Search Results - "Bruinsma, Rica"

Abstract 5499: Kinase inhibitor selectivity profiling utilizing a versatile TR-FRET kinase binding assay platform by Lebakken, Connie S., Koepnick, Elizabeth, Bruinsma, Rica, Riddle, Steve

“…Abstract There is great potential for the utilization of selective kinase inhibitors in the treatment of many clinical indications, especially in oncology and…”
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Pharmacological characterization of purified recombinant mTOR FRB-kinase domain using fluorescence-based assays by Reichling, Laurie J, Lebakken, Connie S, Riddle, Steven M, Vedvik, Kevin L, Robers, Matthew B, Kopp, Leisha M, Bruinsma, Rica, Vogel, Kurt W

“…The mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in nutrient sensing and cell growth and is a validated target for oncology and…”
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Fluorescent cascade and direct assays for characterization of RAF signaling pathway inhibitors by Kupcho, Kevin R, Bruinsma, Rica, Hallis, Tina M, Lasky, David A, Somberg, Richard L, Turek-Etienne, Tammy, Vogel, Kurt W, Huwiler, Kristin G

“…RAF kinases are part of a conserved signaling pathway that impacts cell growth, differentiation, and survival, and RAF pathway dysregulation is an attractive…”
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Fluorescent Cascade and Direct Assays for Characterization of RAF Signaling Pathway Inhibitors by Kupcho, Kevin R, Bruinsma, Rica, Hallis, Tina M, Lasky, David A, Somberg, Richard L, Turek-Etienne, Tammy, Vogel, Kurt W, Huwiler, Kristin G

“…RAF kinases are part of a conserved signaling pathway that impacts cell growth, differentiation, and survival, and RAF pathway dysregulation is an attractive…”
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Homogenous Fluorescent Assays for Characterizing Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK) by Reichling, Laurie J, Riddle, Steven M, Mei, Baigen, Bruinsma, Rica, Goossens, Tony A, Huwiler, Kristin G, Maffitt, Mark, Newport, Alyssa MG, Qian, Xiao-Dong, Ruttimann-Johnson, Carmen, Vogel, Kurt W

“…AMP activated protein kinase (AMPK) is a key regulator of cellular metabolism. AMPK activity is modulated in part by binding of AMP to the -subunit of the…”
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Homogenous fluorescent assays for characterizing small-molecule activators of AMP-activated protein kinase (AMPK) by Reichling, Laurie J, Riddle, Steven M, Mei, Baigen, Bruinsma, Rica, Goossens, Tony A, Huwiler, Kristin G, Maffitt, Mark, Newport, Alyssa M G, Qian, Xiao-Dong, Ruttimann-Johnson, Carmen, Vogel, Kurt W

“…AMP activated protein kinase (AMPK) is a key regulator of cellular metabolism. AMPK activity is modulated in part by binding of AMP to the gamma-subunit of the…”
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