Search Results - "Bruhn, Alejandro"

Reply letter on “Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study” by Basoalto, Roque, Bruhn, Alejandro

Get full text

Electrical impedance tomography in acute respiratory distress syndrome by Bachmann, M Consuelo, Morais, Caio, Bugedo, Guillermo, Bruhn, Alejandro, Morales, Arturo, Borges, João B, Costa, Eduardo, Retamal, Jaime

“…Acute respiratory distress syndrome (ARDS) is a clinical entity that acutely affects the lung parenchyma, and is characterized by diffuse alveolar damage and…”
Get full text

Effects of Prone Positioning on Lung Protection in Patients with Acute Respiratory Distress Syndrome by CORNEJO, Rodrigo A, DIAZ, Juan C, ARELLANO, Daniel H, NEIRA, Wilson R, DIAZ, Gonzalo A, ZAMORANO, Aníbal J, PEREIRA, Gonzalo L, TOBAR, Eduardo A, BRUHN, Alejandro R, RAMOS, Cristobal A, GONZALEZ, Roberto A, REPETTO, Claudia A, ROMERO, Carlos M, GALVEZ, Luis R, LLANOS, Osvaldo

“…Positive end-expiratory pressure (PEEP) and prone positioning may induce lung recruitment and affect alveolar dynamics in acute respiratory distress syndrome…”
Get full text

Impact of Reverse Triggering Dyssynchrony during Lung-Protective Ventilation on Diaphragm Function: An Experimental Model by Damiani, L Felipe, Engelberts, Doreen, Bastia, Luca, Osada, Kohei, Katira, Bhushan H, Otulakowski, Gail, Goligher, Ewan C, Reid, W Darlene, Dubo, Sebastián, Bruhn, Alejandro, Post, Martin, Kavanagh, Brian P, Brochard, Laurent J

“…Reverse triggering dyssynchrony (RT) is a patient-ventilator interaction where a respiratory muscle contraction is triggered by a passive mechanical…”
Get full text

Infection with SARS-CoV-2 variant Gamma (P.1) in Chile increased ICU admission risk three to five-fold by Sauré, Denis, Neira, Ignasi, Goic, Marcel, O'Ryan, Miguel, Torres, Juan P, Bruhn, Alejandro, Ferres, Marcela, Angulo, Jenniffer, Vera, Magdalena, Basso, Leonardo J

“…The 2021 wave of SARS-CoV-2 infection in Chile was characterized by an explosive increase in ICU admissions, which disproportionately affected individuals…”
Get full text

Driving pressure: a marker of severity, a safety limit, or a goal for mechanical ventilation? by Bugedo, Guillermo, Retamal, Jaime, Bruhn, Alejandro

“…After the description of the baby lung concept [10], which revealed a physiologically small lungs in patients with ARDS, several studies in the 1990s tested…”
Get full text

Microcirculation in sepsis: new perspectives by Hernandez, Glenn, Bruhn, Alejandro, Ince, Can

“…Microcirculatory dysfunction has been recently recognized as a key pathophysiologic process in the evolution of sepsis. In the present review, we discuss…”
Get more information

Inflammatory biomarkers and pendelluft magnitude in ards patients transitioning from controlled to partial support ventilation by Cornejo, Rodrigo A., Arellano, Daniel H., Ruiz-Rudolph, Pablo, Guiñez, Dannette V., Morais, Caio C. A., Gajardo, Abraham I. J., Lazo, Marioli T., Brito, Roberto E., Cerda, María A., González, Sedric J., Rojas, Verónica A., Diaz, Gonzalo A., López, Lorena D. M., Medel, Juan N., Soto, Dagoberto I., Bruhn, Alejandro R., Amato, Marcelo B. P., Estuardo, Nivia R.

“…The transition from controlled to partial support ventilation is a challenge in acute respiratory distress syndrome (ARDS) patients due to the risks of…”
Get full text

Evaluation of sublingual and gut mucosal microcirculation in sepsis: A quantitative analysis by Verdant, Colin L, De Backer, Daniel, Bruhn, Alejandro, Clausi, Carla M, Su, Fuhong, Wang, Zhen, Rodriguez, Hector, Pries, Axel R, Vincent, Jean-Louis

“…OBJECTIVE:To determine the relationship between sublingual and intestinal mucosal microcirculatory perfusion. DESIGN:Observational, experimental study…”
Get full text

Spontaneous breathing promotes lung injury in an experimental model of alveolar collapse by Bachmann, María Consuelo, Cruces, Pablo, Díaz, Franco, Oviedo, Vanessa, Goich, Mariela, Fuenzalida, José, Damiani, Luis Felipe, Basoalto, Roque, Jalil, Yorschua, Carpio, David, Hamidi Vadeghani, Niki, Cornejo, Rodrigo, Rovegno, Maximiliano, Bugedo, Guillermo, Bruhn, Alejandro, Retamal, Jaime

“…Vigorous spontaneous breathing has emerged as a promotor of lung damage in acute lung injury, an entity known as “patient self-inflicted lung injury”…”
Get full text

Non-lobar atelectasis generates inflammation and structural alveolar injury in the surrounding healthy tissue during mechanical ventilation by Retamal, Jaime, Bergamini, Bruno Curty, Carvalho, Alysson R, Bozza, Fernando A, Borzone, Gisella, Borges, João Batista, Larsson, Anders, Hedenstierna, Göran, Bugedo, Guillermo, Bruhn, Alejandro

“…When alveoli collapse the traction forces exerted on their walls by adjacent expanded units may increase and concentrate. These forces may promote its…”
Get full text

Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure? by Dubo, Sebastián, Valenzuela, Emilio Daniel, Aquevedo, Andrés, Jibaja, Manuel, Berrutti, Dolores, Labra, Christian, Lagos, Rossana, García, María Fernanda, Ramírez, Vanessa, Tobar, Milton, Picoita, Fabricio, Peláez, Cristian, Carpio, David, Alegría, Leyla, Hidalgo, Carolina, Godoy, Karen, Bruhn, Alejandro, Hernández, Glenn, Bakker, Jan, Castro, Ricardo

“…The spontaneous breathing trial (SBT) assesses the risk of weaning failure by evaluating some physiological responses to the massive venous return increase…”
Get full text

Pendelluft in hypoxemic patients resuming spontaneous breathing: proportional modes versus pressure support ventilation by Arellano, Daniel H., Brito, Roberto, Morais, Caio C. A., Ruiz-Rudolph, Pablo, Gajardo, Abraham I. J., Guiñez, Dannette V., Lazo, Marioli T., Ramirez, Ivan, Rojas, Verónica A., Cerda, María A., Medel, Juan N., Illanes, Victor, Estuardo, Nivia R., Bruhn, Alejandro R., Brochard, Laurent J., Amato, Marcelo B. P., Cornejo, Rodrigo A.

“…Background Internal redistribution of gas, referred to as pendelluft, is a new potential mechanism of effort-dependent lung injury. Neurally-adjusted…”
Get full text

Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study by Basoalto, Roque, Damiani, L. Felipe, Jalil, Yorschua, Bachmann, María Consuelo, Oviedo, Vanessa, Alegría, Leyla, Valenzuela, Emilio Daniel, Rovegno, Maximiliano, Ruiz-Rudolph, Pablo, Cornejo, Rodrigo, Retamal, Jaime, Bugedo, Guillermo, Thille, Arnaud W., Bruhn, Alejandro

“…Background Prophylactic high-flow nasal cannula (HFNC) oxygen therapy can decrease the risk of extubation failure. It is frequently used in the postextubation…”
Get full text

Continuous prolonged prone positioning in COVID-19-related ARDS: a multicenter cohort study from Chile by Cornejo, Rodrigo A., Montoya, Jorge, Gajardo, Abraham I. J., Graf, Jerónimo, Alegría, Leyla, Baghetti, Romyna, Irarrázaval, Anita, Santis, César, Pavez, Nicolás, Leighton, Sofía, Tomicic, Vinko, Morales, Daniel, Ruiz, Carolina, Navarrete, Pablo, Vargas, Patricio, Gálvez, Roberto, Espinosa, Victoria, Lazo, Marioli, Pérez-Araos, Rodrigo A., Garay, Osvaldo, Sepúlveda, Patrick, Martinez, Edgardo, Bruhn, Alejandro

“…Background Prone positioning is currently applied in time-limited daily sessions up to 24 h which determines that most patients require several sessions…”
Get full text

Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP β -Lactamase Biosensor by Andresen, Max, Araos, Joaquin, Wong, Kwok-Yin, Leung, Yun-Chung, So, Lok-Yan, Wong, Wai-Ting, Cabrera, Salvador, Silva, Camila, Alegria, Leyla, Bruhn, Alejandro, Soto, Dagoberto

“…The use of antibiotics is mandatory in patients during extracorporeal membrane oxygenation (ECMO) support. Clinical studies have shown high variability in the…”
Get full text

Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study by Ospina-Tascón, Gustavo A., Bautista, Diego F., Madriñán, Humberto J., Valencia, Juan D., Bermúdez, William F., Quiñones, Edgardo, Calderón-Tapia, Luis Eduardo, Hernandez, Glenn, Bruhn, Alejandro, De Backer, Daniel

“…Background Ventilation/perfusion inequalities impair gas exchange in acute respiratory distress syndrome (ARDS). Although increased dead-space ventilation ( V…”
Get full text

Impact of exposure time in awake prone positioning on clinical outcomes of patients with COVID-19-related acute respiratory failure treated with high-flow nasal oxygen: a multicenter cohort study by Esperatti, Mariano, Busico, Marina, Fuentes, Nora Angélica, Gallardo, Adrian, Osatnik, Javier, Vitali, Alejandra, Wasinger, Elizabeth Gisele, Olmos, Matías, Quintana, Jorgelina, Saavedra, Santiago Nicolas, Lagazio, Ana Inés, Andrada, Facundo Juan, Kakisu, Hiromi, Romano, Nahuel Esteban, Matarrese, Agustin, Mogadouro, Mariela Adriana, Mast, Giuliana, Moreno, Claudia Navarro, Niquin, Greta Dennise Rebaza, Barbaresi, Veronica, Bruhn Cruz, Alejandro, Ferreyro, Bruno Leonel, Torres, Antoni

“…In patients with COVID-19-related acute respiratory failure (ARF), awake prone positioning (AW-PP) reduces the need for intubation in patients treated with…”
Get full text

Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients by Hernandez, Glenn, MD, Boerma, E. Christiaan, MD, PhD, Dubin, Arnaldo, MD, PhD, Bruhn, Alejandro, MD, PhD, Koopmans, Matty, RN, Edul, Vanina Kanoore, MD, Ruiz, Carolina, MD, Castro, Ricardo, MD, Pozo, Mario Omar, MD, Pedreros, Cesar, MD, Veas, Enrique, MD, Fuentealba, Andrea, MD, Kattan, Eduardo, MD, Rovegno, Maximiliano, MD, Ince, Can, PhD

“…Abstract Purpose The aims of this study are to determine the general relationship of perfused vessel density (PVD) to mortality and organ dysfunctions and to…”
Get full text

Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndrome by Alcayaga-Miranda, Francisca, Dutra Silva, Johnatas, Parada, Nicol, Andrade da Silva, Luisa Helena, Ferreira Cruz, Fernanda, Utreras, Yildy, Hidalgo, Yessia, Cádiz, María Ignacia, Tapia Limonchi, Rafael, Espinoza, Francisco, Bruhn, Alejandro, Khoury, Maroun, R M Rocco, Patricia, Cuenca, Jimena

“…Treatment for critical care conditions, such as acute respiratory distress syndrome (ARDS), requires ready-to-administer injectable mesenchymal stromal cells…”
Get full text