Search Results - "Bruey, J M"

Pre-processed caspase-9 contained in mitochondria participates in apoptosis by Costantini, P, Bruey, J-M, Castedo, M, Métivier, D, Loeffler, M, Susin, S A, Ravagnan, L, Zamzami, N, Garrido, C, Kroemer, Guido

“…As shown here, mitochondria purified from different organs (liver, brain, kidney, spleen and heart) contain both pro-caspase-9 and the processed, mature form…”
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Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo by BRUEY, Jean-Marie, PAUL, Catherine, FROMENTIN, Annie, HILPERT, Sophie, ARRIGO, André-Patrick, SOLARY, Eric, GARRIDO, Carmen

“…HSP27 form oligomeric structures up to 800 Kda. In cultured cells, the equilibrium between small and large oligomers shifted towards smaller oligomers when…”
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Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells by GURBUXANI, Sandeep, BRUEY, Jean-Marie, FROMENTIN, Annie, LARMONIER, Nicolas, PARCELLIER, Arnaud, JÄÄTTELÄ, Marja, MARTIN, Francois, SOLARY, Eric, GARRIDO, Carmen

“…Expression of inducible heat shock protein 70 (HSP70) in tumor cells has been proposed to enhance their immunogenicity. However, HSP70 has also been…”
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Serologic and molecular diagnosis of Colorado tick fever viral infections by Attoui, H, Billoir, F, Bruey, J M, de Micco, P, de Lamballerie, X

“…Molecular and serologic methods usable for the biological diagnosis of Coltivirus infection are reported. We designed a multiplex reverse…”
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Hsp27 negatively regulates cell death by interacting with cytochrome c by Garrido, Carmen, Bruey, Jean-Marie, Ducasse, Cécile, Bonniaud, Philippe, Ravagnan, Luigi, Susin, Santos A, Diaz-Latoud, Chantal, Gurbuxani, Sandeep, Arrigo, André-Patrick, Kroemer, Guido, Solary, Eric

“…Mammalian cells respond to stress by accumulating or activating a set of highly conserved proteins known as heat-shock proteins (HSPs). Several of these…”
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HSP27 inhibits cytochrome c‐dependent activation of procaspase‐9 by Garrido, Carmen, Bruey, Jean‐Marie, Fromentin, Annie, Hammann, Arlette, Patrick Arrigo, André, Solary, Eric

“…ABSTRACTWe have previously shown that the small heat shock protein HSP27 inhibited apoptotic pathways triggered by a variety of stimuli in mammalian cells. The…”
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The PAAD/PYRIN-Family Protein ASC Is a Dual Regulator of a Conserved Step in Nuclear Factor κB Activation Pathways by Stehlik, Christian, Fiorentino, Loredana, Dorfleutner, Andrea, Bruey, Jean-Marie, Ariza, Eugenia M., Sagara, Junji, Reed, John C.

“…Apoptosis-associated speck-like protein containing a Caspase recruitment domain (ASC) belongs to a large family of proteins that contain a Pyrin, AIM, ASC, and…”
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Modulation of apoptotic pathways triggered by cytotoxic agents by Solary, E, Plenchette, S, Sordet, O, Rébé, C, Ducoroy, P, Filomenko, R, Bruey, J M, Droin, N, Corcos, L

“…Anticancer drugs can induce tumour cell death by apoptosis. The main pathway from specific damage induced by the drug to apoptosis involves activation of…”
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Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis by Sordet, Olivier, Rébé, Cédric, Leroy, Ingrid, Bruey, Jean-Marie, Garrido, Carmen, Miguet, Carole, Lizard, Gérard, Plenchette, Stéphanie, Corcos, Laurent, Solary, Eric

“…Exposure of U937 human leukemic cells to the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) induces their differentiation into…”
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Effects of inhaled seralutinib on right ventricular-pulmonary arterial (RV-PA) coupling and right heart function in pulmonary arterial hypertension (PAH) by Frantz, R, Tello, K, Moles, V M, Solomon, S D, Cravets, M, Osterhout, R, Bruey, J M, Roscigno, R F, Aranda, R, Vachiery, J L, Badagliacca, R, Benza, R L, Mclaughlin, V V, Zisman, L S, Ghofrani, H A

“…Abstract Background Impaired RV-PA coupling portends a poor prognosis in PAH, and right ventricular free wall strain/systolic pulmonary artery pressure…”
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Selective inhibition of apoptosis by TPA-induced differentiation of U937 leukemic cells by Sordet, O, Bettaieb, A, Bruey, J M, Eymin, B, Droin, N, Ivarsson, M, Garrido, C, Solary, E

“…U937 leukemic cells treated for 24 h with 16 nM 12-O-tetradecanoylphorbol 13-acetate (TPA), that induces their macrophagic terminal differentiation, become…”
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DOP05 Target engagement and pharmacodynamic biomarker analysis following treatment with the oral gut-targeted HIF-1α stabilizer GB004 in a Phase 1b trial in Active Ulcerative Colitis by Sandborn, W, Ding, Z, Osterhout, R, Feagan, B, Danese, S, Jucov, A, Bhandari, B R, Raghupathi, K, Olson, A, Van Biene, C, Ford, J, Aranda, R, Levesque, B G, Bruey, J M

“…Abstract Background Ulcerative colitis (UC) is characterized by the loss of epithelial barrier function and chronic mucosal inflammation. GB004 is an oral,…”
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ET-12 PHASE II STUDY OF ONARTUZUMAB PLUS BEVACIZUMAB VERSUS PLACEBO PLUS BEVACIZUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA by Cloughesy, T., Finocchiaro, G., Belda-Iniesta, C., Recht, L., Brandes, A. A., Pineda, E., Mikkelsen, T., Chinot, O., Balana, C., Macdonald, D., Westphal, M., Hopkins, K., Weller, M., Bruey, J.-M., Liu, B., Verret, W.

“…BACKGROUND: Glioblastomas are highly vascularized with elevated VEGF expression and have been shown to respond to the anti-VEGF antibody bevacizumab. High MET…”
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PAN1/NALP2/PYPAF2, an Inducible Inflammatory Mediator That Regulates NF-κB and Caspase-1 Activation in Macrophages by Bruey, Jean Marie, Bruey-Sedano, Nathalie, Newman, Ruchi, Chandler, Sharon, Stehlik, Christian, Reed, John C.

“…Genes encoding proteins with PYRIN/PAAD/DAPIN domains, a nucleotide binding fold (NACHT), and leucine rich repeats have recently been recognized as important…”
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Bcl-2 and Bcl-X sub(L) Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1 by Bruey, J M, Bruey-Sedano, N, Luciano, F, Zhai, D, Balpai, R, Xu, C, Kress, CL, Bailly-Maitre, B, Li, X, Osterman, A, Matsuzawa, Si, Terskikh, A V, Faustin, B, Reed, J C

“…Caspases are intracellular proteases that cleave substrates involved in apoptosis or inflammation. In C. elegans, a paradigm for caspase regulation exists in…”
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Dysregulation of Receptor Interacting Protein-2 and Caspase Recruitment Domain Only Protein Mediates Aberrant Caspase-1 Activation in Huntington's Disease by Wang, Xin, Wang, Hongyan, Figueroa, Bryan E, Zhang, Wen-hua, Huo, Chunfeng, Guan, Yingjun, Zhang, Yu, Bruey, Jean-Marie, Reed, John C, Friedlander, Robert M

“…Caspase-1 plays a role in the pathogenesis of a variety of neurological diseases. Caspase-1 activation is an early event in models of Huntington's disease…”
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