Search Results - "Brugman, Wim"

Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation by Peric-Hupkes, Daan, Meuleman, Wouter, Pagie, Ludo, Bruggeman, Sophia W.M., Solovei, Irina, Brugman, Wim, Gräf, Stefan, Flicek, Paul, Kerkhoven, Ron M., van Lohuizen, Maarten, Reinders, Marcel, Wessels, Lodewyk, van Steensel, Bas

“…The three-dimensional organization of chromosomes within the nucleus and its dynamics during differentiation are largely unknown. To visualize this process in…”
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Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells by Filion, Guillaume J., van Bemmel, Joke G., Braunschweig, Ulrich, Talhout, Wendy, Kind, Jop, Ward, Lucas D., Brugman, Wim, de Castro, Inês J., Kerkhoven, Ron M., Bussemaker, Harmen J., van Steensel, Bas

“…Chromatin is important for the regulation of transcription and other functions, yet the diversity of chromatin composition and the distribution along…”
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Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2 by van der Kammen, Rob, Song, Ji-Ying, de Rink, Iris, Janssen, Hans, Madonna, Stefania, Scarponi, Claudia, Albanesi, Cristina, Brugman, Wim, Innocenti, Metello

“…The Arp2/3 complex assembles branched actin filaments, which are key to many cellular processes, but its organismal roles remain poorly understood. Here, we…”
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Adjuvant capecitabine-containing chemotherapy benefit and homologous recombination deficiency in early-stage triple-negative breast cancer patients by de Boo, Leonora W., Jóźwiak, Katarzyna, Joensuu, Heikki, Lindman, Henrik, Lauttia, Susanna, Opdam, Mark, van Steenis, Charlaine, Brugman, Wim, Kluin, Roelof J. C., Schouten, Philip C., Kok, Marleen, Nederlof, Petra M., Hauptmann, Michael, Linn, Sabine C.

“…Background The addition of adjuvant capecitabine to standard chemotherapy of early-stage triple-negative breast cancer (TNBC) patients has improved survival in…”
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The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome by van Bemmel, Joke G, Pagie, Ludo, Braunschweig, Ulrich, Brugman, Wim, Meuleman, Wouter, Kerkhoven, Ron M, van Steensel, Bas

“…Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the…”
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Long-term outcomes of young, node-negative, chemotherapy-naïve, triple-negative breast cancer patients according to BRCA1 status by Wang, Yuwei, Dackus, Gwen M H E, Rosenberg, Efraim H, Cornelissen, Sten, de Boo, Leonora W, Broeks, Annegien, Brugman, Wim, Chan, Terry W S, van Diest, Paul J, Hauptmann, Michael, Ter Hoeve, Natalie D, Isaeva, Olga I, de Jong, Vincent M T, Jóźwiak, Katarzyna, Kluin, Roelof J C, Kok, Marleen, Koop, Esther, Nederlof, Petra M, Opdam, Mark, Schouten, Philip C, Siesling, Sabine, van Steenis, Charlaine, Voogd, Adri C, Vreuls, Willem, Salgado, Roberto F, Linn, Sabine C, Schmidt, Marjanka K

“…Due to the abundant usage of chemotherapy in young triple-negative breast cancer (TNBC) patients, the unbiased prognostic value of BRCA1-related biomarkers in…”
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Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene by Mittempergher, Lorenza, Piskorz, Anna M, Bosma, Astrid J, Michaut, Magali, Wisman, G Bea A, Kluin, Roelof J C, Nieuwland, Marja, Brugman, Wim, van der Ven, Kevin J W, Marass, Francesco, Morris, James, Rosenfeld, Nitzan, Jimenez-Linan, Mercedes, de Jong, Steven, van der Zee, Ate G J, Brenton, James D, Bernards, René

“…High-grade serous ovarian carcinoma (HGSOC) remains the deadliest form of epithelial ovarian cancer and despite major efforts little improvement in overall…”
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The T7-primer is a source of experimental bias and introduces variability between microarray platforms by Kerkhoven, Ron M, Sie, Daoud, Nieuwland, Marja, Heimerikx, Mike, De Ronde, Jorma, Brugman, Wim, Velds, Arno

“…Eberwine(-like) amplification of mRNA adds distinct 6-10 bp nucleotide stretches to the 5' end of amplified RNA transcripts. Analysis of over six thousand…”
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The X-ray Structure of trans-3-Chloroacrylic Acid Dehalogenase Reveals a Novel Hydration Mechanism in the Tautomerase Superfamily by de Jong, René M., Brugman, Wim, Poelarends, Gerrit J., Whitman, Christian P., Dijkstra, Bauke W.

“…Isomer-specific 3-chloroacrylic acid dehalogenases function in the bacterial degradation of 1,3-dichloropropene, a compound used in agriculture to kill…”
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Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer by Lips, Esther H., Kumar, Tapsi, Megalios, Anargyros, Visser, Lindy L., Sheinman, Michael, Fortunato, Angelo, Shah, Vandna, Hoogstraat, Marlous, Sei, Emi, Mallo, Diego, Roman-Escorza, Maria, Ahmed, Ahmed A., Xu, Mingchu, van den Belt-Dusebout, Alexandra W., Brugman, Wim, Casasent, Anna K., Clements, Karen, Davies, Helen R., Fu, Liping, Grigoriadis, Anita, Hardman, Timothy M., King, Lorraine M., Krete, Marielle, Kristel, Petra, de Maaker, Michiel, Maley, Carlo C., Marks, Jeffrey R., Menegaz, Brian A., Mulder, Lennart, Nieboer, Frank, Nowinski, Salpie, Pinder, Sarah, Quist, Jelmar, Salinas-Souza, Carolina, Schaapveld, Michael, Schmidt, Marjanka K., Shaaban, Abeer M., Shami, Rana, Sridharan, Mathini, Zhang, John, Stobart, Hilary, Collyar, Deborah, Nik-Zainal, Serena, Wessels, Lodewyk F. A., Hwang, E. Shelley, Navin, Nicholas E., Futreal, P. Andrew, Thompson, Alastair M., Wesseling, Jelle, Sawyer, Elinor J.

“…Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5–10%) of DCIS patients develop…”
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Clinical efficacy and biomarker analysis of pre-operative ipilimumab plus nivolumab in stage III urothelial cancer: The NABUCCO trial update by Stockem, Chantal, Gil Jimenez, Alberto, van Dorp, Jeroen, Van Dijk, Nick, van Montfoort, Maurits L, Alkemade, Maartje, Seignette, Iris M., Broeks, Annegien, Hooijberg, Erik, Brugman, Wim, Mertens, Laura, van Rhijn, Bas W.G., De Feijter, Jeantine M, van der Heijden, Toine, Mehra, Niven, Meijer, Richard P., Suelmann, Britt, Vis, Daniel J, Wessels, Lodewyk F.A., Van Der Heijden, Michiel Simon

“…4593 Background: In the NABUCCO trial, pre-operative ipilimumab (ipi) + nivolumab (nivo) was studied in patients (pts) with stage III (cT3-4aN0M0 or…”
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Platinum-Based Chemotherapy Induces Opposing Effects on Immunotherapy Response-Related Spatial and Stromal Biomarkers in the Bladder Cancer Microenvironment by Chelushkin, Maksim A, van Dorp, Jeroen, van Wilpe, Sandra, Seignette, Iris M, Mellema, Jan-Jaap J, Alkemade, Maartje, Gil-Jimenez, Alberto, Peters, Dennis, Brugman, Wim, Stockem, Chantal F, Hooijberg, Erik, Broeks, Annegien, van Rhijn, Bas W G, Mertens, Laura S, van der Heijden, Antoine G, Mehra, Niven, van Montfoort, Maurits L, Wessels, Lodewyk F A, Vis, Daniel J, van der Heijden, Michiel S

“…Platinum-based chemotherapy and immune checkpoint inhibitors are key components of systemic treatment for muscle-invasive and advanced urothelial cancer. The…”
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Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing by Majewski, Ian J, Mittempergher, Lorenza, Davidson, Nadia M, Bosma, Astrid, Willems, Stefan M, Horlings, Hugo M, de Rink, Iris, Greger, Liliana, Hooijer, Gerrit KJ, Peters, Dennis, Nederlof, Petra M, Hofland, Ingrid, de Jong, Jeroen, Wesseling, Jelle, Kluin, Roelof JC, Brugman, Wim, Kerkhoven, Ron, Nieboer, Frank, Roepman, Paul, Broeks, Annegien, Muley, Thomas R, Jassem, Jacek, Niklinski, Jacek, van Zandwijk, Nico, Brazma, Alvis, Oshlack, Alicia, van den Heuvel, Michel, Bernards, René

“…Oncogenic fusion genes that involve kinases have proven to be effective targets for therapy in a wide range of cancers. Unfortunately, the diagnostic…”
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Volatile Anesthetics Modulate Gene Expression in Breast and Brain Tumor Cells by Huitink, Johannes M., Heimerikxs, Mike, Nieuwland, Marja, Loer, Stephan A., Brugman, Wim, Velds, Arno, Sie, Daoud, Kerkhoven, Ron M.

“…Gene expression is increasingly used for diagnostic, prognostic, and therapeutic purposes in clinical practice. We tested the hypothesis that volatile…”
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Dendrimer-Mediated Transfer Printing of DNA and RNA Microarrays by Rozkiewicz, Dorota I, Brugman, Wim, Kerkhoven, Ron M, Ravoo, Bart Jan, Reinhoudt, David N

“…This paper describes a new method to replicate DNA and RNA microarrays. The technique, which facilitates positioning of DNA and RNA with submicron edge…”
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Copy number profiling by array comparative genomic hybridization identifies frequently occurring BRCA 2‐like male breast cancer by Biesma, Hedde D., Schouten, Philip C., Lacle, Miangela M., Sanders, Joyce, Brugman, Wim, Kerkhoven, Ron, Mandjes, Ingrid, van der Groep, Petra, van Diest, Paul J., Linn, Sabine C.

“…Genomic aberrations can be used to subtype breast cancer. In this study, we investigated DNA copy number (CN) profiles of 69 cases of male breast cancer (MBC)…”
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Copy number profiling by array comparative genomic hybridization identifies frequently occurring BRCA2-like male breast cancer by Biesma, Hedde D., Schouten, Philip C., Lacle, Miangela M., Sanders, Joyce, Brugman, Wim, Kerkhoven, Ron, Mandjes, Ingrid, van der Groep, Petra, van Diest, Paul J., Linn, Sabine C.

“…Genomic aberrations can be used to subtype breast cancer. In this study, we investigated DNA copy number (CN) profiles of 69 cases of male breast cancer (MBC)…”
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The Insulator Protein SU by van Bemmel, Joke G, Pagie, Ludo, Braunschweig, Ulrich, Brugman, Wim, Meuleman, Wouter, Kerkhoven, Ron M, van Steensel, Bas

“…Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the…”
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Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells by Filion, Guillaume J., van Bemmel, Joke G., Braunschweig, Ulrich, Talhout, Wendy, Kind, Jop, Ward, Lucas D., Brugman, Wim, de Castro, Ines J., Kerkhoven, Ron M., Bussemaker, Harmen J., van Steensel, Bas

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Dendrimer-Mediated Transfer Printing of DNA and RNA Microarrays by Rozkiewicz, Dorota I, Brugman, Wim, Kerkhoven, Ron M, Ravoo, Bart Jan, Reinhoudt, David N

“…This paper describes a new method to replicate DNA and RNA microarrays. The technique, which facilitates positioning of DNA and RNA with submicron edge…”
Get full text