Search Results - "Bruennert, Daniela"

Sphingosine kinases negatively regulate the expression of matrix metalloproteases (MMP1 and MMP3) and their inhibitor TIMP3 genes via sphingosine 1‐phosphate in extravillous trophoblasts by Chahar, Kirti R., Kumar, Vijay, Sharma, Phulwanti K., Brünnert, Daniela, Kaushik, Vibha, Gehlot, Pragya, Shekhawat, Indu, Kumar, Suman, Sharma, Ajay Kumar, Kumari, Sandhya, Goyal, Pankaj

“…Purpose Extracellular matrix remodeling is essential for extravillous trophoblast (EVT) cell migration and invasion during placental development and regulated…”
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Dioncophyllines C 2 , D 2 , and F and Related Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ileboensis with Potent Activities against Plasmodium falciparum and against Multiple Myeloma and Leukemia Cell Lines by Li, Jun, Seupel, Raina, Feineis, Doris, Mudogo, Virima, Kaiser, Marcel, Brun, Reto, Brünnert, Daniela, Chatterjee, Manik, Seo, Ean-Jeong, Efferth, Thomas, Bringmann, Gerhard

“…Dioncophylline F (1), the first 5,8'-coupled dioncophyllaceous alkaloid (i.e., lacking an oxygen function at C-6 and possessing an R-configuration at C-3), was…”
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The heat shock protein 70 inhibitor VER155008 suppresses the expression of HSP27, HOP and HSP90β and the androgen receptor, induces apoptosis, and attenuates prostate cancer cell growth by Brünnert, Daniela, Langer, Clara, Zimmermann, Luise, Bargou, Ralf C., Burchardt, Martin, Chatterjee, Manik, Stope, Matthias B.

“…Heat shock proteins (HSPs) are molecular chaperones that play a pivotal role in correct folding, stabilization and intracellular transport of many client…”
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The intrinsic amyloidogenic propensity of cofilin-1 is aggravated by Cys-80 oxidation: A possible link with neurodegenerative diseases by Kaushik, Vibha, Brünnert, Daniela, Hanschmann, Eva-Maria, Sharma, Phulwanti Kumari, Anand, Bibin G., Kar, Karunakar, Kateriya, Suneel, Goyal, Pankaj

“…Cofilin-1, an actin dynamizing protein, forms actin-cofilin rods, which is one of the major events that exacerbates the pathophysiology of amyloidogenic…”
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Identification of gefitinib off-targets using a structure-based systems biology approach; their validation with reverse docking and retrospective data mining by Verma, Nidhi, Rai, Amit Kumar, Kaushik, Vibha, Brünnert, Daniela, Chahar, Kirti Raj, Pandey, Janmejay, Goyal, Pankaj

“…Gefitinib, an EGFR tyrosine kinase inhibitor, is used as FDA approved drug in breast cancer and non-small cell lung cancer treatment. However, this drug has…”
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STK35L1 regulates host cell cycle-related genes and is essential for Plasmodium infection during the liver stage of malaria by Sharma, Phulwanti Kumari, Kalia, Inderjeet, Kaushik, Vibha, Brünnert, Daniela, Quadiri, Afshana, Kashif, Mohammad, Chahar, Kirti Raj, Agrawal, Akhil, Singh, Agam Prasad, Goyal, Pankaj

“…Protein kinases of both the parasite and the host are crucial in parasite invasion and survival and might act as drug targets against drug-resistant malaria…”
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CD200 Expression on Multiple Myeloma Cells Induces Attenuation of T Cell-Mediated Cytotoxicity Via DOK2 by Shah, Pooja, Stuehmer, Thorsten, Bruennert, Daniela, Munawar, Umair, Leich, Ellen, Kraus, Sabrina, Hudecek, Michael, Chatterjee, Manik, Schlosser, Andreas, Bargou, Ralf C, Einsele, Hermann, Berberich-Siebelt, Friederike, Steinbrunn, Torsten

“…Introduction The CD200/CD200 receptor (CD200R) axis is known to exert immunoregulatory effects in myeloid-derived cells and constitutes a putative immune…”
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Immune Checkpoint CD200/CD200R Decreases T Cell-Mediated Cytotoxicity Via Dok2 and Is Regulated By P53 in Multiple Myeloma by Shah, Pooja, Stuehmer, Thorsten, Haertle, Larissa, Bruennert, Daniela, Munawar, Umair, Leich, Ellen, Kraus, Sabrina, Hudecek, Michael, Chatterjee, Manik, Schlosser, Andreas, Kortuem, Martin, Bargou, Ralf C, Einsele, Hermann, Berberich-Siebelt, Friederike, Steinbrunn, Torsten

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Thrombin stimulates gene expression and secretion of IL-11 via protease-activated receptor-1 and regulates extravillous trophoblast cell migration by Brünnert, Daniela, Shekhawat, Indu, Chahar, Kirti Raj, Ehrhardt, Jens, Pandey, Janmejay, Yadav, Jay Kant, Zygmunt, Marek, Goyal, Pankaj

“…•Thrombin stimulates IL-11 expression and secretion in extra villous trophoblast.•Activation of thrombin receptor PAR-1 regulates IL-11 expression and…”
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Epoxides related to dioncoquinone B: Synthesis, activity against multiple myeloma cells, and search for the target protein by Cheng, Xia, Zhang, Guoliang, Seupel, Raina, Feineis, Doris, Brünnert, Daniela, Chatterjee, Manik, Schlosser, Andreas, Bringmann, Gerhard

“…Epoxide 2b is an analog of the synthetic intermediate 2a en route to the polyketide-derived antitumoral naphthoquinone dioncoquinone B (1), isolated from cell…”
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Ugi Reaction-Derived α‑Acyl Aminocarboxamides Bind to Phosphatidylinositol 3‑Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma Cells by Bach, Matthias, Lehmann, Anna, Brünnert, Daniela, Vanselow, Jens T, Hartung, Andreas, Bargou, Ralf C, Holzgrabe, Ulrike, Schlosser, Andreas, Chatterjee, Manik

“…Heat shock transcription factor 1 (HSF1) has been identified as a therapeutic target for pharmacological treatment of multiple myeloma (MM). However, direct…”
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RAL Mediates Multiple Myeloma Cell Survival Independently of Oncogenic RAS by Seibold, Marcel, Stuehmer, Thorsten, Kremer, Nadine, Mottok, Anja, Scholz, Claus J, Bruennert, Daniela, Chatterjee, Manik, Leich, Ellen, Schlosser, Andreas, Rosenwald, Andreas, Einsele, Hermann, Bargou, Ralf C, Steinbrunn, Torsten

“…Introduction Mutation of RAS is one of the most frequent oncogenic lesions in human cancers and is present in up to half of primary multiple myeloma (MM)…”
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RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS by Seibold, Marcel, Stühmer, Thorsten, Kremer, Nadine, Mottok, Anja, Scholz, Claus-Jürgen, Schlosser, Andreas, Leich, Ellen, Holzgrabe, Ulrike, Brünnert, Daniela, Barrio, Santiago, Kortüm, Martin K, Solimando, Antonio G, Chatterjee, Manik, Einsele, Hermann, Rosenwald, Andreas, Bargou, Ralf C, Steinbrunn, Torsten

“…Oncogenic RAS provides crucial survival signaling for up to half of multiple myeloma cases, but has so far remained a clinically undruggable target. RAL is a…”
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Ancistrocladinium A Induces Apoptosis in Proteasome Inhibitor-Resistant Multiple Myeloma Cells: A Promising Therapeutic Agent Candidate by Brünnert, Daniela, Seupel, Raina, Goyal, Pankaj, Bach, Matthias, Schraud, Heike, Kirner, Stefanie, Köster, Eva, Feineis, Doris, Bargou, Ralf C, Schlosser, Andreas, Bringmann, Gerhard, Chatterjee, Manik

“…The N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A belongs to a novel class of natural products with potent antiprotozoal activity. Its effects…”
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Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways by Goyal, Pankaj, Brünnert, Daniela, Ehrhardt, Jens, Bredow, Marike, Piccenini, Svea, Zygmunt, Marek

“…Various cytokines derived from placental cells are essential for normal placenta development and successful pregnancy. Interleukin-6 (IL-6) is a…”
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Cofilin oligomer formation occurs in vivo and is regulated by cofilin phosphorylation by Goyal, Pankaj, Pandey, Dharmendra, Brünnert, Daniela, Hammer, Elke, Zygmunt, Marek, Siess, Wolfgang

“…ADF/cofilin proteins are key regulators of actin dynamics. Their function is inhibited by LIMK-mediated phosphorylation at Ser-3. Previous in vitro studies…”
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Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells by Gehlot, Pragya, Brünnert, Daniela, Kaushik, Vibha, Yadav, Arpana, Bage, Saloni, Gaur, Kritika, Saini, Mahesh, Ehrhardt, Jens, Manjunath, Gowrang Kasaba, Kumar, Abhishek, Kasliwal, Neena, Sharma, Ajay Kumar, Zygmunt, Marek, Goyal, Pankaj

“…Plasminogen activator inhibitor-1 (PAI-1/Serpin E1) is classically known for its antifibrinolytic activity via inhibiting uPA and tPA of the fibrinolytic…”
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Dioncophyllines C sub(2), D sub(2), and F and Related Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ileboensis with Potent Activities against Plasmodium falciparum and against Multiple Myeloma and Leukemia Cell Lines by Li, Jun, Seupel, Raina, Feineis, Doris, Mudogo, Virima, Kaiser, Marcel, Brun, Reto, Bruennert, Daniela, Chatterjee, Manik, Seo, Ean-Jeong, Efferth, Thomas, Bringmann, Gerhard

“…Dioncophylline F (1), the first 5,8'-coupled dioncophyllaceous alkaloid (i.e., lacking an oxygen function at C-6 and possessing an R-configuration at C-3), was…”
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High Prevalence of Intestinal Pathogens in Indigenous in Colombia by Kann, Simone, Bruennert, Daniela, Hansen, Jessica, Mendoza, Gustavo Andrés Concha, Gonzalez, José José Crespo, Quintero, Cielo Leonor Armenta, Hanke, Miriam, Hagen, Ralf Matthias, Backhaus, Joy, Frickmann, Hagen

“…Background: Intestinal infections remain a major public health burden in developing countries. Due to social, ecological, environmental, and cultural…”
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Expression, Intracellular Localization, and Prognostic Value of Plasminogen Activator Inhibitor 1 and PAI-1 RNA-Binding Protein 1 in Primary and Recurrent Ovarian Cancer: A Study of the Tumor Bank Ovarian Cancer Network by Koensgen, Dominique, Stope, Matthias B, Tuerbachova, Ivana, Bruennert, Daniela, Kohlmann, Thomas, Braicu, Ioana, Sehouli, Jalid, Denkert, Carsten, Darb-Esfahani, Silvia, Stickeler, Elmar, Sofroni, Dumitru, Dahl, Edgar, Mustea, Alexander

“…The plasminogen activator system plays a key role in ovarian cancer (OC) tumor progression. The plasminogen activator inhibitor type 1 (PAI-1) and the recently…”
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