Search Results - "Bruchs, Austin T."

Structure-driven development of a biomimetic rare earth artificial metalloprotein by Thompson, Peter J, Boggs, David G, Wilson, Charles A, Bruchs, Austin T, Velidandla, Uditha, Bridwell-Rabb, Jennifer, Olshansky, Lisa

“…The 2011 discovery of the first rare earth-dependent enzyme in methylotrophic AM1 prompted intensive research toward understanding the unique chemistry at play…”
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Harnessing Aromatic‐Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification by Yu, Zhen, Kreitler, Dale F., Chiu, Yin Ting T., Xu, Ruiwen, Bruchs, Austin T., Bingman, Craig A., Gellman, Samuel H.

“…Peptide engineering efforts have delivered drugs for diverse human diseases. Side chain alteration is among the most common approaches to designing new…”
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Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo by Liu, Shi, Yu, Zhen, Daley, Eileen J, Bingman, Craig A, Bruchs, Austin T, Gardella, Thomas J, Gellman, Samuel H

“…The parathyroid hormone type 1 receptor (PTHR1), a Class B GPCR, is activated by long polypeptides, including drugs for osteoporosis and hypoparathyroidism…”
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Harnessing Aromatic‐Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification by Yu, Zhen, Kreitler, Dale F., Chiu, Yin Ting T., Xu, Ruiwen, Bruchs, Austin T., Bingman, Craig A., Gellman, Samuel H.

“…Peptide engineering efforts have delivered drugs for diverse human diseases. Side chain alteration is among the most common approaches to designing new…”
Get full text