Search Results - "Brullo, Chiara"

Amino-Pyrazoles in Medicinal Chemistry: A Review by Lusardi, Matteo, Spallarossa, Andrea, Brullo, Chiara

“…A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential. Consequently, the search for new pyrazole-based compounds is of great…”
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The Development of BTK Inhibitors: A Five-Year Update by Tasso, Bruno, Spallarossa, Andrea, Russo, Eleonora, Brullo, Chiara

“…Bruton's tyrosine kinase (BTK) represented, in the past ten years, an important target for the development of new therapeutic agents that could be useful for…”
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Vascular Endothelial Growth Factor (VEGF) Receptors: Drugs and New Inhibitors by Musumeci, Francesca, Radi, Marco, Brullo, Chiara, Schenone, Silvia

“…The recent launch onto the market of five VEGFR inhibitors indicates the therapeutic value of these agents and the importance of the research in the field of…”
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Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective by Brullo, Chiara, Villa, Carla, Tasso, Bruno, Russo, Eleonora, Spallarossa, Andrea

“…In the past few years, Bruton’s tyrosine Kinase (Btk) has emerged as new target in medicinal chemistry. Since approval of ibrutinib in 2013 for treatment of…”
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PDE4D: A Multipurpose Pharmacological Target by Lusardi, Matteo, Rapetti, Federica, Spallarossa, Andrea, Brullo, Chiara

“…Phosphodiesterase 4 (PDE4) enzymes catalyze cyclic adenosine monophosphate (cAMP) hydrolysis and are involved in a variety of physiological processes,…”
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Computational Methods for the Discovery and Optimization of TAAR1 and TAAR5 Ligands by Scarano, Naomi, Espinoza, Stefano, Brullo, Chiara, Cichero, Elena

“…G-protein-coupled receptors (GPCRs) represent a family of druggable targets when treating several diseases and continue to be a leading part of the drug…”
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Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry by Brullo, Chiara, Rapetti, Federica, Bruno, Olga

“…The pyrazole nucleus has long been known as a privileged scaffold in the synthesis of biologically active compounds. Within the numerous pyrazole derivatives…”
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Nanotechnology of Tyrosine Kinase Inhibitors in Cancer Therapy: A Perspective by Russo, Eleonora, Spallarossa, Andrea, Tasso, Bruno, Villa, Carla, Brullo, Chiara

“…Nanotechnology is an important application in modern cancer therapy. In comparison with conventional drug formulations, nanoparticles ensure better penetration…”
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Hydrogel Formulations of Antibacterial Pyrazoles Using a Synthesized Polystyrene-Based Cationic Resin as a Gelling Agent by Alfei, Silvana, Zuccari, Guendalina, Russo, Eleonora, Villa, Carla, Brullo, Chiara

“…Here, to develop new topical antibacterial formulations to treat staphylococcal infections, two pyrazoles ( and ) previously reported as antibacterial agents,…”
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Nanotechnology for Pediatric Retinoblastoma Therapy by Russo, Eleonora, Spallarossa, Andrea, Tasso, Bruno, Villa, Carla, Brullo, Chiara

“…Retinoblastoma is a rare, sometimes hereditary, pediatric cancer. In high-income countries this disease has a survival rate approaching 100%, while in low- and…”
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The Development of FAK Inhibitors: A Five-Year Update by Spallarossa, Andrea, Tasso, Bruno, Russo, Eleonora, Villa, Carla, Brullo, Chiara

“…Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase over-expressed in different solid cancers. In recent years, FAK has been recognized as a new…”
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New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways by Signorello, Maria Grazia, Rapetti, Federica, Meta, Elda, Sidibè, Adama, Bruno, Olga, Brullo, Chiara

“…(1) Background: different previously synthesized pyrazoles and imidazo-pyrazoles showed interesting anti-angiogenic action, being able to interfere with…”
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Targeting USP-7 by a Novel Fluorinated 5-Pyrazolyl-Urea Derivative by Morretta, Elva, Brullo, Chiara, Belvedere, Raffaella, Petrella, Antonello, Spallarossa, Andrea, Monti, Maria Chiara

“…The impact of innovative technologies on the target discovery has been employed here to characterize the interactome of STIRUR 41, a promising…”
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Preparation and Physicochemical Characterization of Water-Soluble Pyrazole-Based Nanoparticles by Dendrimer Encapsulation of an Insoluble Bioactive Pyrazole Derivative by Alfei, Silvana, Brullo, Chiara, Caviglia, Debora, Zuccari, Guendalina

“…2-(4-Bromo-3,5-diphenyl-pyrazol-1-yl)-ethanol (BBB4) was synthetized and successfully evaluated concerning numerous biological activities, except for…”
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Pyrazole-Enriched Cationic Nanoparticles Induced Early- and Late-Stage Apoptosis in Neuroblastoma Cells at Sub-Micromolar Concentrations by Zuccari, Guendalina, Zorzoli, Alessia, Marimpietri, Danilo, Brullo, Chiara, Alfei, Silvana

“…Neuroblastoma (NB) is a severe form of tumor occurring mainly in young children and originating from nerve cells found in the abdomen or next to the spine. NB…”
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Anticancer Effects of the Novel Pyrazolyl-Urea GeGe-3 by Williams, Ashleigh, Cooper, Emma, Clark, Bethany, Perry, Laura, Ponassi, Marco, Iervasi, Erika, Brullo, Chiara, Greenhough, Alexander, Ladomery, Michael

“…In a screen of over 200 novel pyrazole compounds, ethyl 1-(2-hydroxypentyl)-5-(3-(3-(trifluoromethyl) phenyl)ureido)-1 -pyrazole-4-carboxylate (named GeGe-3)…”
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Structure-Activity Relationship Studies on Highly Functionalized Pyrazole Hydrazones and Amides as Antiproliferative and Antioxidant Agents by Lusardi, Matteo, Signorello, Maria Grazia, Russo, Eleonora, Caviglia, Debora, Ponassi, Marco, Iervasi, Erika, Rosano, Camillo, Brullo, Chiara, Spallarossa, Andrea

“…Aminopyrazoles represent interesting structures in medicinal chemistry, and several derivatives showed biological activity in different therapeutic areas…”
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Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors by Scarano, Naomi, Abbotto, Elena, Musumeci, Francesca, Salis, Annalisa, Brullo, Chiara, Fossa, Paola, Schenone, Silvia, Bruzzone, Santina, Cichero, Elena

“…Sirtuin isoform 2 (SIRT2) is one of the seven sirtuin isoforms present in humans, being classified as class III histone deacetylases (HDACs). Based on the high…”
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Imidazo-Pyrazole-Loaded Palmitic Acid and Polystyrene-Based Nanoparticles: Synthesis, Characterization and Antiproliferative Activity on Chemo-Resistant Human Neuroblastoma Cells by Valenti, Giulia Elda, Marengo, Barbara, Milanese, Marco, Zuccari, Guendalina, Brullo, Chiara, Domenicotti, Cinzia, Alfei, Silvana

“…Neuroblastoma (NB) is a childhood cancer, commonly treated with drugs, such as etoposide (ETO), whose efficacy is limited by the onset of resistance. Here,…”
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Antimicrobial Evaluation of New Pyrazoles, Indazoles and Pyrazolines Prepared in Continuous Flow Mode by Burke, Adam, Di Filippo, Mara, Spiccio, Silvia, Schito, Anna Maria, Caviglia, Debora, Brullo, Chiara, Baumann, Marcus

“…Multi-drug resistant bacterial strains (MDR) have become an increasing challenge to our health system, resulting in multiple classical antibiotics being…”
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