Search Results - "Bruijn, Diederik de"

Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma by Lubieniecka, Joanna M, de Bruijn, Diederik R H, Su, Le, van Dijk, Anke H A, Subramanian, Subbaya, van de Rijn, Matt, Poulin, Neal, van Kessel, Ad Geurts, Nielsen, Torsten O

“…Synovial sarcoma is a soft tissue malignancy characterized by the fusion of SS18 to either SSX1, SSX2, or SSX4 genes. SS18 and SSX are transcriptional…”
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The synovial sarcoma : Associated SS18-SSX2 fusion protein induces epigenetic gene (De)regulation by DE BRUIJN, Diederik R. H, ALLANDER, Susanne V, VAN DIJK, Anke H. A, WILLEMSE, Marieke P, THIJSSEN, Jose, VAN GRONINGEN, Jan J. M, MELTZER, Paul S, VAN KESSEL, Ad Geurts

“…Fusion of the SS18 and either one of the SSX genes is a hallmark of human synovial sarcoma. The SS18 and SSX genes encode nuclear proteins that exhibit…”
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Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice by Balemans, Monique C.M., Ansar, Muhammad, Oudakker, Astrid R., van Caam, Arjan P.M., Bakker, Brenda, Vitters, Elly L., van der Kraan, Peter M., de Bruijn, Diederik R.H., Janssen, Sanne M., Kuipers, Arthur J., Huibers, Manon M.H., Maliepaard, Eliza M., Walboomers, X. Frank, Benevento, Marco, Nadif Kasri, Nael, Kleefstra, Tjitske, Zhou, Huiqing, Van der Zee, Catharina E.E.M., van Bokhoven, Hans

“…Haploinsufficiency of Euchromatin histone methyltransferase 1 (EHMT1), a chromatin modifying enzyme, is the cause of Kleefstra syndrome (KS). KS is an…”
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Next generation sequencing in synovial sarcoma reveals novel gene mutations by Vlenterie, Myrella, Hillebrandt-Roeffen, Melissa H S, Flucke, Uta E, Groenen, Patricia J T A, Tops, Bastiaan B J, Kamping, Eveline J, Pfundt, Rolph, de Bruijn, Diederik R H, Geurts van Kessel, Ad H M, van Krieken, Han J H J M, van der Graaf, Winette T A, Versleijen-Jonkers, Yvonne M H

“…Over 95% of all synovial sarcomas (SS) share a unique translocation, t(X;18), however, they show heterogeneous clinical behavior. We analyzed multiple SS to…”
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The mitotic arrest deficient protein MAD2B interacts with the clathrin light chain A during mitosis by Medendorp, Klaas, Vreede, Lilian, van Groningen, Jan J M, Hetterschijt, Lisette, Brugmans, Linda, Jansen, Patrick A M, van den Hurk, Wilhelmina H, de Bruijn, Diederik R H, van Kessel, Ad Geurts

“…Although the mitotic arrest deficient protein MAD2B (MAD2L2) is thought to inhibit the anaphase promoting complex (APC) by binding to CDC20 and/or CDH1 (FZR1),…”
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Germline Epigenetic Silencing of the Tumor Suppressor Gene PTPRJ in Early-Onset Familial Colorectal Cancer by Venkatachalam, Ramprasath, Ligtenberg, Marjolijn J.L, Hoogerbrugge, Nicoline, Schackert, Hans K, Görgens, Heike, Hahn, Marc-Manuel, Kamping, Eveline J, Vreede, Lilian, Hoenselaar, Eveline, van der Looij, Erica, Goossens, Monique, Churchman, Mike, Carvajal-Carmona, Luis, Tomlinson, Ian P.M, de Bruijn, Diederik R.H, Van Kessel, Ad Geurts, Kuiper, Roland P

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Research in Action—Students’ Perspectives on the Integration of Research Activities in Undergraduate Biomedical Curricula by de Vegt, Femmie, Otten, Johannes D. M., de Bruijn, Diederik R. H., Pluk, Helma, van Rooij, Iris A. L. M., Oostendorp, Thom F.

“…We describe and evaluate our practice-based learning approach for research in undergraduate students studying Biomedical Sciences at Radboud University…”
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The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle by Medendorp, Klaas, van Groningen, Jan J M, Vreede, Lilian, Hetterschijt, Lisette, van den Hurk, Wilhelmina H, de Bruijn, Diederik R H, Brugmans, Linda, van Kessel, Ad Geurts

“…Previously, we identified the mitotic arrest deficient protein MAD2B (MAD2L2) as a bona fide interactor of the renal cell carcinoma (RCC)-associated protein…”
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The (Epi)genetics of human synovial sarcoma by de Bruijn, Diederik R. H., Nap, Jan-Peter, van Kessel, Ad Geurts

“…Human synovial sarcomas are aggressive soft tissue tumors with relatively high rates of recurrences and metastases. They display a variable response to common…”
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The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex by Debernardi, Silvana, Bassini, Alessandra, Jones, Louise K., Chaplin, Tracy, Linder, Britta, de Bruijn, Diederik R.H., Meese, Eckart, Young, Bryan D.

“…The AF10 gene encodes a putative transcription factor containing an N-terminal LAP/PHD zinc finger motif, a functional nuclear localization signal, an AT-hook…”
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Differential presentation of tumor antigen‐derived epitopes by MHC‐class I and antigen‐positive tumor cells by Held, Gerhard, Neumann, Frank, Sturm, Christine, Kaestner, Lars, Dauth, Nina, de Bruijn, Diederik, R., Renner, Christoph, Lipp, Peter, Pfreundschuh, Michael

“…SSX2 is a member of the family of cancer/testis antigens. The SSX2 derived peptide SSX2103–111 has been shown to be presented to cytotoxic T‐lymphocytes (CTL)…”
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SYT Associates with Human SNF/SWI Complexes and the C-terminal Region of Its Fusion Partner SSX1 Targets Histones by Kato, Hiroyuki, Tjernberg, Agneta, Zhang, Wenzhu, Krutchinsky, Andrew N, An, Woojin, Takeuchi, Tamotsu, Ohtsuki, Yuji, Sugano, Sumio, de Bruijn, Diederik R, Chait, Brian T, Roeder, Robert G

“…A global transcriptional co-activator, the SNF/SWI complex, has been characterized as a chromatin remodeling factor that enhances accessibility of the…”
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Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic by Gunster, Marco J., Satijn, David P., Hamer, Karien M., Blaauwen, Jan L. den, Bruijn, Diederik de, Alkema, Mark J., Lohuizen, Maarten van, Driel, Roel van, Otte, Arie P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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SSX cancer testis antigens are expressed in most multiple myeloma patients : Co-expression of SSX1, 2, 4, and 5 correlates with adverse prognosis and high frequencies of SSX-positive PCs by TAYLOR, Brian J, REIMAN, Tony, PITTMAN, Julie A, KEATS, Jonathan J, DE BRUIJN, Diederik R. H, MANT, Michael J, BELCH, Andrew R, PILARSKI, Linda M

“…Cancer testis antigens (CTAs) are tumor-specific antigens that may be useful targets for cancer vaccines. Here, CTA expression was examined in multiple myeloma…”
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The epigenetics of (hereditary) colorectal cancer by Venkatachalam, Ramprasath, Ligtenberg, Marjolijn J.L, Hoogerbrugge, Nicoline, de Bruijn, Diederik R.H, Kuiper, Roland P, Geurts van Kessel, Ad

“…Abstract In the last decade, it has become apparent that not only DNA sequence variations but also epigenetic modifications may contribute to disease,…”
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Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines by DOS SANTOS, N. R, TORENSMA, R, DE VRIES, T. J, SCHREURS, M. W. J, DE BRUIJN, D. R. H, KATER-BAATS, E, RUITER, D. J, ADEMA, G. J, VAN MUIJEN, G. N. P, VAN KESSEL, A. G

“…The SSX genes, located on the X chromosome, encode a family of highly homologous nuclear proteins. The SSX1 and SSX2 genes were initially identified as fusion…”
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The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP by de Bruijn, Diederik R.H., dos Santos, Nuno R., Kater-Baats, Ellen, Thijssen, José, van den Berk, Lieke, Stap, Jiska, Balemans, Matthé, Schepens, Marga, Merkx, Gerard, Geurts van Kessel, Ad

“…The SSX gene family is composed of at least five functional and highly homologous members, SSX1 to SSX5, that are normally expressed in only the testis and…”
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Nuclear Localization of SYT, SSX and the Synovial Sarcoma-Associated SYT-SSX Fusion Proteins by dos Santos, Nuno R., de Bruijn, Diederik R. H., Balemans, Matthé, Janssen, Bert, Gärtner, Fátima, Lopes, José Manuel, de Leeuw, Bertie, Geurts van Kessel, Ad

“…Synovial sarcoma is characterized by a prevalent chromosomal translocation, t(X;18)(p11;q11). As a result of this translocation the SYT gene on chromosome 18…”
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Human synovial sarcoma: towards novel therapeutic strategies by de Bruijn, Diederik R.H, van Dijk, Anke H.A, Flucke, Uta, Geurts van Kessel, Ad

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Germline epimutation of the tumor suppressor gene PTPRJ in early onset familial colorectal cancer by Venkatachalam, Ramprasath, Ligtenberg, Marjolijn J.L, Hoogerbrugge, Nicoline, Schackert, Hans K, Carvajal-Carmona, Luis, Kamping, Eveline J, Vreede, Lilian, Hoenselaar, Eveline, Goossens, Monique, van der Looij, Erica, Churchman, Mike, Görgens, Heike, Tomlinson, Ian P.M, de Bruijn, Diederik R.H, Geurts van Kessel, Ad, Kuiper, Roland P

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