Search Results - "Bruce, M"

Brown and Beige Fat: Physiological Roles beyond Heat Generation by Kajimura, Shingo, Spiegelman, Bruce M., Seale, Patrick

“…Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases…”
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Atmospheric Loss to Space and the History of Water on Mars by Jakosky, Bruce M

“…Mars is the nearest planet that potentially harbors life and that can be explored by humans, so its history of water is of considerable importance. Water was…”
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Cell biology of fat storage by Cohen, Paul, Spiegelman, Bruce M

“…The worldwide epidemic of obesity and type 2 diabetes has greatly increased interest in the biology and physiology of adipose tissues. Adipose (fat) cells are…”
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What We Talk About When We Talk About Fat by Rosen, Evan D., Spiegelman, Bruce M.

“…There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major…”
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New Advances in Adaptive Thermogenesis: UCP1 and Beyond by Chouchani, Edward T., Kazak, Lawrence, Spiegelman, Bruce M.

“…Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct capacity for thermogenesis could be leveraged as a therapy for…”
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The Influence of Social Desirability on Sexual Behavior Surveys: A Review by King, Bruce M.

“…Research in fields for which self-reported behaviors can be compared with factual data reveals that misreporting is pervasive and often extreme. The degree of…”
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PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein by Ohno, Haruya, Shinoda, Kosaku, Spiegelman, Bruce M., Kajimura, Shingo

“…Brown adipose tissue dissipates energy through heat and functions as a defense against cold and obesity. PPARγ ligands have been shown to induce the browning…”
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Reducing the energy cost of human walking using an unpowered exoskeleton by Collins, Steven H., Wiggin, M. Bruce, Sawicki, Gregory S.

“…With efficiencies derived from evolution, growth and learning, humans are very well-tuned for locomotion 1 . Metabolic energy used during walking can be partly…”
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Brown and Beige Fat: Molecular Parts of a Thermogenic Machine by Cohen, Paul, Spiegelman, Bruce M

“…The epidemic of obesity and type 2 diabetes has increased interest in pathways that affect energy balance in mammalian systems. Brown fat, in all of its…”
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Treatment of Obesity by Wolfe, Bruce M, Kvach, Elizaveta, Eckel, Robert H

“…This review focuses on the mechanisms underlying, and indications for, bariatric surgery in the reduction of cardiovascular disease (CVD), as well as other…”
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Comparison of a new type of Dark Matter with the Milky Way and M31 grand rotation curves by Law, Bruce M.

“…In the electron Born self-energy (eBse) model, free electrons are of finite-size and possess both a rest mass, m e , as well as, a Born mass, m e B = 74,000 m…”
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Treatment of Obesity: Weight Loss and Bariatric Surgery by Wolfe, Bruce M, Kvach, Elizaveta, Eckel, Robert H

“…This review focuses on the mechanisms underlying, and indications for, bariatric surgery in the reduction of cardiovascular disease (CVD), as well as other…”
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Banting Lecture 2012: Regulation of Adipogenesis: Toward New Therapeutics for Metabolic Disease by SPIEGELMAN, Bruce M

“…The Banting Medal for Scientific Achievement Award is the American Diabetes Association's highest scientific award and honors an individual who has made…”
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Adaptive thermogenesis in adipocytes: is beige the new brown? by Wu, Jun, Cohen, Paul, Spiegelman, Bruce M

“…One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose…”
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Proposed physical mechanism that gives rise to cosmic inflation by Law, Bruce M.

“…Early in the Universe a chemical equilibrium exists between photons and electron–positron ( e - e + ) pairs. In the electron Born self-energy (eBse) model the…”
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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human by Wu, Jun, Boström, Pontus, Sparks, Lauren M., Ye, Li, Choi, Jang Hyun, Giang, An-Hoa, Khandekar, Melin, Virtanen, Kirsi A., Nuutila, Pirjo, Schaart, Gert, Huang, Kexin, Tu, Hua, van Marken Lichtenbelt, Wouter D., Hoeks, Joris, Enerbäck, Sven, Schrauwen, Patrick, Spiegelman, Bruce M.

“…Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two…”
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Fat and Beyond: The Diverse Biology of PPARγ by Tontonoz, Peter, Spiegelman, Bruce M.

“…The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to a variety of…”
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Projecting ESRD Incidence and Prevalence in the United States through 2030 by McCullough, Keith P, Morgenstern, Hal, Saran, Rajiv, Herman, William H, Robinson, Bruce M

“…Population rates of obesity, hypertension, diabetes, age, and race can be used in simulation models to develop projections of ESRD incidence and prevalence…”
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The role of exercise and PGC1α in inflammation and chronic disease by Handschin, Christoph, Spiegelman, Bruce M

“…Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional…”
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A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat by Kazak, Lawrence, Chouchani, Edward T., Jedrychowski, Mark P., Erickson, Brian K., Shinoda, Kosaku, Cohen, Paul, Vetrivelan, Ramalingam, Lu, Gina Z., Laznik-Bogoslavski, Dina, Hasenfuss, Sebastian C., Kajimura, Shingo, Gygi, Steve P., Spiegelman, Bruce M.

“…Thermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their thermogenic activities can combat obesity and diabetes. Herein the…”
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