Search Results - "Broxterman, Quirinus B."

Using the Right Green Yardstick: Why Process Mass Intensity Is Used in the Pharmaceutical Industry To Drive More Sustainable Processes by Jimenez-Gonzalez, Concepcion, Ponder, Celia S, Broxterman, Quirinus B, Manley, Julie B

“…There have been a many publications and much discussion about green metrics. While many have been proposed, The American Chemical Society Green Chemistry…”
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Key Green Engineering Research Areas for Sustainable Manufacturing: A Perspective from Pharmaceutical and Fine Chemicals Manufacturers by Jiménez-González, Concepción, Poechlauer, Peter, Broxterman, Quirinus B, Yang, Bing-Shiou, am Ende, David, Baird, James, Bertsch, Carl, Hannah, Robert E, Dell’Orco, Phil, Noorman, Henk, Yee, Sandy, Reintjens, Raf, Wells, Andrew, Massonneau, Viviane, Manley, Julie

“…In 2005, the American Chemical Society (ACS) Green Chemistry Institute (GCI) and global pharmaceutical companies established the ACS GCI Pharmaceutical…”
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Synthesis and Conformational Analysis of Efrapeptins by Weigelt, Sven, Huber, Thomas, Hofmann, Frank, Jost, Micha, Ritzefeld, Markus, Luy, Burkhard, Freudenberger, Christoph, Majer, Zsuzsanna, Vass, Elemér, Greie, Jörg-Christian, Panella, Lavinia, Kaptein, Bernard, Broxterman, Quirinus B., Kessler, Horst, Altendorf, Karlheinz, Hollósi, Miklós, Sewald, Norbert

“…The efrapeptin family of peptide antibiotics produced by the fungus Tolypocladium niveum, and the neo‐efrapeptins from the fungus Geotrichum candidumare…”
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Total Synthesis, Characterization, and Conformational Analysis of the Naturally Occurring Hexadecapeptide Integramide A and a Diastereomer by De Zotti, Marta, Damato, Francesca, Formaggio, Fernando, Crisma, Marco, Schievano, Elisabetta, Mammi, Stefano, Kaptein, Bernard, Broxterman, Quirinus B., Felock, Peter J., Hazuda, Daria J., Singh, Sheo B., Kirschbaum, Jochen, Brückner, Hans, Toniolo, Claudio

“…Integramide A is a 16‐amino acid peptide inhibitor of the enzyme HIV‐1 integrase. We have recently reported that the absolute stereochemistries of the…”
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Chiral Oligomers by Iterative Tandem Catalysis by van As, Bart A. C, van Buijtenen, Jeroen, Heise, Andreas, Broxterman, Quirinus B, Verzijl, Gerard K. M, Palmans, Anja R. A, Meijer, E. W

“…Iterative tandem catalysis is presented as a flexible tool for obtaining chiral macromolecules from racemic or prochiral monomers. Here, we combine…”
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Asymmetric enone epoxidation by short solid-phase bound peptides: Further evidence for catalyst helicity and catalytic activity of individual peptide strands by Berkessel, Albrecht, Koch, Burkhard, Toniolo, Claudio, Rainaldi, Mario, Broxterman, Quirinus B., Kaptein, Bernard

“…In the presence of short solid‐phase bound peptide catalysts, the Juliá–Colonna epoxidation of enones (such as chalcone) with hydrogen peroxide can be…”
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Conformational Effects on the Electron-Transfer Efficiency in Peptide Foldamers Based on α,α-Disubstituted Glycyl Residues by Gatto, Emanuela, Porchetta, Alessandro, Stella, Lorenzo, Guryanov, Ivan, Formaggio, Fernando, Toniolo, Claudio, Kaptein, Bernard, Broxterman, Quirinus B., Venanzi, Mariano

“…Peptide foldamers based on α,α‐disubstituted glycyl residues were synthesized and chemically characterized to investigate the effects of the electric field…”
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The Family Approach to the Resolution of Racemates by Vries, Ton, Wynberg, Hans, van Echten, Erik, Koek, Jan, ten Hoeve, Wolter, Kellogg, Richard M., Broxterman, Quirinus B., Minnaard, Adri, Kaptein, Bernard, van der Sluis, Sietse, Hulshof, Lumbertus, Kooistra, Jaap

“…The resolution of racemates is revolutionized with the method presented here, in which mixtures (“families”) of structurally and stereochemically related…”
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Molecular spacers for physicochemical investigations based on novel helical and extended peptide structures by Toniolo, Claudio, Crisma, Marco, Formaggio, Fernando, Peggion, Cristina, Broxterman, Quirinus B., Kaptein, Bernard

“…A proper understanding of the detailed nature and mechanism of physicochemical interactions depends heavily upon our ability to design and synthesize…”
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A Peptide Template as an Allosteric Supramolecular Catalyst for the Cleavage of Phosphate Esters by Scarso, Alessandro, Scheffer, Ute, Göbel, Michael, Broxterman, Quirinus B., Kaptein, Bernard, Formaggio, Fernando, Toniolo, Claudio, Scrimin, Paolo

“…The heptapeptide H-Iva-Api-Iva-ATANP-Iva-Api-Iva-NHCH3 (P1a), where Iva is (S)-isovaline, Api is 4-amino-4-carboxypiperidine, and ATANP is…”
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Synthesis of a Stable Helical Peptide and Grafting on Gold Nanoparticles by Pengo, Paolo, Broxterman, Quirinus B, Kaptein, Bernard, Pasquato, Lucia, Scrimin, Paolo

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Configurational Assignment of D- and L-Isovalines in Intact, Natural, and Synthetic Peptides by 2D-NMR Spectroscopy by De Zotti, Marta, Schievano, Elisabetta, Mammi, Stefano, Kaptein, Bernard, Broxterman, Quirinus B., Singh, Sheo B., Brückner, Hans, Toniolo, Claudio

“…We investigated, by means of 2D‐NMR, the naturally occurring and chemically synthesized 16‐mer integramides A and B, which belong to a group of bioactive,…”
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Expanding the Boundaries: Developing a Streamlined Tool for Eco-Footprinting of Pharmaceuticals by Jiménez-González, Concepción, Ollech, Caleb, Pyrz, William, Hughes, David, Broxterman, Quirinus B, Bhathela, Neil

“…The American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable has utilized process mass intensity (PMI) as the key high-level metric to…”
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Diastereoselective Synthesis of (2S,5R)-5-Hydroxypipecolic Acid and 6-Substituted Derivatives by Botman, Peter N. M, Dommerholt, F. Jan, de Gelder, René, Broxterman, Quirinus B, Schoemaker, Hans E, Rutjes, Floris P. J. T, Blaauw, Richard H

“…Herein, we report a diastereoselective synthesis of the natural product (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives thereof. The key step in…”
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Dipeptide-Catalyzed Asymmetric Aldol Condensation of Acetone with (N-Alkylated) Isatins by Luppi, Gianluigi, Cozzi, Pier Giorgio, Monari, Magda, Kaptein, Bernard, Broxterman, Quirinus B, Tomasini, Claudia

“…The aldol condensation of acetone with several isatins is described. The desired compound was obtained in quantitative yield and with good enantioselectivities…”
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A Cross-Metathesis Route to Functionalized α-Methyl α-Substituted Amino Acids by Storcken, Roy P. M., Panella, Lavinia, van Delft, Floris L., Kaptein, Bernard, Broxterman, Quirinus B., Schoemaker, Hans E., Rutjes, Floris P. J. T.

“…A chemoenzymatic approach to the synthesis of functionalized α‐methyl α‐substituted amino acids is detailed. This involves amidase‐mediated enzymatic…”
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Diastereoselective Addition of Allylzinc Bromide to Imines Derived from (R)-Phenylglycine Amide by van der Sluis, Marcel, Dalmolen, Jan, de Lange, Ben, Kaptein, Bernard, Kellogg, Richard M, Broxterman, Quirinus B

“…The highly diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide is reported. Homoallylamines with high enantiomeric…”
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Two-dimensional infrared spectral signatures of 3(10)- and alpha-helical peptides by Maekawa, Hiroaki, Toniolo, Claudio, Broxterman, Quirinus B, Ge, Nien-Hui

“…Two-dimensional infrared (2D IR) spectra of Calpha-alkylated model octapeptides Z-(Aib)8-OtBu, Z-(Aib)5-L-Leu-(Aib)2-OMe, and Z-[L-(alphaMeVal)]8-OtBu have…”
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Two-Dimensional Infrared Spectral Signatures of 310- and α-Helical Peptides by Maekawa, Hiroaki, Toniolo, Claudio, Broxterman, Quirinus B, Ge, Nien-Hui

“…Two-dimensional infrared (2D IR) spectra of Cα-alkylated model octapeptides Z-(Aib)8-OtBu, Z-(Aib)5-l-Leu-(Aib)2-OMe, and Z-[l-(αMeVal)]8-OtBu have been…”
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From Amherst (Massachusetts, USA) to Padua (Italy) and back again: Louis A. Carpino's scientifically productive journey by Toniolo, Claudio, Moretto, Alessandro, Formaggio, Fernando, Broxterman, Quirinus B., Crisma, Marco

“…In this work, we studied and discussed a relevant aspect of peptide science, strictly related to the scientific production of Prof. Louis A. Carpino who passed…”
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