Search Results - "Brugg, Bernard"

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity‐induced axonal degeneration by Vaur, Pauline, Brugg, Bernard, Mericskay, Mathias, Li, Zhenlin, Schmidt, Mark S., Vivien, Denis, Orset, Cyrille, Jacotot, Etienne, Brenner, Charles, Duplus, Eric

“…ABSTRACT NAD+ depletion is a common phenomenon in neurodegenerative pathologies. Excitotoxicity occurs in multiple neurologic disorders and NAD+ was shown to…”
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Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers by Peyrin, Jean-Michel, Deleglise, Bérangère, Saias, Laure, Vignes, Maéva, Gougis, Paul, Magnifico, Sebastien, Betuing, Sandrine, Pietri, Mathéa, Caboche, Jocelyne, Vanhoutte, Peter, Viovy, Jean-Louis, Brugg, Bernard

“…Various experimental models are used to study brain development and degeneration. They range from whole animal models, which preserve anatomical structures but…”
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Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics by Bosc, Elodie, Anastasie, Julie, Soualmia, Feryel, Coric, Pascale, Kim, Ju Youn, Wang, Lily Q., Lacin, Gullen, Zhao, Kaitao, Patel, Ronak, Duplus, Eric, Tixador, Philippe, Sproul, Andrew A., Brugg, Bernard, Reboud-Ravaux, Michelle, Troy, Carol M., Shelanski, Michael L., Bouaziz, Serge, Karin, Michael, El Amri, Chahrazade, Jacotot, Etienne D.

“…Caspase-2 (Casp2) is a promising therapeutic target in several human diseases, including nonalcoholic steatohepatitis (NASH) and Alzheimer’s disease (AD)…”
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Synapto-protective drugs evaluation in reconstructed neuronal network by Deleglise, Bérangère, Lassus, Benjamin, Soubeyre, Vaneyssa, Alleaume-Butaux, Aurélie, Hjorth, Johannes J, Vignes, Maéva, Schneider, Benoit, Brugg, Bernard, Viovy, Jean-Louis, Peyrin, Jean-Michel

“…Chronic neurodegenerative syndromes such as Alzheimer's and Parkinson's diseases, or acute syndromes such as ischemic stroke or traumatic brain injuries are…”
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Impact of Neurons on Patient-Derived Cardiomyocytes Using Organ-On-A-Chip and iPSC Biotechnologies by Bernardin, Albin A, Colombani, Sarah, Rousselot, Antoine, Andry, Virginie, Goumon, Yannick, Delanoë-Ayari, Hélène, Pasqualin, Côme, Brugg, Bernard, Jacotot, Etienne D, Pasquié, Jean-Luc, Lacampagne, Alain, Meli, Albano C

“…In the heart, cardiac function is regulated by the autonomic nervous system (ANS) that extends through the myocardium and establishes junctions at the sinus…”
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Wallerian-Like Degeneration of Central Neurons After Synchronized and Geometrically Registered Mass Axotomy in a Three-Compartmental Microfluidic Chip by Kilinc, Devrim, Peyrin, Jean-Michel, Soubeyre, Vanessa, Magnifico, Sébastien, Saias, Laure, Viovy, Jean-Louis, Brugg, Bernard

“…Degeneration of central axons may occur following injury or due to various diseases and it involves complex molecular mechanisms that need to be elucidated…”
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Nuclear Translocation of NF-κ B is Increased in Dopaminergic Neurons of Patients with Parkinson Disease by Hunot, Stephane, Brugg, Bernard, Ricard, Damien, Michel, Patrick P., Muriel, Marie-Paule, Ruberg, Merle, Faucheux, Baptiste A., Agid, Yves, Hirsch, Etienne C.

“…Evidence from postmortem studies suggest an involvement of oxidative stress in the degeneration of dopaminergic neurons in Parkinson disease (PD) that have…”
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Induction of early Purkinje cell dendritic differentiation by thyroid hormone requires RORα by Boukhtouche, Fatiha, Brugg, Bernard, Wehrlé, Rosine, Bois-Joyeux, Brigitte, Danan, Jean-Louis, Dusart, Isabelle, Mariani, Jean

“…The active form (T3) of thyroid hormone (TH) controls critical aspects of cerebellar development, such as migration of postmitotic neurons and terminal…”
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Rorα, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: From development to ageing by Boukhtouche, Fatiha, Doulazmi, Mohamed, Frederic, Florence, Dusart, Isabelle, Brugg, Bernard, Mariani, Jean

“…RORα (Retinoid-relatedOrphanReceptor) is a transcription factor belonging to the superfamily of nuclear receptors. The spontaneousstaggerer (sg) mutation,…”
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Phosphorylation and transcriptional activity regulation of retinoid-related orphan receptor alpha 1 by protein kinases C by Duplus, Eric, Gras, Christelle, Soubeyre, Vanessa, Vodjdani, Guilan, Lemaigre-Dubreuil, Yolande, Brugg, Bernard

“…Retinoid-related orphan receptor α1 (RORα1) is a member of the nuclear receptor superfamily. It is highly expressed in CNS particularly in the cerebellum…”
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Ceramide induces apoptosis in cultured mesencephalic neurons by Brugg, B, Michel, P P, Agid, Y, Ruberg, M

“…The death of dopaminergic and other neurons in primary cultures of the mesencephalon could be induced by treatment with ceramide, as in lymphocytes where it…”
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Mitochondrial Free Radical Signal in Ceramide‐Dependent Apoptosis: A Putative Mechanism for Neuronal Death in Parkinson's Disease by France‐Lanord, Valentine, Brugg, Bernard, Michel, Patrick P., Agid, Yves, Ruberg, Merle

“…: Activation of the apoptogenic sphingomyelin‐dependent signaling pathway in neuronally differentiated PC12 cells with cell‐permeant C2‐ceramide resulted in a…”
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Opposing Roles of Elk-1 and Its Brain-specific Isoform, Short Elk-1, in Nerve Growth Factor-induced PC12 Differentiation by Vanhoutte, Peter, Nissen, Johan L., Brugg, Bernard, Gaspera, Bruno Della, Besson, Marie-Jo, Hipskind, Robert A., Caboche, Jocelyne

“…The ternary complex factor Elk-1, a major nuclear target of extracellular signal-regulated kinases, is a strong transactivator of serum-responsive element…”
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Silencing of the Charcot–Marie–Tooth associated MTMR2 gene decreases proliferation and enhances cell death in primary cultures of Schwann cells by Chojnowski, Alexandre, Ravisé, Nicole, Bachelin, Corinne, Depienne, Christel, Ruberg, Merle, Brugg, Bernard, Laporte, Jocelyn, Baron-Van Evercooren, Anne, LeGuern, Eric

“…Abstract Loss of function of the myotubularin (MTM)-related protein 2 (MTMR2) in Schwann cells causes Charcot–Marie–Tooth disease type 4B1, a severe…”
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Nicotinamide riboside, a form of vitamin B 3 , protects against excitotoxicity-induced axonal degeneration by Vaur, Pauline, Brugg, Bernard, Mericskay, Mathias, Li, Zhenlin, Schmidt, Mark S, Vivien, Denis, Orset, Cyrille, Jacotot, Etienne, Brenner, Charles, Duplus, Eric

“…NAD depletion is a common phenomenon in neurodegenerative pathologies. Excitotoxicity occurs in multiple neurologic disorders and NAD was shown to prevent…”
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Neuro-cardiac organ-on-a-chip using patient specific induced pluripotent stem cells and microfluidic devices by Bernardin, Albin, Colombani, Sarah, Brugg, Bernard, Jacotot, Etienne, Meli, Albano, Lacampagne, Alain

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Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate by Annweiler, Cédric, Brugg, Bernard, Peyrin, Jean-Michel, Bartha, Robert, Beauchet, Olivier

“…Abstract The currently available drugs for treatment of Alzheimer's disease are symptomatic and only temporarily slow down the natural history of the disease…”
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Dysregulated Neurotransmission induces Trans-synaptic degeneration in reconstructed Neuronal Networks by Deleglise, Bérangère, Lassus, Benjamin, Soubeyre, Vanessa, Doulazmi, Mohamed, Brugg, Bernard, Vanhoutte, Peter, Peyrin, Jean-Michel

“…Increasing evidence suggests that pathological hallmarks of chronic degenerative syndromes progressively spread among interconnected brain areas in a…”
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RORalpha protects against oxidative stress by Brugg, Bernard

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Neuro-cardiac organ-a-chip using patient specific induced pluripotent stem cells and microfluidic devices by Bernardin, Albin, Colombani, Sarah, Brugg, Bernard, Jacotot, Etienne, Meli, Albano, Lacampagne, Alain

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