Search Results - "Bruce, A.J."

RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation by Cho, Hyun-Soo, Hayami, Shinya, Toyokawa, Gouji, Maejima, Kazuhiro, Yamane, Yuka, Suzuki, Takehiro, Dohmae, Naoshi, Kogure, Masaharu, Kang, Daechun, Neal, David E, Ponder, Bruce A.J, Yamaue, Hiroki, Nakamura, Yusuke, Hamamoto, Ryuji

“…Abstract It is well known that RB functions are regulated by posttranslational modifications such as phosphorylation and acetylation, but the significance of…”
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Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers by Hayami, Shinya, Kelly, John D., Cho, Hyun‐Soo, Yoshimatsu, Masanori, Unoki, Motoko, Tsunoda, Tatsuhiko, Field, Helen I., Neal, David E., Yamaue, Hiroki, Ponder, Bruce A.J., Nakamura, Yusuke, Hamamoto, Ryuji

“…A number of histone demethylases have been identified and biochemically characterized, but the pathological roles of their dysfunction in human disease like…”
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Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer by Pharoah, Paul D.P, Antoniou, Antonis C, Easton, Douglas F, Ponder, Bruce A.J

“…This article reviews the genetic susceptibility to breast cancer, with emphasis on genomewide association studies that have uncovered six single-nucleotide…”
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Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers by Yoshimatsu, Masanori, Toyokawa, Gouji, Hayami, Shinya, Unoki, Motoko, Tsunoda, Tatsuhiko, Field, Helen I., Kelly, John D., Neal, David E., Maehara, Yoshihiko, Ponder, Bruce A.J., Nakamura, Yusuke, Hamamoto, Ryuji

“…Protein arginine methylation is a novel post‐translational modification regulating a diversity of cellular processes, including histone functions, but the…”
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Enhanced Expression of EHMT2 Is Involved in the Proliferation of Cancer Cells through Negative Regulation of SIAH1 by Cho, Hyun-Soo, Kelly, John D, Hayami, Shinya, Toyokawa, Gouji, Takawa, Masahi, Yoshimatsu, Masanori, Tsunoda, Tatsuhiko, Field, Helen I, Neal, David E, Ponder, Bruce A.J, Nakamura, Yusuke, Hamamoto, Ryuji

“…Abstract EHMT2 is a histone lysine methyltransferase localized in euchromatin regions and acting as a corepressor for specific transcription factors. Although…”
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Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression by TAKAWA, Masashi, CHO, Hyun-Soo, DOHMAE, Naoshi, FIELD, Helen I, TSUNODA, Tatsuhiko, KOBAYASHI, Takaaki, AKASU, Takayuki, SUGIYAMA, Masanori, OHNUMA, Shin-Ichi, ATOMI, Yutaka, PONDER, Bruce A. J, NAKAMURA, Yusuke, HAYAMI, Shinya, HAMAMOTO, Ryuji, TOYOKAWA, Gouji, KOGURE, Masaharu, YAMANE, Yuka, IWAI, Yukiko, MAEJIMA, Kazuhiro, UEDA, Koji, MASUDA, Akiko

“…Although the physiologic significance of lysine methylation of histones is well known, whether lysine methylation plays a role in the regulation of nonhistone…”
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Demethylation of RB Regulator MYPT1 by Histone Demethylase LSD1 Promotes Cell Cycle Progression in Cancer Cells by CHO, Hyun-Soo, SUZUKI, Takehiro, FIELD, Helen I, PONDER, Bruce A. J, NAKAMURA, Yusuke, HAMAMOTO, Ryuji, DOHMAE, Naoshi, HAYAMI, Shinya, UNOKI, Motoko, YOSHIMATSU, Masanori, TOYOKAWA, Gouji, TAKAWA, Masashi, TAIPING CHEN, KURASH, Julia K

“…Histone demethylase LSD1 (also known as KDM1 and AOF2) is active in various cancer cells, but its biological significance in human carcinogenesis is…”
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The prevalence of burning mouth syndrome: a population-based study by Kohorst, J.J., Bruce, A.J., Torgerson, R.R., Schenck, L.A., Davis, M.D.P.

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A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression by Meyer, Kerstin B, Maia, Ana-Teresa, O'Reilly, Martin, Ghoussaini, Maya, Prathalingam, Radhika, Porter-Gill, Patricia, Ambs, Stefan, Prokunina-Olsson, Ludmila, Carroll, Jason, Ponder, Bruce A J

“…Genetic mapping studies have identified multiple cancer susceptibility regions at chromosome 8q24, upstream of the MYC oncogene. MYC has been widely presumed…”
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Polygenic susceptibility to breast cancer and implications for prevention by Pharoah, Paul D.P, Antoniou, Antonis, Bobrow, Martin, Zimmern, Ron L, Easton, Douglas F, Ponder, Bruce A.J

“…The knowledge of human genetic variation that will come from the human genome sequence makes feasible a polygenic approach to disease prevention, in which it…”
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Histone Lysine Methyltransferase Wolf-Hirschhorn Syndrome Candidate 1 Is Involved in Human Carcinogenesis through Regulation of the Wnt Pathway by Toyokawa, Gouji, Cho, Hyun-Soo, Masuda, Ken, Yamane, Yuka, Yoshimatsu, Masanori, Hayami, Shinya, Takawa, Masashi, Iwai, Yukiko, Daigo, Yataro, Tsuchiya, Eiju, Tsunoda, Tatsuhiko, Field, Helen I, Kelly, John D, Neal, David E, Maehara, Yoshihiko, Ponder, Bruce A.J, Nakamura, Yusuke, Hamamoto, Ryuji

“…Abstract A number of histone methyltransferases have been identified and biochemically characterized, but the pathologic roles of their dysfunction in human…”
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Risk Factors for the Incidence of Breast Cancer: Do They Affect Survival From the Disease? by BARNETT, Gillian C, SHAH, Mitul, REDMAN, Karen, EASTON, Douglas F, PONDER, Bruce A. J, PHAROAH, Paul D. P

“…Risk factors that influence the incidence of breast cancer may also affect survival after diagnosis. Data from 4,560 women with invasive breast cancer who had…”
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Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer by Meyer, Kerstin B, Maia, Ana-Teresa, O'Reilly, Martin, Teschendorff, Andrew E, Chin, Suet-Feung, Caldas, Carlos, Ponder, Bruce A J

“…The recent whole-genome scan for breast cancer has revealed the FGFR2 (fibroblast growth factor receptor 2) gene as a locus associated with a small, but highly…”
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Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B by Cho, Hyun-Soo, Shimazu, Tadahiro, Toyokawa, Gouji, Daigo, Yataro, Maehara, Yoshihiko, Hayami, Shinya, Ito, Akihiro, Masuda, Ken, Ikawa, Noriko, Field, Helen I., Tsuchiya, Eiju, Ohnuma, Shin-ichi, Ponder, Bruce A.J., Yoshida, Minoru, Nakamura, Yusuke, Hamamoto, Ryuji

“…Although heat-shock protein 70 (HSP70), an evolutionarily highly conserved molecular chaperone, is known to be post-translationally modified in various ways…”
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Telomere length in prospective and retrospective cancer case-control studies by Pooley, Karen A, Sandhu, Manjinder S, Tyrer, Jonathan, Shah, Mitul, Driver, Kristy E, Luben, Robert N, Bingham, Sheila A, Ponder, Bruce A J, Pharoah, Paul D P, Khaw, Kay-Tee, Easton, Douglas F, Dunning, Alison M

“…Previous studies have reported that shorter mean telomere length in lymphocytes was associated with increased susceptibility to common diseases of aging, and…”
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X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle by Perz-Edwards, Robert J, Irving, Thomas C, Baumann, Bruce A.J, Gore, David, Hutchinson, Daniel C, Kržič, Uroš, Porter, Rebecca L, Ward, Andrew B, Reedy, Michael K

“…Stretch activation is important in the mechanical properties of vertebrate cardiac muscle and essential to the flight muscles of most insects. Despite decades…”
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Phosphorylated Smooth Muscle Heavy Meromyosin Shows an Open Conformation Linked to Activation by Baumann, Bruce A.J., Taylor, Dianne W., Huang, Zhong, Tama, Florence, Fagnant, Patricia M., Trybus, Kathleen M., Taylor, Kenneth A.

“…Smooth muscle myosin and smooth muscle heavy meromyosin (smHMM) are activated by regulatory light chain phosphorylation, but the mechanism remains unclear…”
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Mutations truncating the EP300 acetylase in human cancers by Caldas, Carlos, Gayther, Simon A, Batley, Sarah J, Linger, Lori, Bannister, Andy, Thorpe, Karen, Chin, Suet-Feung, Daigo, Yataro, Russell, Paul, Wilson, Annie, Sowter, Heidi M, Delhanty, Joy D.A, Ponder, Bruce A.J, Kouzarides, Tony

“…The EP300 protein is a histone acetyltransferase that regulates transcription via chromatin remodelling and is important in the processes of cell proliferation…”
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Association between common variation in 120 candidate genes and breast cancer risk by Pharoah, Paul D P, Tyrer, Jonathan, Dunning, Alison M, Easton, Douglas F, Ponder, Bruce A J

“…Association studies in candidate genes have been widely used to search for common low penetrance susceptibility alleles, but few definite associations have…”
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Variants in DNA double-strand break repair genes and breast cancer susceptibility by Kuschel, Bettina, Auranen, Annika, McBride, Simon, Novik, Karen L., Antoniou, Antonis, Lipscombe, Julian M., Day, Nicholas E., Easton, Douglas F., Ponder, Bruce A.J., Pharoah, Paul D.P., Dunning, Alison

“…We performed genetic association studies in a population-based breast cancer case–control study analysing polymorphisms in genes involved in homologous…”
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