Search Results - "Bruijnzeel, Piet"

Targeting neutrophilic inflammation in severe neutrophilic asthma: can we target the disease‐relevant neutrophil phenotype? by Bruijnzeel, Piet L. B., Uddin, Mohib, Koenderman, Leo

“…Review of how distinct neutrophil phenotypes at the site of inflammation necessitate more specific future anti‐neutrophil therapy. In severe, neutrophilic…”
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Clusters of Comorbidities Based on Validated Objective Measurements and Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease by VANFLETEREN, Lowie E. G. W, SPRUIT, Martijn A, GROENEN, Miriam, GAFFRON, Swetlana, VAN EMPEL, Vanessa P. M, BRUIJNZEEL, Piet L. B, RUTTEN, Erica P. A, ROODT, Jos Op 't, WOUTERS, Emiel F. M, FRANSSEN, Frits M. E

“…Comorbidities contribute to disease severity and mortality in patients with chronic obstructive pulmonary disease (COPD). Comorbidities have been studied…”
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Prevalence of metabolic syndrome in COPD patients and its consequences by Breyer, Marie-Kathrin, Spruit, Martijn A, Hanson, Corrine K, Franssen, Frits M E, Vanfleteren, Lowie E G W, Groenen, Miriam T J, Bruijnzeel, Piet L B, Wouters, Emiel F M, Rutten, Erica P A

“…The prevalence of metabolic syndrome in COPD patients and its impact on patient related outcomes has been little studied. We evaluated the prevalence of…”
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Arterial stiffness in patients with COPD: the role of systemic inflammation and the effects of pulmonary rehabilitation by VANFLETEREN, Lowie E. G. W, SPRUIT, Martijn A, GROENEN, Miriam T. J, BRUIJNZEEL, Piet L. B, TAIB, Ziad, RUTTEN, Erica P. A, OP 'T ROODT, Jos, AKKERMANS, Marco A, WOUTERS, Emiel F. M, FRANSSEN, Frits M. E

“…Clear evidence for an association between systemic inflammation and increased arterial stiffness in patients with chronic obstructive pulmonary disease (COPD)…”
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Objectively identified comorbidities in COPD: impact on pulmonary rehabilitation outcomes by Mesquita, Rafael, Vanfleteren, Lowie E G W, Franssen, Frits M E, Sarv, Janeli, Taib, Ziad, Groenen, Miriam T J, Gaffron, Swetlana, Bruijnzeel, Piet L B, Pitta, Fabio, Wouters, Emiel F M, Spruit, Martijn A

“…Pulmonary rehabilitation (PR) is a comprehensive intervention recognised as a core component in the treatment of patients with chronic obstructive pulmonary…”
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Phenotypic Characteristics Associated With Reduced Short Physical Performance Battery Score in COPD by Patel, Mehul S., MBBS, Mohan, Divya, MBBS, Andersson, Yvonne M., BSc, Baz, Manuel, MD, Samantha Kon, S.C., MBBS, Canavan, Jane L., PhD, Jackson, Sonya G., PhD, Clark, Amy L., BSc, Hopkinson, Nicholas S., PhD, Natanek, Samantha A., PhD, Kemp, Paul R., PhD, Bruijnzeel, Piet L.B., PhD, Man, William D.-C., PhD, Polkey, Michael I., PhD

“…Background The Short Physical Performance Battery (SPPB) is commonly used in gerontology, but its determinants have not been previously evaluated in COPD. In…”
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The pathogenesis of photoaging: the role of neutrophils and neutrophil-derived enzymes by Rijken, Feiko, Bruijnzeel, Piet L B

“…The hallmark of photoaged skin is solar elastosis, which is probably an end product of elastic fiber degradation. Exposure of human skin to a certain threshold…”
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Lower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease by Suzuki, Masaru, Makita, Hironi, Östling, Jörgen, Thomsen, Laura H, Konno, Satoshi, Nagai, Katsura, Shimizu, Kaoruko, Pedersen, Jesper H, Ashraf, Haseem, Bruijnzeel, Piet L B, Maciewicz, Rose A, Nishimura, Masaharu

“…The rate of annual change in FEV1 is highly variable among patients with chronic obstructive pulmonary disease (COPD). Reliable blood biomarkers are needed to…”
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Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition by Keir, Holly R, Fong, Christopher J, Crichton, Megan L, Barth, Philip, Chevalier, Eric, Brady, Gill, Kennedy, Gwen, Zimmermann, Johann, Bruijnzeel, Piet L B, Dicker, Alison J, Chalmers, James D

“…Neutrophil elastase (NE) has been linked to lung neutrophil dysfunction in bronchiectasis and cystic fibrosis (CF), making NE inhibition a potential…”
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Feasibility assessment of using oxygen-enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in COPD by Morgan, Alexandra R, Parker, Geoff J.M, Roberts, Caleb, Buonaccorsi, Giovanni A, Maguire, Niall C, Hubbard Cristinacce, Penny L, Singh, Dave, Vestbo, Jørgen, Bjermer, Leif, Jögi, Jonas, Taib, Ziad, Sarv, Janeli, Bruijnzeel, Piet L.B, Olsson, Lars E, Bondesson, Eva, Nihlén, Ulf, McGrath, Deirdre M, Young, Simon S, Waterton, John C, Nordenmark, Lars H

“…Highlights • We investigate physiologic response to standard COPD treatment regimes using OE-MRI. • We assess the potential role of OE-MRI in future drug…”
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Neutrophil Infiltration in Normal Human Skin After Exposure to Different Ultraviolet Radiation Sources by Lee, Peter L., Van Weelden, Huib, Bruijnzeel, Piet L. B.

“…Exposure of the skin to UV radiation can lead to a local infiltration of neutrophils. Not much is known on whether the infiltration of neutrophils in the…”
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Phenotypes of symptomatic airways disease in China and New Zealand by Fingleton, James, Huang, Kewu, Weatherall, Mark, Guo, Yanfei, Ivanov, Stefan, Bruijnzeel, Piet, Zhang, Hong, Wang, Wei, Beasley, Richard, Wang, Chen

“…It is uncertain whether phenotypes of asthma and chronic obstructive pulmonary disease (COPD) vary between populations with different genetic and environmental…”
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The protective effect of sunscreens, vitamin E 6% cream, and betamethasone 0.1% cream on solar-simulating radiation-induced erythema and neutrophil influx by Rijken, Feiko, MD, PhD, Bihari, Ilse C., BSc, Guikers, Kees L.H., BSc, van Weelden, Huib, MSc, Bruijnzeel, Piet L.B., MD, PhD

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Responses of Black and White Skin to Solar-Simulating Radiation: Differences in DNA Photodamage, Infiltrating Neutrophils, Proteolytic Enzymes Induced, Keratinocyte Activation, and IL-10 Expression by Rijken, Feiko, Bruijnzeel, Piet L.B., van Weelden, Huib, Kiekens, Rebecca C.M.

“…Black skin is more resistant to the deleterious effects of ultraviolet radiation than white skin. A higher melanin content and a different melanosomal…”
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Pathophysiology of photoaging of human skin: focus on neutrophils by Rijken, Feiko, Kiekens, Rebecca C M, van den Worm, Edwin, Lee, Peter L, van Weelden, Huib, Bruijnzeel, Piet L B

“…UV-induced skin damage is the result of a complex cascade of events. Many studies have focused on the skin effects induced by UV-B or UV-A separately. Recently…”
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Study on risk factors and phenotypes of acute exacerbations of chronic obstructive pulmonary disease in Guangzhou, China-design and baseline characteristics by Zhou, Yumin, Bruijnzeel, Piet L B, McCrae, Christopher, Zheng, Jinping, Nihlen, Ulf, Zhou, Rong, Van Geest, Marleen, Nilsson, Anna, Hadzovic, Sinela, Huhn, Monika, Taib, Ziad, Gu, Yi, Xie, Jiaxing, Ran, Pixin, Chen, Rongchang, Zhong, Nanshan

“…To describe a study design that focuses on risk factors and patterns of chronic obstructive pulmonary disease (COPD) exacerbations. A 2-year, single centre,…”
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Pharmacological effects of oximes : how relevant are they ? by VAN HELDEN, H. P. M, BUSKER, R. W, MELCHERS, B. P. C, BRUIJNZEEL, P. L. B

“…The increased international concern about the threat of military and terroristic use of nerve agents, prompted us to critically consider the expected value of…”
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Human Eosinophils Constitutively Express a Functional Interleukin-4 Receptor: Interleukin-4 -Induced Priming of Chemotactic Responses and Induction of PI-3 Kinase Activity by Dubois, Gerald R, Schweizer, Rene C, Versluis, Coraline, Bruijnzeel-Koomen, Carla A. F. M, Bruijnzeel, Piet L. B

“…Similar to interleukin-3 (IL-3), IL-5, and granulocyte macrophage colony-stimulating factor (GM-CSF), IL-4 can be secreted by several cell types involved in…”
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Modulation of the atopy patch test reaction by topical corticosteroids and tar by Langeveld-Wildschut, Elisabeth G., Riedl, Hannes, Thepen, Theo, Biharia, Ilse C., Bruijnzeel, Piet L.B., Bruijnzeel-Koomen, Carla A.F.M.

“…Background: Pharmacologic studies in atopic eczema (AE) are difficult to standardize. Patients with AE differ in the stage of their skin disease (acute,…”
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Scopolamine Augments the Efficacy of Physostigmine Against Soman Poisoning in Guinea Pigs by Philippens, Ingrid H.C.H.M, Melchers, Bert P.C, Olivier, Berend, Bruijnzeel, Piet L.B

“…The efficacy of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic receptor…”
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