Search Results - "Bruins, L."

Signal transduction and functional selectivity of F15599, a preferential post‐synaptic 5‐HT1A receptor agonist by Newman‐Tancredi, A, Martel, J‐C, Assié, M‐B, Buritova, J, Lauressergues, E, Cosi, C, Heusler, P, Bruins Slot, L, Colpaert, FC, Vacher, B, Cussac, D

“…Background and purpose:  Activation of post‐synaptic 5‐HT1A receptors may provide enhanced therapy against depression. We describe the signal transduction…”
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Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M3P) by Kortüm, K. M., Langer, C., Monge, J., Bruins, L., Zhu, Y. X., Shi, C. X., Jedlowski, P., Egan, J. B., Ojha, J., Bullinger, L., Kull, M., Ahmann, G., Rasche, L., Knop, S, Fonseca, R., Einsele, H., Stewart, A. K., Braggio, Esteban

“…Recent advances in genomic sequencing technologies now allow results from deep next-generation sequencing to be obtained within clinically meaningful…”
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Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients by Kortuem, K M, Braggio, E, Bruins, L, Barrio, S, Shi, C S, Zhu, Y X, Tibes, R, Viswanatha, D, Votruba, P, Ahmann, G, Fonseca, R, Jedlowski, P, Schlam, I, Kumar, S, Bergsagel, P L, Stewart, A K

“…We employed a customized Multiple Myeloma (MM)-specific Mutation Panel (M 3 P) to screen a homogenous cohort of 142 untreated MM patients for relevant…”
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F15063, a compound with D 2 /D 3 antagonist, 5‐HT 1A agonist and D 4 partial agonist properties: (III) Activity in models of cognition and negative symptoms by Depoortère, R, Auclair, A L, Bardin, L, Slot, L Bruins, Kleven, M S, Colpaert, F, Vacher, B, Newman‐Tancredi, A

“…Background and purpose: The D 2 /D 3 receptor antagonist, D 4 receptor partial agonist, and high efficacy 5‐HT 1A receptor agonist F15063 was shown to be…”
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F15063, a potential antipsychotic with D 2 /D 3 antagonist, 5‐HT 1A agonist and D 4 partial agonist properties: (I) in vitro receptor affinity and efficacy profile by Newman‐Tancredi, A, Assié, M‐B, Martel, J‐C, Cosi, C, Slot, L Bruins, Palmier, C, Rauly‐Lestienne, I, Colpaert, F, Vacher, B, Cussac, D

“…Background and purpose: Combining 5‐HT 1A receptor activation with dopamine D 2 /D 3 receptor blockade should improve negative symptoms and cognitive deficits…”
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Study of the addictive potential of modafinil in naive and cocaine-experienced rats by DEROCHE-GAMONET, V, DARNAUDERY, M, BRUINS-SLOT, L, PIAT, F, LE MOAL, M, PIAZZA, P. V

“…Modafinil is a drug that promotes wakefulness and, as such, is used to treat hypersomnia and narcolepsy. Preclinical and clinical studies suggest that…”
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Identification of FAM46C as a tumor suppressor in Multiple Myeloma by Zhu, Y.X, Shi, C.X, Jedlowski, P, Kortüm, K.M, Bruins, L, Braggio, E, Wang, X, Stewart, A.K

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Opiate self-administration as a measure of chronic nociceptive pain in arthritic rats by Colpaert, F.C, Tarayre, J.P, Alliaga, M, Bruins Slot, L.A, Attal, N, Koek, W

“…The study examined the validity of oral fentanyl self-administration (FSA) as a measure of the chronic nociceptive pain that develops in rats with adjuvant…”
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Opiate States of Memory: Receptor Mechanisms by Slot, L. A. Bruins, Colpaert, F. C

“…The present studies characterized the receptor mechanisms of morphine-induced states of memory. Morphine (5 mg/kg) produced a state in which rats could learn…”
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Targeted sequencing of relapsed/refractory myeloma patients identifies an enrichment of mutations in MAPK and Cereblon pathways by Kortüm, K.M, Mai, E.K, Hanafiah, N.H, Barrio, S, Bruins, L, Merz, M, Xu, J, Pashayeva, K, Zhu, Y.X, Shi, C.X, Jedlowski, P, Ahmann, G, Andrulis, M, Hillengass, J, Goldschmidt, H, Fonseca, R, Bergsagel, P.L, Braggio, E, Raab, M.S, Stewart, A.K

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F15063, a compound with D2/D3 antagonist, 5‐HT1A agonist and D4 partial agonist properties: (III) Activity in models of cognition and negative symptoms by Depoortère, R, Auclair, A L, Bardin, L, Slot, L Bruins, Kleven, M S, Colpaert, F, Vacher, B, Newman‐Tancredi, A

“…Background and purpose: The D2/D3 receptor antagonist, D4 receptor partial agonist, and high efficacy 5‐HT1A receptor agonist F15063 was shown to be highly…”
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Rice Cultivation and the Struggle for Subsistence in Early Colonial Suriname (1668-1702) by Elfrink, Thijs L, van de Hoef, Marden J.J, van Montfort, Jip, Bruins, Anna L, van Andel, Tinde

“…Abstract The Black Rice Debate discusses the agency of enslaved Africans in rice cultivation in the Americas from the seventeenth century onward. With regard…”
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F15063, a potential antipsychotic with D2/D3 antagonist, 5‐HT1A agonist and D4 partial agonist properties: (I) in vitro receptor affinity and efficacy profile by Newman‐Tancredi, A, Assié, M‐B, Martel, J‐C, Cosi, C, Slot, L Bruins, Palmier, C, Rauly‐Lestienne, I, Colpaert, F, Vacher, B, Cussac, D

“…Background and purpose: Combining 5‐HT1A receptor activation with dopamine D2/D3 receptor blockade should improve negative symptoms and cognitive deficits in…”
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Signal transduction and functional selectivity of F15599, a preferential post‐synaptic 5‐HT 1A receptor agonist by Newman‐Tancredi, A, Martel, J‐C, Assié, M‐B, Buritova, J, Lauressergues, E, Cosi, C, Heusler, P, Bruins Slot, L, Colpaert, FC, Vacher, B, Cussac, D

“…Background and purpose:  Activation of post‐synaptic 5‐HT 1A receptors may provide enhanced therapy against depression. We describe the signal transduction…”
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Recall Rendered Dependent on an Opiate State by Slot, L. A. Bruins, Colpaert, F. C

“…Remembering may require that the organism be in a state that is similar to that in which the event was initially experienced (state dependence [StD]). We…”
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Lack of Association between Anorexia Nervosa and D3 Dopamine Receptor Gene by Bruins-Slot, Lisbeth, Gorwood, Philip, Bouvard, Manuel, Blot, Phillipe, Adès, Jean, Feingold, Josué, Schwartz, Jean-Charles, Mouren-Siméoni, Marie-Christine

“…Background: Evidence from family and twin studies suggests a genetic contribution to the etiology of anorexia nervosa. Different genes could contribute to the…”
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Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats by Bruins Slot, L.A, Tarayre, J.-P, Koek, W, Ribet, J.-P, Colpaert, F.C

“…For the analysis of pharmacotherapeutic regimens for chronic pain in animals, it is important to establish delivery methods in which analgesics can be…”
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Neuroactive steroids and the constraint of memory by Slot, L. A. Bruins, Piazza, P. V., Colpaert, F. C.

“…Different normo‐ and pathophysiological conditions are associated with large variations in plasma and brain concentrations of neuroactive steroids. In an…”
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Sign-reversal during Persistent Activation in μ -Opioid Signal Transduction by BRUINS SLOT, L.A., PAUWELS, P.J., COLPAERT, F.C.

“…A concept of signal transduction in biological systems specifies that any instantaneous input is appreciated by its departure from the moving average of past…”
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The AVOCAT study: Bicalutamide monotherapy versus combined bicalutamide plus dutasteride therapy for patients with locally advanced or metastatic carcinoma of the prostate—a long-term follow-up comparison and quality of life analysis by Dijkstra, Siebren, Witjes, Wim P. J., Roos, Erik P. M., Vijverberg, Peter L. M., Geboers, Arno D. H., Bruins, Jos L., Smits, Geert A. H. J., Vergunst, Henk, Mulders, Peter F. A.

“…Purpose Compare the efficacy and tolerability of dutasteride in combination with bicalutamide to bicalutamide monotherapy in the treatment of locally advanced…”
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