Search Results - "Bruhn, Jessica F."

Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation by Wang, Bo, Bruhn, Jessica F, Weldeab, Asmerom, Wilson, Timothy S, McGilvray, Philip T, Mashore, Michael, Song, Qiong, Scapin, Giovanna, Lin, Yiqing

“…Microcrystal electron diffraction (MicroED) has established its complementary role alongside X-ray diffraction in crystal structure elucidation. Unfortunately,…”
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Crystal Structure of the Marburg Virus VP35 Oligomerization Domain by Bruhn, Jessica F, Kirchdoerfer, Robert N, Urata, Sarah M, Li, Sheng, Tickle, Ian J, Bricogne, Gérard, Saphire, Erica Ollmann

“…Marburg virus (MARV) is a highly pathogenic filovirus that is classified in a genus distinct from that of Ebola virus (EBOV) (genera Marburgvirus and…”
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A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function by Bruhn, Jessica F., Hotard, Anne L., Spiropoulou, Christina F., Lo, Michael K., Saphire, Erica Ollmann

“…Nipah virus is a highly lethal zoonotic pathogen found in Southeast Asia that has caused human encephalitis outbreaks with 40%–70% mortality. NiV encodes its…”
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Crystal Structure of the Nipah Virus Phosphoprotein Tetramerization Domain by Bruhn, Jessica F, Barnett, Katherine C, Bibby, Jaclyn, Thomas, Jens M H, Keegan, Ronan M, Rigden, Daniel J, Bornholdt, Zachary A, Saphire, Erica Ollmann

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop by Murin, Charles D., Bruhn, Jessica F., Bornholdt, Zachary A., Copps, Jeffrey, Stanfield, Robyn, Ward, Andrew B.

“…Monoclonal antibodies (mAbs) with pan-ebolavirus cross-reactivity are highly desirable, but development of such mAbs is limited by a lack of a molecular…”
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Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies by Murin, Charles D., Gilchuk, Pavlo, Ilinykh, Philipp A., Huang, Kai, Kuzmina, Natalia, Shen, Xiaoli, Bruhn, Jessica F., Bryan, Aubrey L., Davidson, Edgar, Doranz, Benjamin J., Williamson, Lauren E., Copps, Jeffrey, Alkutkar, Tanwee, Flyak, Andrew I., Bukreyev, Alexander, Crowe, James E., Ward, Andrew B.

“…Antibodies that target the glycan cap epitope on the ebolavirus glycoprotein (GP) are common in the adaptive response of survivors. A subset is known to be…”
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Small Molecule Microcrystal Electron Diffraction for the Pharmaceutical Industry-Lessons Learned From Examining Over Fifty Samples by Bruhn, Jessica F, Scapin, Giovanna, Cheng, Anchi, Mercado, Brandon Q, Waterman, David G, Ganesh, Thejusvi, Dallakyan, Sargis, Read, Brandon N, Nieusma, Travis, Lucier, Kyle W, Mayer, Megan L, Chiang, Nicole J, Poweleit, Nicole, McGilvray, Philip T, Wilson, Timothy S, Mashore, Michael, Hennessy, Camille, Thomson, Sean, Wang, Bo, Potter, Clinton S, Carragher, Bridget

“…The emerging field of microcrystal electron diffraction (MicroED) is of great interest to industrial researchers working in the drug discovery and drug…”
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Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope by Correia, Bruno E., Ban, Yih-En Andrew, Holmes, Margaret A., Xu, Hengyu, Ellingson, Katharine, Kraft, Zane, Carrico, Chris, Boni, Erica, Sather, D. Noah, Zenobia, Camille, Burke, Katherine Y., Bradley-Hewitt, Tyler, Bruhn-Johannsen, Jessica F., Kalyuzhniy, Oleksandr, Baker, David, Strong, Roland K., Stamatatos, Leonidas, Schief, William R.

“…Broadly cross-reactive monoclonal antibodies define epitopes for vaccine development against HIV and other highly mutable viruses. Crystal structures are…”
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Leginon: New features and applications by Cheng, Anchi, Negro, Carl, Bruhn, Jessica F., Rice, William J., Dallakyan, Sargis, Eng, Edward T., Waterman, David G., Potter, Clinton S., Carragher, Bridget

“…Leginon is a system for automated data acquisition from a transmission electron microscope. Here we provide an updated summary of the overall Leginon…”
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Computational Protein Design Using Flexible Backbone Remodeling and Resurfacing: Case Studies in Structure-Based Antigen Design by Correia, Bruno E., Ban, Yih-En Andrew, Friend, Della J., Ellingson, Katharine, Xu, Hengyu, Boni, Erica, Bradley-Hewitt, Tyler, Bruhn-Johannsen, Jessica F., Stamatatos, Leonidas, Strong, Roland K., Schief, William R.

“…Computational protein design has promise for vaccine design and other applications. We previously transplanted the HIV 4E10 epitope onto non-HIV protein…”
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Absolute Configuration Determination of Chiral API Molecules by MicroED Analysis of Cocrystal Powders Formed Based on Cocrystal Propensity Prediction Calculations by Shah, Harsh S., Yuan, Jiuchuang, Xie, Tian, Yang, Zhuocen, Chang, Chao, Greenwell, Chandler, Zeng, Qun, Sun, GuangXu, Read, Brandon N., Wilson, Timothy S., Valle, Henry U., Kuang, Shanming, Wang, Jian, Sekharan, Sivakumar, Bruhn, Jessica F.

“…Establishing the absolute configuration of chiral active pharmaceutical ingredients (APIs) is of great importance. Single crystal X‐ray diffraction (scXRD) has…”
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Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation by Harrison, Jerry Joe E K, Passos, Dario Oliveira, Bruhn, Jessica F, Bauman, Joseph D, Tuberty, Lynda, DeStefano, Jeffrey J, Ruiz, Francesc Xavier, Lyumkis, Dmitry, Arnold, Eddy

“…Key proteins of retroviruses and other RNA viruses are translated and subsequently processed from polyprotein precursors by the viral protease (PR). Processing…”
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High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus by Clifton, Matthew C., Bruhn, Jessica F., Atkins, Kateri, Webb, Terry L., Baydo, Ruth O., Raymond, Amy, Lorimer, Donald D., Edwards, Thomas E., Myler, Peter J., Saphire, Erica Ollmann

“…Ebolaviruses cause severe hemorrhagic fever. Central to the Ebola life cycle is the matrix protein VP40, which oligomerizes and drives viral budding. Here we…”
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A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function by Bruhn, Jessica F., Hotard, Anne L., Spiropoulou, Christina F., Lo, Michael K., Saphire, Erica Ollmann

“…Nipah virus is a highly lethal zoonotic pathogen found in Southeast Asia that has caused human encephalitis outbreaks with 40%–70% mortality. NiV encodes its…”
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High-resolution Crystal Structure of Dimeric VP[subscript 40] From Sudan ebolavirus by Clifton, Matthew C., Bruhn, Jessica F., Atkins, Kateri, Webb, Terry L., Baydo, Ruth O., Raymond, Amy, Lorimer, Donald D., Edwards, Thomas E., Myler, Peter J., Saphire, Erica Ollmann

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