando, Fonseca Moreira, José Cláudio, Zanotto-Filho, Alfeu, Prediger, Rui Daniel, Pens Gelain, Daniel

“…Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of the nigrostriatal dopaminergic neurons that are associated with…”
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Hypoxia-Inducible Factor-1α (HIF-1α) Inhibition Impairs Retinoic Acid-Induced Differentiation in SH-SY5Y Neuroblastoma Cells, Leading to Reduced Neurite Length and Diminished Gene Expression Related to Cell Differentiation by Brum, Pedro Ozorio, Viola, Guilherme Danielski, Saibro-Girardi, Carolina, Tiefensee-Ribeiro, Camila, Brum, Matheus Ozorio, Gasparotto, Juciano, Krolow, Rachel, Moreira, José Cláudio Fonseca, Gelain, Daniel Pens

“…Neuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic…”
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Intranasal HSP70 administration protects against dopaminergic denervation and modulates neuroinflammatory response in the 6-OHDA rat model by Tiefensee Ribeiro, Camila, Peixoto, Daniel Oppermann, Santos, Lucas, Saibro-Girardi, Carolina, Brum, Pedro Ozorio, Carazza-Kessler, Flávio Gabriel, Somensi, Nauana, Behrens, Luiza Marques Prates, Bittencourt, Reykla Ramon, Soares, Laíssa Santos, Silveira, Alexandre Kleber, de Oliveira, Jade, Moreira, José Cláudio Fonseca, Gasparotto, Juciano, Gelain, Daniel Pens

“…HSP70 is one of the main molecular chaperones involved in the cellular stress response. Besides its chaperone action, HSP70 also modulates the immune response…”
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High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress by Bittencourt, Aline, Brum, Pedro Ozorio, Ribeiro, Camila Tiefensee, Gasparotto, Juciano, Bortolin, Rafael Calixto, de Vargas, Amanda Rodrigues, Heimfarth, Luana, de Almeida, Roberto Farina, Moreira, José Claudio Fonseca, de Oliveira, Jade, Gelain, Daniel Pens

“…Obesity is a health problem that has been associated with neuroinflammation, decreased cognitive functions and development of neurodegenerative diseases…”
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Increased alpha‐synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE) by Peixoto, Daniel Oppermann, Bittencourt, Reykla Ramon, Gasparotto, Juciano, Kessler, Flávio Gabriel Carazza, Brum, Pedro Ozorio, Somensi, Nauana, Girardi, Carolina Saibro, Santos da Silva, Lucas, Outeiro, Tiago Fleming, Moreira, José Cláudio Fonseca, Gelain, Daniel Pens

“…The receptor for advanced glycation end products (RAGE) is a protein of the immunoglobulin superfamily capable of regulating inflammation. Considering the role…”
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Transgenerational inheritance of methylmercury and vitamin A-induced toxicological effects in a Wistar rats environmental-based model by Carazza-Kessler, Flávio Gabriel, Campos, Marlene Soares, Bittencourt, Reykla Ramon, Rosa-Silva, Helen Taís da, Brum, Pedro Ozorio, Silveira, Alexandre Kléber, Teixeira, Alexsander Alves, Ribeiro, Camila Tiefensee, Peixoto, Daniel Oppermann, Santos, Lucas, Andrade, Giovanni, Panzenhagen, Alana Castro, Scheibel, Ingrid Matsubara, Gelain, Daniel Pens, Fonseca Moreira, José Cláudio

“…Mercury (Hg) and vitamin A (VitA) are two environmental factors with potential health impacts, especially during pregnancy and early childhood. Fish and…”
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Histone 3 Trimethylation Patterns are Associated with Resilience or Stress Susceptibility in a Rat Model of Major Depression Disorder by Santos, Lucas, Behrens, Luiza, Barbosa, Camila, Tiefensee-Ribeiro, Camila, Rosa-Silva, Helen, Somensi, Nauana, Brum, Pedro Ozorio, Silveira, Alexandre Kleber, Rodrigues, Matheus Scarpatto, de Oliveira, Jade, Gelain, Daniel Pens, Almeida, Roberto F, Moreira, José Cláudio Fonseca

“…Major Depressive Disorder (MDD) is a severe and multifactorial psychiatric condition. Evidence has shown that environmental factors, such as stress,…”
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Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease by Gasparotto, Juciano, Senger, Mario Roberto, Telles de Sá Moreira, Emilio, Brum, Pedro Ozorio, Carazza Kessler, Flávio Gabriel, Peixoto, Daniel Oppermann, Panzenhagen, Alana Castro, Ong, Lin Kooi, Campos Soares, Marlene, Reis, Patricia Alves, Schirato, Giuliana Viegas, Góes Valente, Walter César, Araújo Montoya, Bogar Omar, Silva, Floriano P., Fonseca Moreira, José Claudio, Dal-Pizzol, Felipe, Castro-Faria-Neto, Hugo C., Gelain, Daniel Pens

“…Schistosomiasis, a neglected tropical disease caused by trematodes of the Schistosoma genus, affects over 250 million people around the world. This disease has…”
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Nuclear RXRα and RXRβ receptors exert distinct and opposite effects on RA-mediated neuroblastoma differentiation by Girardi, Carolina Saibro, Rostirolla, Diana Carolina, Lini, Fernanda Janini Mota, Brum, Pedro Ozorio, Delgado, Jeferson, Ribeiro, Camila Tiefensee, Teixeira, Alexsander Alves, Peixoto, Daniel Oppermann, Heimfarth, Luana, Kunzler, Alice, Moreira, José Cláudio Fonseca, Gelain, Daniel Pens

“…Retinoic acid (RA) promotes differentiation in multiple neurogenic cell types by promoting gene reprogramming through retinoid receptors and also by inducing…”
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Oral administration of carvacrol/β-cyclodextrin complex protects against 6-hydroxydopamine-induced dopaminergic denervation by Tiefensee Ribeiro, Camila, Gasparotto, Juciano, Petiz, Lyvia Lintzmaier, Brum, Pedro Ozorio, Peixoto, Daniel Oppermann, Kunzler, Alice, da Rosa Silva, Helen Tais, Bortolin, Rafael Calixto, Almeida, Roberto Farina, Quintans-Junior, Lucindo José, Araújo, Adriano Antunes, Moreira, José Claudio Fonseca, Gelain, Daniel Pens

“…Carvacrol (CARV) presents valuable biological properties such as anti-inflammatory and antioxidant activities. However, pharmacological uses of CARV are…”
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