Search Results - "Brugnoli, Federica"

CD133 in Breast Cancer Cells: More than a Stem Cell Marker by Capitani, Silvano, Al-Qassab, Yasamin, Grassilli, Silvia, Brugnoli, Federica, Bertagnolo, Valeria

“…Initially correlated with hematopoietic precursors, the surface expression of CD133 was also found in epithelial and nonepithelial cells from adult tissues in…”
Get full text

Ethanol-based garlic extract prevents malignant evolution of non-invasive breast tumor cells induced by moderate hypoxia by Brugnoli, Federica, Tedeschi, Paola, Grassilli, Silvia, Maietti, Annalisa, Brandolini, Vincenzo, Bertagnolo, Valeria

“…In breast cancer, low oxygen availability is associated with a more aggressive phenotype and with malignant evolution of non-invasive cells. Natural compounds…”
Get full text

Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches by Grassilli, Silvia, Bertagnolo, Valeria, Brugnoli, Federica

“…The miR-29 family comprises miR-29a, miR-29b, and miR-29c, and these molecules play crucial and partially overlapped functions in solid tumors, in which the…”
Get full text

Chlorogenic acid permeation across intestinal cell monolayers: Influence by circadian rhythms in the presence of other natural polyphenols and by dopaminergic neuronal-like cells by Botti, Giada, Pavan, Barbara, Bianchi, Anna, Ferraro, Luca, Beggiato, Sarah, Brugnoli, Federica, Bertagnolo, Valeria, Dalpiaz, Alessandro

“…[Display omitted] •Circadian rhythms influence the intestinal permeability of chlorogenic acid (CGA)•Gallic acid, but not other polyphenols, counteracts the…”
Get full text

Protective role of all-trans retinoic acid (ATRA) against hypoxia-induced malignant potential of non-invasive breast tumor derived cells by Al-Qassab, Yasamin, Grassilli, Silvia, Brugnoli, Federica, Vezzali, Federica, Capitani, Silvano, Bertagnolo, Valeria

“…The presence of hypoxic areas is common in all breast lesions but no data clearly correlate low oxygenation with the acquisition of malignant features by…”
Get full text

Integrative proteomic and functional analyses provide novel insights into the action of the repurposed drug candidate nitroxoline in AsPC-1 cells by Veschi, Serena, Ronci, Maurizio, Lanuti, Paola, De Lellis, Laura, Florio, Rosalba, Bologna, Giuseppina, Scotti, Luca, Carletti, Erminia, Brugnoli, Federica, Di Bella, Maria Cristina, Bertagnolo, Valeria, Marchisio, Marco, Cama, Alessandro

“…We recently identified nitroxoline as a repurposed drug candidate in pancreatic cancer (PC) showing a dose-dependent antiproliferative activity in different PC…”
Get full text

Up-modulation of PLC-β2 reduces the number and malignancy of triple-negative breast tumor cells with a CD133 + /EpCAM + phenotype: a promising target for preventing progression of TNBC by Brugnoli, Federica, Grassilli, Silvia, Lanuti, Paola, Marchisio, Marco, Al-Qassab, Yasamin, Vezzali, Federica, Capitani, Silvano, Bertagnolo, Valeria

“…The malignant potential of triple negative breast cancer (TNBC) is also dependent on a sub-population of cells with a stem-like phenotype. Among the cancer…”
Get full text

Cell-Impermeable Inhibitors Confirm That Intracellular Human Transglutaminase 2 Is Responsible for the Transglutaminase-Associated Cancer Phenotype by Gates, Eric W. J, Calvert, Nicholas D, Cundy, Nicholas J, Brugnoli, Federica, Navals, Pauline, Kirby, Alexia, Bianchi, Nicoletta, Adhikary, Gautam, Shuhendler, Adam J, Eckert, Richard L, Keillor, Jeffrey W

“…Transglutaminase 2 (TG2) is a multifunctional enzyme primarily responsible for crosslinking proteins. Ubiquitously expressed in humans, TG2 can act either as a…”
Get full text

Effects of Garlic on Breast Tumor Cells with a Triple Negative Phenotype: Peculiar Subtype-Dependent Down-Modulation of Akt Signaling by Brugnoli, Federica, Dell'Aira, Marcello, Tedeschi, Paola, Grassilli, Silvia, Pierantoni, Marina, Foschi, Rebecca, Bertagnolo, Valeria

“…Breast cancer includes tumor subgroups with morphological, molecular, and clinical differences. Intrinsic heterogeneity especially characterizes breast tumors…”
Get full text

Vav1 Down-Modulates Akt2 Expression in Cells from Pancreatic Ductal Adenocarcinoma: Nuclear Vav1 as a Potential Regulator of Akt Related Malignancy in Pancreatic Cancer by Grassilli, Silvia, Brugnoli, Federica, Lattanzio, Rossano, Buglioni, Simonetta, Bertagnolo, Valeria

“…Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive tumor malignancy worldwide, mainly due to uncontrolled metastasis. Among the numerous molecules…”
Get full text

Imidazo[1,2- b ]pyrazole-7-Carboxamide Derivative Induces Differentiation-Coupled Apoptosis of Immature Myeloid Cells Such as Acute Myeloid Leukemia and Myeloid-Derived Suppressor Cells by Kotogány, Edit, Balog, József Á, Nagy, Lajos I, Alföldi, Róbert, Bertagnolo, Valeria, Brugnoli, Federica, Demjén, András, Kovács, Anita K, Batár, Péter, Mezei, Gabriella, Szabó, Renáta, Kanizsai, Iván, Varga, Csaba, Puskás, László G, Szebeni, Gábor J

“…Chemotherapy-induced differentiation of immature myeloid progenitors, such as acute myeloid leukemia (AML) cells or myeloid-derived suppressor cells (MDSCs),…”
Get full text

Vav1 downmodulates Akt in different breast cancer subtypes: a new promising chance to improve breast cancer outcome by Grassilli, Silvia, Brugnoli, Federica, Lattanzio, Rossano, Marchisio, Marco, Perracchio, Letizia, Piantelli, Mauro, Bavelloni, Alberto, Capitani, Silvano, Bertagnolo, Valeria

“…Targeting different members of the Akt pathways is a promising therapeutic chance in solid tumors including breast cancer. The variable expression levels of…”
Get full text

The Effect of Different Storage Conditions on Phytochemical Composition, Shelf-Life, and Bioactive Compounds of Voghiera Garlic PDO by Tedeschi, Paola, Brugnoli, Federica, Merighi, Stefania, Grassilli, Silvia, Nigro, Manuela, Catani, Martina, Gessi, Stefania, Bertagnolo, Valeria, Travagli, Alessia, Caboni, Maria Fiorenza, Cavazzini, Alberto

“…Voghiera garlic is an Italian white garlic variety which obtained in 2010 the Protected Designation of Origin. It is widely used for culinary purposes or as an…”
Get full text

Phospholipase C-β2 promotes mitosis and migration of human breast cancer-derived cells by Bertagnolo, Valeria, Benedusi, Mascia, Brugnoli, Federica, Lanuti, Paola, Marchisio, Marco, Querzoli, Patrizia, Capitani, Silvano

“…Like most human neoplasm, breast cancer has aberrations in signal transduction elements that can lead to increased proliferative potential, apoptosis…”
Get full text

The Motility and Mesenchymal Features of Breast Cancer Cells Correlate with the Levels and Intracellular Localization of Transglutaminase Type 2 by Bianchi, Nicoletta, Brugnoli, Federica, Grassilli, Silvia, Bourgeois, Karine, Keillor, Jeffrey W, Bergamini, Carlo M, Aguiari, Gianluca, Volinia, Stefano, Bertagnolo, Valeria

“…We have investigated motility in breast cancer cell lines in association with the expression of Transglutaminase type 2 (TG2) as well as upon the…”
Get full text

Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA) by Brugnoli, Federica, Grassilli, Silvia, Cardinale, Vincenzo, Carpino, Guido, Gaudio, Eugenio, Alvaro, Domenico, Capitani, Silvano, Bertagnolo, Valeria

“…All-trans retinoic acid (ATRA) promotes the development and the function of insulin producing cells and induces partial differentiation of pancreatic tumor…”
Get more information

High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors: a role in modulating genes related to the efficiency of metastatic process by Grassilli, Silvia, Brugnoli, Federica, Lattanzio, Rossano, Rossi, Cosmo, Perracchio, Letizia, Mottolese, Marcella, Marchisio, Marco, Palomba, Maria, Nika, Ervin, Natali, Pier Giorgio, Piantelli, Mauro, Capitani, Silvano, Bertagnolo, Valeria

“…Vav1 is one of the signalling proteins normally restricted to hematopoietic cells that results ectopically expressed in solid tumors, including breast cancer…”
Get full text

Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: Role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation by Brugnoli, Federica, Lambertini, Elisabetta, Varin-Blank, Nadine, Piva, Roberta, Marchisio, Marco, Grassilli, Silvia, Miscia, Sebastiano, Capitani, Silvano, Bertagnolo, Valeria

“…Vav1 plays an important role in the all- trans retinoic acid (ATRA)-induced completion of the differentiation program of acute promyelocytic leukemia…”
Get full text

In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness by Brugnoli, Federica, Grassilli, Silvia, Piazzi, Manuela, Palomba, Maria, Nika, Ervin, Bavelloni, Alberto, Capitani, Silvano, Bertagnolo, Valeria

“…Beyond its possible correlation with stemness of tumor cells, CD133/prominin1 is considered an important marker in breast cancer, since it correlates with…”
Get full text

Insights into the development of insulin-producing cells: Precursors correlated involvement of microRNA panels by Pierantoni, Marina, Grassilli, Silvia, Brugnoli, Federica, Dell'Aira, Marcello, Bertagnolo, Valeria

“…Type 1 diabetes (T1D) is a chronic autoimmune condition characterized by the destruction of pancreatic β cells, recently estimated to affect approximately 8.75…”
Get full text