Search Results - "Bruce, Jeffrey"

Extent of resection in glioma – a review of the cutting edge by D’Amico, Randy S., MD, Englander, Zachary K., BA, Canoll, Peter, MD, PhD, Bruce, Jeffrey N., MD

“…Abstract Modern glioma surgery has evolved from the principle belief that safe, maximal tumor resection improves symptom management, quality of life,…”
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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy by Rehman, Sumaiyah K., Haynes, Jennifer, Collignon, Evelyne, Brown, Kevin R., Wang, Yadong, Nixon, Allison M.L., Bruce, Jeffrey P., Wintersinger, Jeffrey A., Singh Mer, Arvind, Lo, Edwyn B.L., Leung, Cherry, Lima-Fernandes, Evelyne, Pedley, Nicholas M., Soares, Fraser, McGibbon, Sophie, He, Housheng Hansen, Pollet, Aaron, Pugh, Trevor J., Haibe-Kains, Benjamin, Morris, Quaid, Ramalho-Santos, Miguel, Goyal, Sidhartha, Moffat, Jason, O’Brien, Catherine A.

“…Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents. It is increasingly appreciated that…”
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Translational genomics of nasopharyngeal cancer by Tsang, Chi Man, Lui, Vivian Wai Yan, Bruce, Jeffrey P., Pugh, Trevor J., Lo, Kwok Wai

“…Nasopharyngeal carcinoma (NPC), also named the Cantonese cancer, is a unique cancer with strong etiological association with infection of the Epstein-Barr…”
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Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma by Zhao, Junfei, Chen, Andrew X., Gartrell, Robyn D., Silverman, Andrew M., Aparicio, Luis, Chu, Tim, Bordbar, Darius, Shan, David, Samanamud, Jorge, Mahajan, Aayushi, Filip, Ioan, Orenbuch, Rose, Goetz, Morgan, Yamaguchi, Jonathan T., Cloney, Michael, Horbinski, Craig, Lukas, Rimas V., Raizer, Jeffrey, Rae, Ali I., Yuan, Jinzhou, Canoll, Peter, Bruce, Jeffrey N., Saenger, Yvonne M., Sims, Peter, Iwamoto, Fabio M., Sonabend, Adam M., Rabadan, Raul

“…Immune checkpoint inhibitors have been successful across several tumor types; however, their efficacy has been uncommon and unpredictable in glioblastomas…”
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EVOLVE: A Multicenter Open-Label Single-Arm Clinical and Translational Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer after PARP Inhibition Progression by Lheureux, Stephanie, Oaknin, Ana, Garg, Swati, Bruce, Jeffrey P, Madariaga, Ainhoa, Dhani, Neesha C, Bowering, Valerie, White, Justin, Accardi, Sarah, Tan, Qian, Braunstein, Marsela, Karakasis, Katherine, Cirlan, Iulia, Pedersen, Stephanie, Li, Tiantiam, Fariñas-Madrid, Lorena, Lee, Yeh Chen, Liu, Zhihui Amy, Pugh, Trevor J, Oza, Amit M

“…PARP inhibitors (PARPi) are standard-of-care therapy for high-grade serous ovarian cancer (HGSOC). We investigated combining cediranib (antiangiogenic) with…”
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Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype by Lei, Liang, Sonabend, Adam M, Guarnieri, Paolo, Soderquist, Craig, Ludwig, Thomas, Rosenfeld, Steven, Bruce, Jeffrey N, Canoll, Peter

“…Tumor heterogeneity is a major obstacle for finding effective treatment of Glioblastoma (GBM). Based on global expression analysis, GBM can be classified into…”
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HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models by Nguyen, Trang Thi Thu, Zhang, Yiru, Shang, Enyuan, Shu, Chang, Torrini, Consuelo, Zhao, Junfei, Bianchetti, Elena, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Harmanci, Arif O, Lei, Zhengdeng, Maienschein-Cline, Mark, Quinzii, Catarina M, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Bruce, Jeffrey N, Canoll, Peter, Siegelin, Markus D

“…The Warburg effect is a tumor-related phenomenon that could potentially be targeted therapeutically. Here, we showed that glioblastoma (GBM) cultures and…”
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Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers by Ye, Ling F, Chaudhary, Kunal R, Zandkarimi, Fereshteh, Harken, Andrew D, Kinslow, Connor J, Upadhyayula, Pavan S, Dovas, Athanassios, Higgins, Dominique M, Tan, Hui, Zhang, Yan, Buonanno, Manuela, Wang, Tony J. C, Hei, Tom K, Bruce, Jeffrey N, Canoll, Peter D, Cheng, Simon K, Stockwell, Brent R

“…Although radiation is widely used to treat cancers, resistance mechanisms often develop and involve activation of DNA repair and inhibition of apoptosis…”
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Patient-specific metrics of invasiveness reveal significant prognostic benefit of resection in a predictable subset of gliomas by Baldock, Anne L, Ahn, Sunyoung, Rockne, Russell, Johnston, Sandra, Neal, Maxwell, Corwin, David, Clark-Swanson, Kamala, Sterin, Greg, Trister, Andrew D, Malone, Hani, Ebiana, Victoria, Sonabend, Adam M, Mrugala, Maciej, Rockhill, Jason K, Silbergeld, Daniel L, Lai, Albert, Cloughesy, Timothy, McKhann, 2nd, Guy M, Bruce, Jeffrey N, Rostomily, Robert C, Canoll, Peter, Swanson, Kristin R

“…Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain parenchyma. Current methods of clinical imaging…”
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The integrated landscape of driver genomic alterations in glioblastoma by Frattini, Veronique, Trifonov, Vladimir, Chan, Joseph Minhow, Castano, Angelica, Lia, Marie, Abate, Francesco, Keir, Stephen T, Ji, Alan X, Zoppoli, Pietro, Niola, Francesco, Danussi, Carla, Dolgalev, Igor, Porrati, Paola, Pellegatta, Serena, Heguy, Adriana, Gupta, Gaurav, Pisapia, David J, Canoll, Peter, Bruce, Jeffrey N, McLendon, Roger E, Yan, Hai, Aldape, Ken, Finocchiaro, Gaetano, Mikkelsen, Tom, Privé, Gilbert G, Bigner, Darell D, Lasorella, Anna, Rabadan, Raul, Iavarone, Antonio

“…Anna Lasorella, Raul Rabadan, Antonio Iavarone and colleagues report an integrated analysis of genomic alterations in glioblastoma. They identify and…”
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Convection-enhanced drug delivery for glioblastoma: a review by D’Amico, Randy S., Aghi, Manish K., Vogelbaum, Michael A., Bruce, Jeffrey N.

“…Introduction Convection-enhanced delivery (CED) is a method of targeted, local drug delivery to the central nervous system (CNS) that bypasses the blood-brain…”
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Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states by Al-Dalahmah, Osama, Argenziano, Michael G., Kannan, Adithya, Mahajan, Aayushi, Furnari, Julia, Paryani, Fahad, Boyett, Deborah, Save, Akshay, Humala, Nelson, Khan, Fatima, Li, Juncheng, Lu, Hong, Sun, Yu, Tuddenham, John F., Goldberg, Alexander R., Dovas, Athanassios, Banu, Matei A., Sudhakar, Tejaswi, Bush, Erin, Lassman, Andrew B., McKhann, Guy M., Gill, Brian J. A., Youngerman, Brett, Sisti, Michael B., Bruce, Jeffrey N., Sims, Peter A., Menon, Vilas, Canoll, Peter

“…Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells…”
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Adavosertib plus gemcitabine for platinum-resistant or platinum-refractory recurrent ovarian cancer: a double-blind, randomised, placebo-controlled, phase 2 trial by Lheureux, Stephanie, Cristea, Mihaela C, Bruce, Jeffrey P, Garg, Swati, Cabanero, Michael, Mantia-Smaldone, Gina, Olawaiye, Alexander B, Ellard, Susan L, Weberpals, Johanne I, Wahner Hendrickson, Andrea E, Fleming, Gini F, Welch, Stephen, Dhani, Neesha C, Stockley, Tracy, Rath, Prisni, Karakasis, Katherine, Jones, Gemma N, Jenkins, Suzanne, Rodriguez-Canales, Jaime, Tracy, Michael, Tan, Qian, Bowering, Valerie, Udagani, Smitha, Wang, Lisa, Kunos, Charles A, Chen, Eric, Pugh, Trevor J, Oza, Amit M

“…The Wee1 (WEE1hu) inhibitor adavosertib and gemcitabine have shown preclinical synergy and promising activity in early phase clinical trials. We aimed to…”
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Single-cell transcriptome analysis of lineage diversity in high-grade glioma by Yuan, Jinzhou, Levitin, Hanna Mendes, Frattini, Veronique, Bush, Erin C, Boyett, Deborah M, Samanamud, Jorge, Ceccarelli, Michele, Dovas, Athanassios, Zanazzi, George, Canoll, Peter, Bruce, Jeffrey N, Lasorella, Anna, Iavarone, Antonio, Sims, Peter A

“…Despite extensive molecular characterization, we lack a comprehensive understanding of lineage identity, differentiation, and proliferation in high-grade…”
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Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL by Karpel-Massler, Georg, Ishida, Chiaki Tsuge, Bianchetti, Elena, Zhang, Yiru, Shu, Chang, Tsujiuchi, Takashi, Banu, Matei A., Garcia, Franklin, Roth, Kevin A., Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.

“…Certain gliomas often harbor a mutation in the activity center of IDH1 (R132H), which leads to the production of the oncometabolite 2-R-2-hydroxyglutarate…”
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Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism by Upadhyayula, Pavan S., Higgins, Dominique M., Mela, Angeliki, Banu, Matei, Dovas, Athanassios, Zandkarimi, Fereshteh, Patel, Purvi, Mahajan, Aayushi, Humala, Nelson, Nguyen, Trang T. T., Chaudhary, Kunal R., Liao, Lillian, Argenziano, Michael, Sudhakar, Tejaswi, Sperring, Colin P., Shapiro, Benjamin L., Ahmed, Eman R., Kinslow, Connor, Ye, Ling F., Siegelin, Markus D., Cheng, Simon, Soni, Rajesh, Bruce, Jeffrey N., Stockwell, Brent R., Canoll, Peter

“…Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant…”
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Microsurgical resection of pineal region tumors by Sonabend, Adam M., Bowden, Stephen, Bruce, Jeffrey N.

“…The extensive variety of possible histologic subtypes makes it imperative to establish a tissue diagnosis in patients with pineal region tumors. Management…”
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Frailty in Geriatric Glioblastoma Patients: A Predictor of Operative Morbidity and Outcome by Cloney, Michael, BA, D'Amico, Randy, MD, Lebovic, Jordan, BA, Nazarian, Matthew, BS, Zacharia, Brad E., MD, MS, Sisti, Michael B., MD, Bruce, Jeffrey N., MD, McKhann, Guy M., MD, Iwamoto, Fabio M., MD, Sonabend, Adam M., MD

“…Introduction Frailty is an emerging means of assessing overall health status and guiding management for geriatric patients. Frailty is associated with outcomes…”
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A Review of Therapeutic Agents Given by Convection-Enhanced Delivery for Adult Glioblastoma by Rolfe, Nathaniel W, Dadario, Nicholas B, Canoll, Peter, Bruce, Jeffrey N

“…Glioblastoma remains a devastating disease with a bleak prognosis despite continued research and numerous clinical trials. Convection-enhanced delivery offers…”
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MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma by Gill, Brian J., Pisapia, David J., Malone, Hani R., Goldstein, Hannah, Lei, Liang, Sonabend, Adam, Yun, Jonathan, Samanamud, Jorge, Sims, Jennifer S., Banu, Matei, Dovas, Athanassios, Teich, Andrew F., Sheth, Sameer A., McKhann, Guy M., Sisti, Michael B., Bruce, Jeffrey N., Sims, Peter A., Canoll, Peter

“…Glioblastomas (GBMs) diffusely infiltrate the brain, making complete removal by surgical resection impossible. The mixture of neoplastic and nonneoplastic…”
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