Search Results - "Bruder, Jan"

Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling by Reinhardt, Peter, Glatza, Michael, Hemmer, Kathrin, Tsytsyura, Yaroslav, Thiel, Cora S, Höing, Susanne, Moritz, Sören, Parga, Juan A, Wagner, Lydia, Bruder, Jan M, Wu, Guangming, Schmid, Benjamin, Röpke, Albrecht, Klingauf, Jürgen, Schwamborn, Jens C, Gasser, Thomas, Schöler, Hans R, Sterneckert, Jared

“…Phenotypic drug discovery requires billions of cells for high-throughput screening (HTS) campaigns. Because up to several million different small molecules…”
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A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids by Renner, Henrik, Grabos, Martha, Becker, Katharina J, Kagermeier, Theresa E, Wu, Jie, Otto, Mandy, Peischard, Stefan, Zeuschner, Dagmar, TsyTsyura, Yaroslav, Disse, Paul, Klingauf, Jürgen, Leidel, Sebastian A, Seebohm, Guiscard, Schöler, Hans R, Bruder, Jan M

“…Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS)…”
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Combining Automated Organoid Workflows with Artificial Intelligence‐Based Analyses: Opportunities to Build a New Generation of Interdisciplinary High‐Throughput Screens for Parkinson's Disease and Beyond by Renner, Henrik, Schöler, Hans R., Bruder, Jan M.

“…Parkinson's disease (PD) is the second most common neurodegenerative disease and primarily characterized by the loss of dopaminergic neurons in the substantia…”
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Sclerostin and Insulin Resistance in Prediabetes: Evidence of a Cross Talk Between Bone and Glucose Metabolism by Daniele, Giuseppe, Winnier, Deidre, Mari, Andrea, Bruder, Jan, Fourcaudot, Marcel, Pengou, Zuo, Tripathy, Devjit, Jenkinson, Christopher, Folli, Franco

“…A gene mutation of the Wnt/β-catenin signaling cascade is present in rare patients with the insulin resistance syndrome. Sclerostin is a circulating peptide…”
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Permissive epigenomes endow reprogramming competence to transcriptional regulators by Kim, Kee-Pyo, Choi, Jinmi, Yoon, Juyong, Bruder, Jan M., Shin, Borami, Kim, Jonghun, Arauzo-Bravo, Marcos J., Han, Dong, Wu, Guangming, Han, Dong Wook, Kim, Johnny, Cramer, Patrick, Schöler, Hans R.

“…Identifying molecular and cellular processes that regulate reprogramming competence of transcription factors broadens our understanding of reprogramming…”
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The Use of FRAX in Identifying Women Less Than 65 Years Needing Bone Mineral Density Testing by Ghannam, Sammar, Blaney, Hanna, Gelfond, Jonathan, Bruder, Jan M.

“…The purpose of this study is to determine if the United States Preventive Services Task Force (USPSTF) screening guideline for osteoporosis identifies women…”
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Cell-Type-Specific High Throughput Toxicity Testing in Human Midbrain Organoids by Renner, Henrik, Becker, Katharina J., Kagermeier, Theresa E., Grabos, Martha, Eliat, Farsam, Günther, Patrick, Schöler, Hans R., Bruder, Jan M.

“…Toxicity testing is a crucial step in the development and approval of chemical compounds for human contact and consumption. However, existing model systems…”
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Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas by Toledo, Rodrigo A, Qin, Yuejuan, Cheng, Zi-Ming, Gao, Qing, Iwata, Shintaro, Silva, Gustavo M, Prasad, Manju L, Ocal, I Tolgay, Rao, Sarika, Aronin, Neil, Barontini, Marta, Bruder, Jan, Reddick, Robert L, Chen, Yidong, Aguiar, Ricardo C T, Dahia, Patricia L M

“…Pheochromocytomas and paragangliomas (PPGL) are genetically heterogeneous tumors of neural crest origin, but the molecular basis of most PPGLs is unknown. We…”
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Tissue clearing may alter emission and absorption properties of common fluorophores by Eliat, Farsam, Sohn, Rebecca, Renner, Henrik, Kagermeier, Theresa, Volkery, Stefan, Brinkmann, Heike, Kirschnick, Nils, Kiefer, Friedemann, Grabos, Martha, Becker, Katharina, Bedzhov, Ivan, Schöler, Hans R., Bruder, Jan M.

“…In recent years, 3D cell culture has been gaining a more widespread following across many fields of biology. Tissue clearing enables optical analysis of intact…”
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Fluorescence-based Single-cell Analysis of Whole-mount-stained and Cleared Microtissues and Organoids for High Throughput Screening by Renner, Henrik, Otto, Mandy, Grabos, Martha, Schöler, Hans R, Bruder, Jan M

“…Three-dimensional (3D) cell culture, especially in the form of organ-like microtissues ("organoids"), has emerged as a novel tool potentially mimicking human…”
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Generation and Maintenance of Homogeneous Human Midbrain Organoids by Renner, Henrik, Grabos, Martha, Schöler, Hans R, Bruder, Jan M

“…Three-dimensional cell cultures ("organoids") promise to better recapitulate native tissue physiology than traditional 2D cultures and are becoming…”
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Three-Dimensional Cell Culture Systems in Pediatric and Adult Brain Tumor Precision Medicine by Riedel, Nicole C, de Faria, Flavia W, Alfert, Amelie, Bruder, Jan M, Kerl, Kornelius

“…Primary brain tumors often possess a high intra- and intertumoral heterogeneity, which fosters insufficient treatment response for high-grade neoplasms,…”
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Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update by Armaiz-Pena, Gustavo, Flores, Shahida K, Cheng, Zi-Ming, Zhang, Xhingyu, Esquivel, Emmanuel, Poullard, Natalie, Vaidyanathan, Anusha, Liu, Qianqian, Michalek, Joel, Santillan-Gomez, Alfredo A, Liss, Michael, Ahmadi, Sara, Katselnik, Daniel, Maldonado, Enrique, Salgado, Sarimar Agosto, Jimenez, Camilo, Fishbein, Lauren, Hamidi, Oksana, Else, Tobias, Lechan, Ron, Tischler, Art S, Benn, Diana E, Dwight, Trisha, Clifton-Bligh, Rory, Sanso, Gabriela, Barontini, Marta, Vincent, Deepa, Aronin, Neil, Biondi, Bernadette, Koops, Maureen, Bowhay-Carnes, Elizabeth, Gimenez-Roqueplo, Anne-Paule, Alvarez-Eslava, Andrea, Bruder, Jan M, Kitano, Mio, Burnichon, Nelly, Ding, Yanli, Dahia, Patricia L M

“…Abstract Purpose This work aimed to evaluate genotype-phenotype associations in individuals carrying germline variants of transmembrane protein 127 gene…”
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Melanosomal dynamics assessed with a live-cell fluorescent melanosomal marker by Bruder, Jan M, Pfeiffer, Zachary A, Ciriello, Jonathan M, Horrigan, Diana M, Wicks, Nadine L, Flaherty, Benjamin, Oancea, Elena

“…Melanocytes present in skin and other organs synthesize and store melanin pigment within membrane-delimited organelles called melanosomes. Exposure of human…”
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Biomimetic materials replicating Schwann cell topography enhance neuronal adhesion and neurite alignment in vitro by Bruder, Jan M., Lee, Andrea P., Hoffman-Kim, Diane

“…It is well established that Schwann cells (SCs) promote and enhance axon guidance and nerve regeneration by providing multiple cues, including extracellular…”
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Abnormal bone mineral content and density in people with tetrasomy 18p by Moreira, Alvaro, Das, Hrishikesh, Hasi‐Zogaj, Minire, Soileau, Bridgette, Hill, Annice, Bruder, Jan M., Hale, Daniel E., Cody, Jannine D.

“…Tetrasomy 18p is a rare chromosomal abnormality, resulting from an additional iso‐chromosome composed of two copies of the short arm. It is characterized by…”
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All-in-one approach to culture, image and quantify large numbers of organoids at all scales

“…We developed a streamlined approach coupling microfabricated cell culture substrates, 3D single-objective light sheet imaging and artificial intelligence…”
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Chronic Myeloid Leukemia Associated Hypercalcemia: A Case Report and Literature Review by Toro-Tobón, David, Agosto, Sarimar, Ahmadi, Sara, Koops, Maureen, Bruder, Jan M

“…BACKGROUND Hypercalcemia associated with chronic myeloid leukemia (CML) is an ominous sign. Although rare, several cases have been reported and multiple…”
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Upregulation of TGF-β1 Expression May Be Necessary but Is Not Sufficient for Excessive Scarring by Campaner, Anelisa B., Ferreira, Lydia M., Gragnani, Alfredo, Bruder, Jan M., Cusick, Jennifer L., Morgan, Jeffrey R.

“…Transforming growth factor beta 1 (TGF-β1) upregulation has been implicated in hypertrophic scars and keloids, but it is unclear if it is the cause or an…”
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Correction: Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling by Reinhardt, Peter, Glatza, Michael, Hemmer, Kathrin, Tsytsyura, Yaroslav, Thiel, Cora S., Höing, Susanne, Moritz, Sören, Parga, Juan A., Wagner, Lydia, Bruder, Jan M., Wu, Guangming, Schmid, Benjamin, Röpke, Albrecht, Klingauf, Jürgen, Schwamborn, Jens C., Gasser, Thomas, Schöler, Hans R., Sterneckert, Jared

“…Download corrected item. https://doi.org/10.1371/annotation/6a917a2e-df4a-4ad9-99bb-6aa7218b833e.s006.cn and view the correct Figure S7 here: (2013)…”
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