Search Results - "Bruenle, Steffen"
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Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7
Published in Cell (22-08-2019)“…The CC chemokine receptor 7 (CCR7) balances immunity and tolerance by homeostatic trafficking of immune cells. In cancer, CCR7-mediated trafficking leads to…”
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Femtosecond-to-millisecond structural changes in a light-driven sodium pump
Published in Nature (London) (09-07-2020)“…Light-driven sodium pumps actively transport small cations across cellular membranes 1 . These pumps are used by microorganisms to convert light into membrane…”
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Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons
Published in Nature communications (14-09-2017)“…Historically, room-temperature structure determination was succeeded by cryo-crystallography to mitigate radiation damage. Here, we demonstrate that serial…”
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Dynamics and mechanism of a light-driven chloride pump
Published in Science (American Association for the Advancement of Science) (25-02-2022)“…Chloride transport by microbial rhodopsins is an essential process for which molecular details such as the mechanisms that convert light energy to drive ion…”
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The Crystal Structure of RosB: Insights into the Reaction Mechanism of the First Member of a Family of Flavodoxin‐like Enzymes
Published in Angewandte Chemie International Edition (19-01-2017)“…8‐demethyl‐8‐aminoriboflavin‐5′‐phosphate (AFP) synthase (RosB) catalyzes the key reaction of roseoflavin biosynthesis by forming AFP from…”
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Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism
Published in Proceedings of the National Academy of Sciences - PNAS (26-12-2019)“…The molybdenum storage protein (MoSto) deposits large amounts of molybdenum as polyoxomolybdate clusters in a heterohexameric (αβ)₃ cage-like protein complex…”
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The Molybdenum Storage Protein: A soluble ATP hydrolysis‐dependent molybdate pump
Published in The FEBS journal (01-12-2018)“…A continuous FeMo cofactor supply for nitrogenase maturation is ensured in Azotobacter vinelandii by developing a cage‐like molybdenum storage protein (MoSto)…”
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Die Kristallstruktur von RosB: Einblicke in den Reaktionsmechanismus des ersten Mitglieds einer flavodoxinähnlichen Enzymfamilie
Published in Angewandte Chemie (19-01-2017)“…Die 8-Demethyl-8-aminoriboflavin-5'-phosphat(AFP)-Synthase RosB katalysiert die Schlusselreaktion der Roseoflavinbiosynthese, die Bildung von AFP aus…”
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