Search Results - "Brox, Regine"

Physiologically relevant aspirin concentrations trigger immunostimulatory cytokine production by human leukocytes by Brox, Regine, Hackstein, Holger

“…Acetylsalicylic acid is a globally used non-steroidal anti-inflammatory drug (NSAID) with diverse pharmacological properties, although its mechanism of immune…”
Get full text

Rational design of agonists for bitter taste receptor TAS2R14: from modeling to bench and back by Di Pizio, Antonella, Waterloo, Lukas A. W., Brox, Regine, Löber, Stefan, Weikert, Dorothee, Behrens, Maik, Gmeiner, Peter, Niv, Masha Y.

“…Human bitter taste receptors (TAS2Rs) are a subfamily of 25 G protein-coupled receptors that mediate bitter taste perception. TAS2R14 is the most broadly tuned…”
Get full text

SERPINC1 c.1247dupC: a novel SERPINC1 gene mutation associated with familial thrombosis results in a secretion defect and quantitative antithrombin deficiency by Ruf, Maximilian, Cunningham, Sarah, Wandersee, Alexandra, Brox, Regine, Achenbach, Susanne, Strobel, Julian, Hackstein, Holger, Schneider, Sabine

“…Antithrombin (AT) is an important anticoagulant in hemostasis. We describe here the characterization of a novel AT mutation associated with clinically relevant…”
Get full text

The Chemokine Receptor CXCR3 Isoform B Drives Breast Cancer Stem Cells by Kundu, Namita, Ma, Xinrong, Brox, Regine, Fan, Xiaoxuan, Kochel, Tyler, Reader, Jocelyn, Tschammer, Nuska, Fulton, Amy

“…We are seeking to identify molecular targets that are relevant to breast cancer cells with stem-like properties. There is growing evidence that cancer stem…”
Get full text

Boronic Acids as Probes for Investigation of Allosteric Modulation of the Chemokine Receptor CXCR3 by Bernat, Viachaslau, Admas, Tizita Haimanot, Brox, Regine, Heinemann, Frank W., Tschammer, Nuska

“…The chemokine receptor CXCR3 is a G protein-coupled receptor, which conveys extracellular signals into cells by changing its conformation upon agonist binding…”
Get full text

Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3 by Milanos, Lampros, Brox, Regine, Frank, Theresa, Poklukar, Gašper, Palmisano, Ralf, Waibel, Reiner, Einsiedel, Jürgen, Dürr, Maximilian, Ivanović-Burmazović, Ivana, Larsen, Olav, Hjortø, Gertrud Malene, Rosenkilde, Mette Marie, Tschammer, Nuska

“…In this work we report a design, synthesis, and detailed functional characterization of unique strongly biased allosteric agonists of CXCR3 that contain…”
Get full text

Detection of SARS‐CoV‐2‐independent immunoregulatory activity of COVID‐19 convalescent plasma by Brox, Regine, Achenbach, Susanne, Hackstein, Holger

“…Background Convalescent plasma has emerged as a potential specific treatment for coronavirus disease 2019 (COVID‐19), since it contains severe acute…”
Get full text

Medium supplementation with human, but not fetal calf serum facilitates endocytosis of PLGA nanoparticles by human primary B-lymphocytes via complement opsonization by Pusch, Lennart, Brox, Regine, Cunningham, Sarah, Fischer, Dagmar, Hackstein, Holger

“…The “biological identity” of nanoparticles (NPs) is governed by a shell consisting of various biomolecules that is formed upon exposure to biological media,…”
Get full text

Thrombocyte apheresis cassettes as a novel source of viable peripheral blood mononuclear cells by Cunningham, Sarah, Buchele, Vera, Brox, Regine, Strasser, Erwin, Hackstein, Holger

“…BACKGROUND Traditionally, white blood cells (WBCs) are collected from buffy coats or freshly drawn blood. However, the increasing demand for peripheral blood…”
Get full text

Identifying Modulators of CXC Receptors 3 and 4 with Tailored Selectivity Using Multi-Target Docking by Schmidt, Denis, Bernat, Viachaslau, Brox, Regine, Tschammer, Nuska, Kolb, Peter

“…The G protein-coupled receptors of the C–X–C subfamily form a group among the chemokine receptors whose endogenous ligands are peptides with a common Cys–X–Cys…”
Get full text

The Protein S Erlangen Mutation PROS1c.1904T>C (F635S) Suppresses Secretion by Reißig, Julian, Cunningham, Sarah, Wandersee, Alexandra, Brox, Regine, Achenbach, Susanne, Strobel, Julian, Hackstein, Holger, Schneider, Sabine

“…The recently identified PROS1 mutation Protein S Erlangen c.1904T>C, resulting in amino acid exchange F635S, is associated with severe quantitative protein S…”
Get more information

Discovery of 2‑Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14 by Waterloo, Lukas, Hübner, Harald, Fierro, Fabrizio, Pfeiffer, Tara, Brox, Regine, Löber, Stefan, Weikert, Dorothee, Niv, Masha Y., Gmeiner, Peter

“…The bitter taste receptor TAS2R14 is a G protein-coupled receptor that is found on the tongue as well as in the human airway smooth muscle and other extraoral…”
Get full text

Scavenging of bacteria or bacterial products by magnetic particles functionalized with a broad-spectrum pathogen recognition receptor motif offers diagnostic and therapeutic applications by Friedrich, Bernhard, Lyer, Stefan, Janko, Christina, Unterweger, Harald, Brox, Regine, Cunningham, Sarah, Dutz, Silvio, Taccardi, Nicola, Bikker, Floris J., Hurle, Katrin, Sebald, Heidi, Lenz, Malte, Spiecker, Erdmann, Fester, Lars, Hackstein, Holger, Strauß, Richard, Boccaccini, Aldo R., Bogdan, Christian, Alexiou, Christoph, Tietze, Rainer

“…Sepsis is a dysregulated host response of severe bloodstream infections, and given its frequency of occurrence and high mortality rate, therapeutic…”
Get full text

Development of molecular tools based on the dopamine D3 receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior by Stößel, Anne, Brox, Regine, Purkayastha, Nirupam, Hübner, Harald, Hocke, Carsten, Prante, Olaf, Gmeiner, Peter

“…[Display omitted] Dopamine D3 receptor-mediated networks have been associated with a wide range of neuropsychiatric diseases, drug addiction and food…”
Get full text

Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation by Pusch, Lennart, Brox, Regine, Scheuer, Karl, Yokosawa, Tadahiro, Wu, Mingjian, Zubiri, Benjamin Apeleo, Spiecker, Erdmann, Jandt, Klaus D., Fischer, Dagmar, Hackstein, Holger

“…Poly(lactic-co-glycolic) acid (PLGA) nanoparticles can be prepared by emulsion-solvent-evaporation from o/w and w /o/w emulsions. To elaborate similarities and…”
Get full text

Abstract 4770: Novel CXCR3 allosteric modulators inhibit breast cancer stem cells and metastasis by Kundu, Namita, Brox, Regine, Ma, Xinrong, Reader, Jocelyn, Tschammer, Nuska, Fulton, Amy M.

“…There is an urgent need to identify molecular targets that are relevant to metastatic and/or stem-like cancer cells (CSC). Theoretically, surface-expressed…”
Get full text

Development of molecular tools based on the dopamine D 3 receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior by Stößel, Anne, Brox, Regine, Purkayastha, Nirupam, Hübner, Harald, Hocke, Carsten, Prante, Olaf, Gmeiner, Peter

“…Dopamine D receptor-mediated networks have been associated with a wide range of neuropsychiatric diseases, drug addiction and food maintained behavior, which…”
Get full text

Molecular Mechanisms of Biased and Probe-Dependent Signaling at CXC-Motif Chemokine Receptor CXCR3 Induced by Negative Allosteric Modulators by Brox, Regine, Milanos, Lampros, Saleh, Noureldin, Baumeister, Paul, Buschauer, Armin, Hofmann, Dagmar, Heinrich, Markus R, Clark, Timothy, Tschammer, Nuska

“…Our recent explorations of allosteric modulators with improved properties resulted in the identification of two biased negative allosteric modulators, BD103 (…”
Get more information

Ligand selectivity of a synthetic CXCR4 mimetic peptide by Groß, Andrea, Brox, Regine, Damm, Dominik, Tschammer, Nuška, Schmidt, Barbara, Eichler, Jutta

“…[Display omitted] The chemokine receptor CXCR4 belongs to the family of seven-transmembrane G-protein coupled receptors (GPCRs). It is activated by its natural…”
Get full text

Insight into structural requirements for selective and/or dual CXCR3 and CXCR4 allosteric modulators by Kolarič, Anja, Švajger, Urban, Tomašič, Tihomir, Brox, Regine, Frank, Theresa, Minovski, Nikola, Tschammer, Nuska, Anderluh, Marko

“…Based on the previously published pyrazolopyridine-based hit compound for which negative allosteric modulation of both CXCR3 and CXCR4 receptors was disclosed,…”
Get full text