Search Results - "Broxterman, H.J"

Recombinant human endostatin administered as a 28-day continuous intravenous infusion, followed by daily subcutaneous injections: a phase I and pharmacokinetic study in patients with advanced cancer by Hansma, A. H. G., Broxterman, H. J., van der Horst, I., Yuana, Y., Boven, E., Giaccone, G., Pinedo, H. M., Hoekman, K.

“…Background: Endostatin is an endogenous collagen XVIII-fragment with anti-angiogenic properties and remarkable antitumor activity in mice. Preclinical data…”
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ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion by Feller, N., Broxterman, H.J., Währer, D.C.R., Pinedo, H.M.

“…In this study we report that the multidrug resistance protein (MRP) transports calcein from the cytoplasmic compartment of tumor cells, in contrast to…”
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Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein by Hooijberg, J.H, Broxterman, H.J, Heijn, M, Fles, D.L.A, Lankelma, J, Pinedo, H.M

“…The multidrug resistance protein (MRP) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In…”
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Quality Control of Multidrug Resistance Assays in Adult Acute Leukemia: Correlation Between Assays for P-Glycoprotein Expression and Activity by Broxterman, H.J., Sonneveld, P., Feller, N., Ossenkoppele, G.J., Währer, D.C.R., Eekman, C.A., Schoester, M., Lankelma, J., Pinedo, H.M., Löwenberg, B., Schuurhuis, G.J.

“…We have compared multiple assays for the P-glycoprotein (Pgp/MDR1) phenotype in fresh and thawed adult acute leukemia to validate and quantitate measures for…”
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The effect of glutathione on the ATPase activity of MRP1 in its natural membranes by Hooijberg, J.H, Pinedo, H.M, Vrasdonk, C, Priebe, W, Lankelma, J, Broxterman, H.J

“…The transport mechanism by which the multidrug resistance protein 1 (MRP1) effluxes cytotoxic agents out of cells is still not completely understood. However,…”
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How to probe clinical tumour samples for p-glycoprotein and multidrug resistance-associated protein by Broxterman, H.J., Lankelma, J., Pinedo, H.M.

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MDR — Proteins and their clinical relevance by Pinedo, H.M., Lankelma, J., Jansen, G., Broxterman, H.J.

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Multidrug-Resistant Tumor Cells Remain Sensitive to a Recombinant Interleukin-4-Pseudomonas Exotoxin, Except When Overexpressing the Multidrug Resistance Protein MRP1 by DE JONG, Mariska C, SCHEFFER, George L, SCHEPER, Rik J, BROXTERMAN, Henk J, HOOIJBERG, Jan H, SLOOTSTRA, Jerry W, MELOEN, Rob H, KREITMAN, Robert J, HUSAIN, Syed R, JOSHI, Bharat H, PURI, Raj K

“…Tumor cells may become resistant to conventional anticancer drugs through the occurrence of transmembrane transporter proteins such as P-glycoprotein (ABCB1),…”
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Transport proteins in drug resistance: detection and prognostic significance in acute myeloid leukaemia by BROXTERMAN, H.J., SCHUURHUIS, G.J.

“…Resistance to natural product‐derived anti‐cancer drugs, such as the anthracyclines and etoposide, contributes to the failure of chemotherapeutic treatment of…”
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Functional characterization of minimal residual disease in aml - simultaneous detection of p-glycoprotein function and aberrant phenotypes by van der Pol, M.A., Pater, J.M., Feller, N., van Stijn, A., Westra, A.H., Ossenkoppele, G.J., Broxterman, H.J., Schuurhuis, G.J.

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Differentiation dependent expression of P-glycoprotein in the normal and neoplastic human kidney by van Kalken, C K, van der Valk, P, Hadisaputro, M M, Pieters, R, Broxterman, H J, Kuiper, C M, Scheffer, G L, Veerman, A J, Meyer, C J, Scheper, R J

“…Adult renal cell carcinoma (RCC) is clinically resistant to chemotherapy. However, in nephroblastoma (NBL) chemotherapy has increased survival dramatically. We…”
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Drug-transporter proteins in clinical multidrug resistance by Scheper, R J, Broxterman, H J, Scheffer, G L, Meijer, C J, Pinedo, H M

“…Upon exposure to chemotherapeutic drugs, mammalian cells can acquire resistance to structurally and functionally unrelated compounds, a property known as…”
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Daunomycin accumulation in resistant tumor cells as a screening model for resistance modifying drugs: role of protein binding by Broxterman, H J, Kuiper, C M, Schuurhuis, G J, van der Hoeven, J J, Pinedo, H M, Lankelma, J

“…A potential screening system for drugs that modify anthracycline resistance was investigated. The effect of the calcium antagonistic agents verapamil,…”
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Dopamine hypoactivity measured by in vivo voltammetry by Broxterman, H J, Mos, J

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Binding of [3H]flunitrazepam and [3H]spiperone to melanoma cell membrane preparations by Broxterman, H J, Smit, J S, van der Plas, J, van Langevelde, A, Belfroid, R D, van Kempen, G T, van der Krogt, J A

“…Binding of [3H]flunitrazepam and [3H]spiperone to membrane preparations isolated by high speed centrifugation of hamster, rabbit and human melanoma cell…”
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Assay of HA-966 in rat plasma by capillary gas-liquid chromatography with nitrogen-selective detection by Broxterman, H J, Noach, E L, de Vos, D

“…A gas-liquid chromatographic method for the determination of the gamma-aminobutyric acid-like drug 1-hydroxy-3-aminopyrrolidone-2 (HA-966) in plasma is…”
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