Search Results - "Brugarolas, Marc"
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Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
Published in BMC biology (28-02-2018)“…BACKGROUNDG-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities…”
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Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers
Published in PloS one (18-04-2013)“…Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine…”
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3
Striatal Pre- and Postsynaptic Profile of Adenosine A2A Receptor Antagonists
Published in PloS one (11-01-2011)“…Striatal adenosine A2A receptors (A2ARs) are highly expressed in medium spiny neurons (MSNs) of the indirect efferent pathway, where they heteromerize with…”
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Equilibrative Nucleoside Transporter ENT1 as a Biomarker of Huntington Disease
Published in Neurobiology of disease (01-12-2016)“…Abstract The initial goal of this study was to investigate alterations in adenosine A2A receptor (A2A R) density or function in a rat model of Huntington…”
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Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds
Published in Communications biology (23-04-2019)“…The mammalian olfactory system uses hundreds of specialized G-protein-coupled olfactory receptors (ORs) to discriminate a nearly unlimited number of odorants…”
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6
Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs
Published in BMC biology (05-04-2016)“…G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of…”
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Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer
Published in Proceedings of the National Academy of Sciences - PNAS (07-07-2015)“…Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the…”
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Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists
Published in PloS one (11-01-2011)“…Striatal adenosine A(2A) receptors (A(2A)Rs) are highly expressed in medium spiny neurons (MSNs) of the indirect efferent pathway, where they heteromerize with…”
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9
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes
Published in Purinergic signalling (27-04-2024)Get full text
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10
A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes
Published in Purinergic signalling (01-09-2013)“…Astrocytes play a key role in modulating synaptic transmission by controlling extracellular gamma-aminobutyric acid (GABA) levels via GAT-1 and GAT-3 GABA…”
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11
Correction to: A 1 R-A 2A R heteromers coupled to G s and G i/0 proteins modulate GABA transport into astrocytes
Published in Purinergic signalling (01-06-2024)Get full text
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12
Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds
Published in Communications biology (23-04-2019)“…The mammalian olfactory system uses hundreds of specialized G-protein-coupled olfactory receptors (ORs) to discriminate a nearly unlimited number of odorants…”
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Journal Article -
13
Allosteric interactions between agonists and antagonists within the adenosine A2Areceptordopamine D₂ receptor heterotetramer
Published in Proceedings of the National Academy of Sciences - PNAS (07-07-2015)“…Adenosine A2Areceptor (A2AR)-dopamine D₂ receptor (D₂R) heteromers are key modulators of striatal neuronal function. It has been suggested that the…”
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Allosteric interactions between agonists and antagonists within the adenosine A 2A receptor-dopamine D 2 receptor heterotetramer
Published in Proceedings of the National Academy of Sciences - PNAS (07-07-2015)“…Significance G protein-coupled receptors (GPCRs) constitute the largest plasma membrane protein family involved in cell signaling. GPCR homodimers are…”
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Allosteric interactions between agonists and antagonists within the adenosine A^sub 2A^ receptor-dopamine D^sub 2^ receptor heterotetramer
Published in Proceedings of the National Academy of Sciences - PNAS (07-07-2015)“…Adenosine A... receptor (A...R)-dopamine D2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the…”
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Allosteric interactions between agonists and antagonists within the adenosine A sub( 2A) receptor-dopamine D sub( 2) receptor heterotetramer
Published in Proceedings of the National Academy of Sciences - PNAS (01-07-2015)“…Adenosine A... receptor (A...R)-dopamine D2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the…”
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G‐Protein‐Coupled Receptor Heteromers as Key Players in the Molecular Architecture of the Central Nervous System
Published in CNS neuroscience & therapeutics (01-08-2014)“…Summary The overall architecture of the nervous system, especially the CNS, is remarkable. The anatomy of the nervous system is constituted not only by…”
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Allosteric interactions between agonists and antagonists within the adenosine AâA receptor-dopamine Dâ receptor heterotetramer
Published in Proceedings of the National Academy of Sciences - PNAS (2015)“…Adenosine A âA receptor (A âAR)-dopamine D â receptor (D âR) heteromers are key modulators of striatal neuronal function. It has been suggested that…”
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19
Cocaine Inhibits Dopamine D.sub.2 Receptor Signaling via Sigma-1-D.sub.2 Receptor Heteromers
Published in PloS one (18-04-2013)“…Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D.sub.1 -like family of…”
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Journal Article -
20
Modulation of GABA Transport by Adenosine A1R–A2AR Heteromers, Which Are Coupled to Both Gs- and Gi/o-Proteins
Published in The Journal of neuroscience (02-11-2011)“…Astrocytes play a key role in modulating synaptic transmission by controlling the available extracellular GABA via the GAT-1 and GAT-3 GABA transporters…”
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