Search Results - "Broyles, Connor N"
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Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations
Published in Circulation research (12-04-2019)“…RATIONALE:Subcellular Ca indicators have yet to be developed for the myofilament where disease mutation or small molecules may alter contractility through…”
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Associative learning drives longitudinally graded presynaptic plasticity of neurotransmitter release along axonal compartments
Published in eLife (14-03-2022)“…Anatomical and physiological compartmentalization of neurons is a mechanism to increase the computational capacity of a circuit, and a major question is what…”
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Fluorescent, Bioluminescent, and Optogenetic Approaches to Study Excitable Physiology in the Single Cardiomyocyte
Published in Cells (Basel, Switzerland) (31-05-2018)“…This review briefly summarizes the single cell application of classical chemical dyes used to visualize cardiomyocyte physiology and their undesirable…”
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Non-invasive phenotyping and drug testing in single cardiomyocytes or beta-cells by calcium imaging and optogenetics
Published in PloS one (05-04-2017)“…Identification of drug induced electrical instability of the heart curtails development, and introduction, of potentially proarrhythmic drugs. This problem…”
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Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes
Published in Journal of molecular and cellular cardiology (01-07-2023)“…We compared commonly used BAPTA-derived chemical Ca2+ dyes (fura2, Fluo-4, and Rhod-2) with a newer genetically encoded indicator (R-GECO) in single cell…”
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Comparing the effects of chemical Ca 2+ dyes and R-GECO on contractility and Ca 2+ transients in adult and human iPSC cardiomyocytes
Published in Journal of molecular and cellular cardiology (01-07-2023)“…We compared commonly used BAPTA-derived chemical Ca dyes (fura2, Fluo-4, and Rhod-2) with a newer genetically encoded indicator (R-GECO) in single cell models…”
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