Search Results - "Bruce, Jeff"

Nasopharyngeal Cancer: Molecular Landscape by Bruce, Jeff P, Yip, Kenneth, Bratman, Scott V, Ito, Emma, Liu, Fei-Fei

“…Nasopharyngeal carcinoma (NPC) is a unique epithelial malignancy arising from the superior aspect of the pharyngeal mucosal space, associated with latent…”
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Somatic BRCA1/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition by Lheureux, Stephanie, Bruce, Jeff P, Burnier, Julia V, Karakasis, Katherine, Shaw, Patricia A, Clarke, Blaise A, Yang, S Y Cindy, Quevedo, Rene, Li, Tiantian, Dowar, Mark, Bowering, Valerie, Pugh, Trevor J, Oza, Amit M

“…Purpose Durable and long-term responses to the poly (ADP-ribose) polymerase inhibitor olaparib are observed in patients without BRCA1/2 mutations. However,…”
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Bamgineer: Introduction of simulated allele-specific copy number variants into exome and targeted sequence data sets by Samadian, Soroush, Bruce, Jeff P, Pugh, Trevor J

“…Somatic copy number variations (CNVs) play a crucial role in development of many human cancers. The broad availability of next-generation sequencing data has…”
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HPV Associated Head and Neck Cancer by Spence, Tara, Bruce, Jeff, Yip, Kenneth W, Liu, Fei-Fei

“…Head and neck cancers (HNCs) are a highly heterogeneous group of tumours that are associated with diverse clinical outcomes. Recent evidence has demonstrated…”
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Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis by Mesci, Aruz, Huang, Xiaoyong, Taeb, Samira, Jahangiri, Sahar, Kim, Yohan, Fokas, Emmanouil, Bruce, Jeff, Leong, Hon S, Liu, Stanley K

“…Background: MicroRNAs (miRs) are involved in the regulation of many processes that contribute to malignancy, including cell proliferation, radiation…”
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MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma by Bissey, Pierre-Antoine, Teng, Mona, Law, Jacqueline H, Shi, Wei, Bruce, Jeff P, Petit, Valentin, Tsao, Sai W, Yip, Kenneth W, Liu, Fei-Fei

“…A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy…”
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All is not lost: learning from 9p21 loss in cancer by Spiliopoulou, Pavlina, Yang, S.Y. Cindy, Bruce, Jeff P., Wang, Ben X., Berman, Hal K., Pugh, Trevor J., Siu, Lillian L.

“…The cancer research community continues to search for additional biomarkers of response and resistance to immune checkpoint treatment (ICT). The ultimate goal…”
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AACR Project GENIE: 100,000 Cases and Beyond by Pugh, Trevor J, Bell, Jonathan L, Bruce, Jeff P, Doherty, Gary J, Galvin, Matthew, Green, Michelle F, Hunter-Zinck, Haley, Kumari, Priti, Lenoue-Newton, Michele L, Li, Marilyn M, Lindsay, James, Mazor, Tali, Ovalle, Andrea, Sammut, Stephen-John, Schultz, Nikolaus, Yu, Thomas V, Sweeney, Shawn M, Bernard, Brady

“…The American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) is an international pan-cancer registry…”
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miR-218 Suppresses Nasopharyngeal Cancer Progression through Downregulation of Survivin and the SLIT2-ROBO1 Pathway by ALAJEZ, Nehad M, LENARDUZZI, Michelle, O'SULLIVAN, Brian, LIU, Fei-Fei, ITO, Emma, HUI, Angela B. Y, WEI SHI, BRUCE, Jeff, SHIJUN YUE, HUANG, Shao H, WEI XU, WALDRON, John

“…Nasopharayngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy most common in East Asia and Africa. Here we report frequent downregulation of…”
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Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape by Bruce, Jeff P., To, Ka-Fai, Lui, Vivian W. Y., Chung, Grace T. Y., Chan, Yuk-Yu, Tsang, Chi Man, Yip, Kevin Y., Ma, Brigette B. Y., Woo, John K. S., Hui, Edwin P., Mak, Michael K. F., Lee, Sau-Dan, Chow, Chit, Velapasamy, Sharmila, Or, Yvonne Y. Y., Siu, Pui Kei, El Ghamrasni, Samah, Prokopec, Stephenie, Wu, Man, Kwan, Johnny S. H., Liu, Yuchen, Chan, Jason Y. K., van Hasselt, C. Andrew, Young, Lawrence S., Dawson, Christopher W., Paterson, Ian C., Yap, Lee-Fah, Tsao, Sai-Wah, Liu, Fei-Fei, Chan, Anthony T. C., Pugh, Trevor J., Lo, Kwok-Wai

“…Interplay between EBV infection and acquired genetic alterations during nasopharyngeal carcinoma (NPC) development remains vague. Here we report a…”
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Novel insights into head and neck cancer using next-generation "omic" technologies by Sepiashvili, Lusia, Bruce, Jeff P, Huang, Shao Hui, O'Sullivan, Brian, Liu, Fei-Fei, Kislinger, Thomas

“…Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that develops via one of the two primary carcinogenic routes: chemical…”
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miRNA-95 Mediates Radioresistance in Tumors by Targeting the Sphingolipid Phosphatase SGPP1 by XIAOYONG HUANG, TAEB, Samira, BRISTOW, Robert G, LIU, Fei-Fei, LIU, Stanley K, JAHANGIRI, Sahar, EMMENEGGER, Urban, TRAN, Elisa, BRUCE, Jeff, MESCI, Aruz, KORPELA, Elina, VESPRINI, Danny, SHUN WONG, C

“…Radiation resistance poses a major clinical challenge in cancer treatment, but little is known about how microRNA (miR) may regulate this phenomenon. In this…”
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Developing a prognostic micro-RNA signature for human cervical carcinoma by How, Christine, Pintilie, Melania, Bruce, Jeff P, Hui, Angela B Y, Clarke, Blaise A, Wong, Philip, Yin, Shaoming, Yan, Rui, Waggott, Daryl, Boutros, Paul C, Fyles, Anthony, Hedley, David W, Hill, Richard P, Milosevic, Michael, Liu, Fei-Fei

“…Cervical cancer remains the third most frequently diagnosed and fourth leading cause of cancer death in women worldwide. We sought to develop a micro-RNA…”
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CD8+ Tumor-Infiltrating Lymphocyte Abundance Is a Positive Prognostic Indicator in Nasopharyngeal Cancer by Shi, Wei, Fijardo, Mackenzie, Bruce, Jeff P, Su, Jie, Xu, Wei, Bell, Rachel, Bissey, Pierre-Antoine, Hui, Angela B Y, Waldron, John, Pugh, Trevor J, Yip, Kenneth W, Liu, Fei-Fei

“…Tumor-infiltrating lymphocytes (TIL) are immune cell populations found within tumors, critical in the antigen-specific host immune response. In this study, we…”
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Tumor-derived exosomes and microvesicles in head and neck cancer: Implications for tumor biology and biomarker discovery by Principe, Simona, Hui, Angela Bik-Yu, Bruce, Jeff, Sinha, Ankit, Liu, Fei-Fei, Kislinger, Thomas

“…Exosomes and microvesicles (MVs) are nanometer‐sized, membranous vesicles secreted from many cell types into their surrounding extracellular space and into…”
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The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer by Kogo, Ryunosuke, How, Christine, Chaudary, Naz, Bruce, Jeff, Shi, Wei, Hill, Richard P, Zahedi, Payam, Yip, Kenneth W, Liu, Fei-Fei

“…Cervical cancer is the third most common cancer in women worldwide. In the present study, global microRNA profiling for 79 cervical cancer patient samples led…”
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The complexity of microRNAs in human cancer by Kwan, Jennifer Y. Y., Psarianos, Pamela, Bruce, Jeff P., Yip, Kenneth W., Liu, Fei-Fei

“…MicroRNAs (miRNAs) are small non-coding RNA molecules that have key regulatory roles in cancer, acting as both oncogenes and tumor suppressors. Due to the…”
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Significance of Dysregulated Metadherin and MicroRNA-375 in Head and Neck Cancer by HUI, Angela B. Y, BRUCE, Jeff P, GULLANE, Patrick, LILLIAN SIU, LIU, Fei-Fei, ALAJEZ, Nehad M, WEI SHI, SHIJUN YUE, PEREZ-ORDONEZ, Bayardo, WEI XU, O'SULLIVAN, Brian, WALDRON, John, CUMMINGS, Bernard

“…Despite recent improvements in local control of head and neck cancers (HNC), distant metastasis remains a major cause of death. Hence, further understanding of…”
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hsa‑miR‑24 suppresses metastasis in nasopharyngeal carcinoma by regulating the c‑Myc/epithelial‑mesenchymal transition axis by Su, Bojin, Xu, Tao, Bruce, Jeff P, Yip, Kenneth W, Zhang, Ning, Huang, Zeli, Zhang, Guoyi, Liu, Fei-Fei, Liang, Jiyong, Yang, Huiling, Claret, François X

“…Distant metastasis is the major contributor to treatment failure and mortality in patients with nasopharyngeal carcinoma (NPC). The lack of effective treatment…”
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Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape by Bruce, Jeff P., To, Ka-Fai, Lui, Vivian W. Y., Chung, Grace T. Y., Chan, Yuk-Yu, Tsang, Chi Man, Yip, Kevin Y., Ma, Brigette B. Y., Woo, John K. S., Hui, Edwin P., Mak, Michael K. F., Lee, Sau-Dan, Chow, Chit, Velapasamy, Sharmila, Or, Yvonne Y. Y., Siu, Pui Kei, El Ghamrasni, Samah, Prokopec, Stephenie, Wu, Man, Kwan, Johnny S. H., Liu, Yuchen, Chan, Jason Y. K., van Hasselt, C. Andrew, Young, Lawrence S., Dawson, Christopher W., Paterson, Ian C., Yap, Lee-Fah, Tsao, Sai-Wah, Liu, Fei-Fei, Chan, Anthony T. C., Pugh, Trevor J., Lo, Kwok-Wai

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