Search Results - "Brubaker, D"

Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer by Eno, Meredith S., Brubaker, Jason D., Campbell, John E., De Savi, Chris, Guzi, Timothy J., Williams, Brett D., Wilson, Douglas, Wilson, Kevin, Brooijmans, Natasja, Kim, Joseph, Özen, Ayşegül, Perola, Emanuele, Hsieh, John, Brown, Victoria, Fetalvero, Kristina, Garner, Andrew, Zhang, Zhuo, Stevison, Faith, Woessner, Rich, Singh, Jatinder, Timsit, Yoav, Kinkema, Caitlin, Medendorp, Clare, Lee, Christopher, Albayya, Faris, Zalutskaya, Alena, Schalm, Stefanie, Dineen, Thomas A.

“…While epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have changed the treatment landscape for EGFR mutant (L858R and ex19del)-driven…”
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Polarity-Controlled GaN/AlN Nucleation Layers for Selective-Area Growth of GaN Nanowire Arrays on Si(111) Substrates by Molecular Beam Epitaxy by Brubaker, Matt D, Duff, Shannon M, Harvey, Todd E, Blanchard, Paul T, Roshko, Alexana, Sanders, Aric W, Sanford, Norman A, Bertness, Kris A

“…We have demonstrated dramatic improvement in the quality of selective-area GaN nanowire growth by controlling the polarity of the underlying nucleation layers…”
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Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function by Fonseca, Maria I, Chu, Shuhui, Pierce, Aimee L, Brubaker, William D, Hauhart, Richard E, Mastroeni, Diego, Clarke, Elizabeth V, Rogers, Joseph, Atkinson, John P, Tenner, Andrea J

“…Chronic activation of the complement system and induced inflammation are associated with neuropathology in Alzheimer's disease (AD). Recent large genome wide…”
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Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics by Charest, Mark G, Lerner, Christian D, Brubaker, Jason D, Siegel, Dionicio R, Myers, Andrew G

“…Complex antibiotics based on natural products are almost invariably prepared by semisynthesis, or chemical transformation of the isolated natural products…”
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Increased risk of autoimmune disorders in infertile men: analysis of US claims data by Brubaker, W. D., Li, S., Baker, L. C., Eisenberg, M. L.

“…Summary Aberrations in reproductive fitness may be a harbinger of medical diseases in men. Existing data suggest that female infertility is associated with…”
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Near-field control and imaging of free charge carrier variations in GaN nanowires by Berweger, Samuel, Blanchard, Paul T., Brubaker, Matt D., Coakley, Kevin J., Sanford, Norman A., Wallis, Thomas M., Bertness, Kris A., Kabos, Pavel

“…Despite their uniform crystallinity, the shape and faceting of semiconducting nanowires (NWs) can give rise to variations in structure and associated…”
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Preferential and Specific Binding of Human αB-Crystallin to a Cataract-Related Variant of γS-Crystallin by Kingsley, Carolyn N., Brubaker, William D., Markovic, Stefan, Diehl, Anne, Brindley, Amanda J., Oschkinat, Hartmut, Martin, Rachel W.

“…Transparency in the eye lens is maintained via specific, functional interactions among the structural βγ- and chaperone α-crystallins. Here, we report the…”
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Cathepsin K mRNA and Protein Expression in Prostate Cancer Progression by Brubaker, KD, Vessella, RL, True, LD, Thomas, R, Corey, E

“…Prostate cancer (CaP) is the most commonly diagnosed malignancy in men and is often associated with bone metastases, which cause much of the morbidity…”
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Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications by Lim, Jongwon, Altman, Michael D., Baker, James, Brubaker, Jason D., Chen, Hongmin, Chen, Yiping, Kleinschek, Melanie A., Li, Chaomin, Liu, Duan, Maclean, John K.F., Mulrooney, Erin F., Presland, Jeremy, Rakhilina, Larissa, Smith, Graham F., Yang, Ruojing

“…[Display omitted] IRAK4 plays a critical role in the IL-1R and TLR signalling, and selective inhibition of the kinase activity of the protein represents an…”
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Intentional Foreign Body Ingestion: A Complex Case of Pica by Kupec, J., Ang-Rabanes, M., Brubaker, D., Drvar, T., Guinan, D., Marshalek, P.

“…Intentional ingestion of foreign objects, a form of self-injurious behavior, is rarely discussed in the medical literature but often requires extensive…”
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Administration of zoledronic acid enhances the effects of docetaxel on growth of prostate cancer in the bone environment by Brubaker, Kristen D, Brown, Lisha G, Vessella, Robert L, Corey, Eva

“…After development of hormone-refractory metastatic disease, prostate cancer is incurable. The recent history of chemotherapy has shown that with difficult…”
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Prevention of de novo hepatitis B in recipients of core antibody-positive livers with lamivudine and other nucleos(t)ides: a 12-year experience by Chang, Matthew S, Olsen, Sonja K, Pichardo, Elsa M, Stiles, Jessica B, Rosenthal-Cogan, Lori, Brubaker, William D, Guarrera, James V, Emond, Jean C, Brown, Jr, Robert S

“…Lamivudine (LAM) has been shown to prevent de novo hepatitis B virus (HBV) infection in recipients of hepatitis B core antibody (HBcAb)-positive liver…”
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Detection of an unintentional Si doping gradient in site-controlled GaN nanowires grown using a Si3N4 mask by spatially resolved cathodoluminescence and Raman spectroscopy by Gómez Ruiz, Mikel, Brubaker, Matt D., Bertness, Kris A., Roshko, Alexana, Tornatzky, Hans, Ramsteiner, Manfred, Brandt, Oliver, Lähnemann, Jonas

“…Highly uniform arrays of site-controlled GaN nanowires are synthesized by selective area growth using a Si3N4 mask and molecular beam epitaxy. Systematic…”
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Prostate cancer expression of runt-domain transcription factor Runx2, a key regulator of osteoblast differentiation and function by Brubaker, Kristen D., Vessella, Robert L., Brown, Lisha G., Corey, Eva

“…BACKGROUND Prostate cancer (CaP) bone metastases express numerous proteins associated with bone cells. Specific transcription factors, including Runx2,…”
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Function and Aggregation in Structural Eye Lens Crystallins by Roskamp, Kyle W, Paulson, Carolyn N, Brubaker, William D, Martin, Rachel W

“…Conspectus Crystallins are transparent, refractive proteins that contribute to the focusing power of the vertebrate eye lens. These proteins are extremely…”
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Counselors’ attitudes toward psychedelics and their use in therapy by Hearn, Benjamin G., Brubaker, Michael D., Richardson, George

“…The ‘‘psychedelic renaissance’’ is generating new evidence for psychedelics’ potential to treat numerous mental and substance use disorders. In particular, the…”
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Precision Targeted Therapy with BLU-667 for RET -Driven Cancers by Subbiah, Vivek, Gainor, Justin F, Rahal, Rami, Brubaker, Jason D, Kim, Joseph L, Maynard, Michelle, Hu, Wei, Cao, Qiongfang, Sheets, Michael P, Wilson, Douglas, Wilson, Kevin J, DiPietro, Lucian, Fleming, Paul, Palmer, Michael, Hu, Mimi I, Wirth, Lori, Brose, Marcia S, Ou, Sai-Hong Ignatius, Taylor, Matthew, Garralda, Elena, Miller, Stephen, Wolf, Beni, Lengauer, Christoph, Guzi, Timothy, Evans, Erica K

“…The receptor tyrosine kinase rearranged during transfection (RET) is an oncogenic driver activated in multiple cancers, including non-small cell lung cancer…”
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Preparation of the Isomeric Azaindoline Family by Intramolecular Carbolithiation by Bailey, William F, Salgaonkar, Paresh D, Brubaker, Jason D, Sharma, Vijayata

“…An operationally convenient, one-pot, three-step sequence has been developed that provides access to 3-substituted 4-, 5-, 6-, and 7-azaindolines…”
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The Psychometrics of the Mini-K by Richardson, George B, Chen, Ching-Chen, Dai, Chia-Liang, Brubaker, Michael D, Nedelec, Joseph L

“…Many published studies have employed the Mini-K to measure a single fast-slow life history dimension. However, the internal structure of the Mini-K has not…”
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Capillary-induced deformations of a thin elastic sheet by Brubaker, N. D., Lega, J.

“…We develop a three-dimensional model for capillary origami systems in which a rectangular plate has finite thickness, is allowed to stretch and undergoes small…”
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