Search Results - "Bruce, Marc. A."

Atomic force mechanobiology of pluripotent stem cell-derived cardiomyocytes by Liu, Jianwei, Sun, Ning, Bruce, Marc A, Wu, Joseph C, Butte, Manish J

“…We describe a method using atomic force microscopy (AFM) to quantify the mechanobiological properties of pluripotent, stem cell-derived cardiomyocytes,…”
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Cytoskeletal adaptivity regulates T cell receptor signaling by Thauland, Timothy J, Hu, Kenneth H, Bruce, Marc A, Butte, Manish J

“…The factors that govern T cell activation control the initiation and progression of adaptive immune responses. T cells recognize their cognate antigen on the…”
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Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist by ANTAL-ZIMANYI, Ildiko, BRUCE, Marc. A, ORTIZ, Astrid A, POINDEXTER, Graham S, LEBOULLUEC, Karen L, IBEN, Lawrence G, MATTSON, Gail K, MCGOVERN, Rachel T, HOGAN, John B, LEAHY, Christina L, FLOWERS, Sharon C, STANLEY, Jennifer A

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Real-time GPU-based 3D Deconvolution by Bruce, Marc A, Butte, Manish J

“…Confocal microscopy is an oft-used technique in biology. Deconvolution of 3D images reduces blurring from out-of-focus light and enables quantitative analyses,…”
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Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications by Sun, Wenchao, Araci, Zeynep, Inayathullah, Mohammed, Manickam, Sathish, Zhang, Xuexiang, Bruce, Marc A., Marinkovich, M. Peter, Lane, Alfred T., Milla, Carlos, Rajadas, Jayakumar, Butte, Manish J.

“…We present a method of fabricating microneedles from polyvinylpyrrolidone (PVP) that enables delivery of intact proteins (or peptides) to the dermal layers of…”
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Spatiotemporally and mechanically controlled triggering of mast cells using atomic force microscopy by Hu, Kenneth K., Bruce, Marc A., Butte, Manish J.

“…Mast cells are thought to be sensitive to mechanical forces, for example, coughing in asthma or pressure in “physical urticarias.” Conversion of mechanical…”
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Multi-cellular interactions sustain long-term contractility of human pluripotent stem cell-derived cardiomyocytes by Burridge, Paul W, Metzler, Scott A, Nakayama, Karina H, Abilez, Oscar J, Simmons, Chelsey S, Bruce, Marc A, Matsuura, Yuka, Kim, Paul, Wu, Joseph C, Butte, Manish, Huang, Ngan F, Yang, Phillip C

“…Therapeutic delivery of cardiomyocytes derived from human pluripotent stem cells (hPSC-CMs) represents a novel clinical approach to regenerate the injured…”
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Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides by Epperson, James R., Bruce, Marc A., Catt, John D., Deskus, Jeffrey A., Hodges, Donald B., Karageorge, George N., Keavy, Daniel J., Mahle, Cathy D., Mattson, Ronald J., Ortiz, Astrid A., Parker, Michael F., Takaki, Katherine S., Watson, Brett T., Joseph P.Yevich

“…Compound 2b demonstrated full agonism at both human MT 1 and MT 2 receptors and demonstrated chronobiotic activity in both acute and chronic rat models,…”
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Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements by POINDEXTER, Graham S, BRUCE, Marc A, RUSSELL, John, ANTAL-ZIMANYI, Ildiko, BREITENBUCHER, J. Guy, HIGGINS, Mendi A, SIT, S.-Y, ROMINE, Jeffrey L, MARTIN, Scott W, WARD, Sally A, MCGOVERN, Rachel T, CLARKE, Wendy

“…Structure-activity studies around the urea linkage in BMS-193885 (4a) identified the cyanoguanidine moiety as an effective urea replacement in a series of…”
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Discovery of a Novel Class of Bicyclo[3.1.0]hexanylpiperazines as Noncompetitive Neuropeptide Y Y1 Antagonists by Hu, Shuanghua, Huang, Yazhong, Deshpande, Milind, Luo, Guanglin, Bruce, Marc A, Chen, Ling, Mattson, Gail, Iben, Lawrence G, Zhang, Jie, Russell, John W, Clarke, Wendy J, Hogan, John B, Ortiz, Astrid, Flint, Oliver, Henwood, Andrew, Gao, Qi, Antal-Zimanyi, Ildiko, Poindexter, Graham S

“…A novel class of bicyclo[3.1.0]­hexanylpiperazine neuropeptide Y (NPY) Y1 antagonists has been designed and synthesized. Scatchard binding analysis showed…”
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Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists by GUANGLIN LUO, MATTSON, Gail K, BRUCE, Marc A, WONG, Henry, MURPHY, Brian J, LONGHI, Daniel, ANTAL-ZIMANYI, Ildiko, POINDEXTER, Graham S

“…4-Amino-N-arylpiperidines serve as effective bioisosteres for N-arylpiperazines in the series of dihydropyridine NPY1 receptor antagonists. These were prepared…”
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Biochemical Stimulation of Immune Cells and Measurement of Mechanical Responses Using Atomic Force Microscopy by Hu, Kenneth H, Bruce, Marc A, Liu, Jianwei, Butte, Manish J

“…This manuscript details methods to ligate cell-surface receptors on live cells with precise spatiotemporal control using an atomic force microscope (AFM) to…”
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Dihydropyridine neuropeptide Y Y1 receptor antagonists by POINDEXTER, Graham S, BRUCE, Marc A, MATTSON, Gail K, KOZLOWSKI, Michael, ARCURI, Meredith, ANTAL-ZIMANYI, Ildiko, LEBOULLUEC, Karen L, MONKOVIC, Ivo, MARTIN, Scott W, PARKER, Eric M, IBEN, Larry G, MCGOVERN, Rachel T, ORTIZ, Astrid A, STANLEY, Jennifer A

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Cytoskeletal Stiffness Controls the Threshold of T Cell Activation by Bruce, Marc A., Butte, Manish J.

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The application of vinylogous iminium salts and related synthons to the regiocontrolled preparation of 2,3- and 2,5-disubstituted pyrroles by Gupton, John T, Petrich, Scott A, Smith, Lana L, Bruce, Marc A, Vu, Phong, Du, Karen X, Dueno, Eric E, Jones, Claude R, Sikorski, James A

“…The reaction of 1-substituted vinamidinium salts with sarcosine ethyl ester produced 2,3-disubstituted pyrroles; a similar reaction with glycine ethyl ester…”
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Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y 1 receptor antagonist by Antal-Zimanyi, Ildiko, Bruce, Marc. A., LeBoulluec, Karen L., Iben, Lawrence G., Mattson, Gail K., McGovern, Rachel T., Hogan, John B., Leahy, Christina L., Flowers, Sharon C., Stanley, Jennifer A., Ortiz, Astrid A., Poindexter, Graham S.

“…Treatment of obesity is still a large unmet medical need. Neuropeptide Y is the most potent orexigenic peptide in the animal kingdom. Its five cloned G-protein…”
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Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY 1 receptor antagonists by Luo, Guanglin, Mattson, Gail K., Bruce, Marc A., Wong, Henry, Murphy, Brian J., Longhi, Daniel, Antal-Zimanyi, Ildiko, Poindexter, Graham S.

“…4-Amino- N-arylpiperidines serve as effective bioisosteres for N-arylpiperazines in the series of dihydropyridine NPY 1 receptor antagonists. These were…”
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Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist by Antal-Zimanyi, Ildiko, Bruce, Marc A, Leboulluec, Karen L, Iben, Lawrence G, Mattson, Gail K, McGovern, Rachel T, Hogan, John B, Leahy, Christina L, Flowers, Sharon C, Stanley, Jennifer A, Ortiz, Astrid A, Poindexter, Graham S

“…Treatment of obesity is still a large unmet medical need. Neuropeptide Y is the most potent orexigenic peptide in the animal kingdom. Its five cloned G-protein…”
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The application of disubstituted vinylogous iminium salts and related synthons to the regiocontrolled preparation of unsymmetrical 2,3,4-trisubstituted pyrroles by Gupton, John T., Krumpe, Keith E., Burnham, Bruce S., Dwornik, Kate A., Petrich, Scott A., Du, Karen X., Bruce, Marc A., Vu, Phong, Vargas, Marian, Keertikar, Kartik M., Hosein, Kirsten N., Jones, Claude R., Sikorski, James A.

“…Reactions of 2,3-disubstituted chloropropeniminium salts and related synthons with ethyl glycinate, ethyl N-methylglycinate and ethyl N-benzylglycinate have…”
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Dihydropyridine neuropeptide Y Y 1 receptor antagonists 2 by Poindexter, Graham S, Bruce, Marc A, Breitenbucher, J.Guy, Higgins, Mendi A, Sit, S.-Y, Romine, Jeffrey L, Martin, Scott W, Ward, Sally A, McGovern, Rachel T, Clarke, Wendy, Russell, John, Antal-Zimanyi, Ildiko

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