Search Results - "Brownlie, Rebecca J."

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals by Salmond, Robert J, Brownlie, Rebecca J, Morrison, Vicky L, Zamoyska, Rose

“…The phosphatase PTPN22 is associated with human autoimmune disease. Zamoyska and colleagues demonstrate that loss of PTPN22 enhances T cell responses to weak…”
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Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22 by Brownlie, Rebecca J., Garcia, Celine, Ravasz, Mate, Zehn, Dietmar, Salmond, Robert J., Zamoyska, Rose

“…Transforming growth factor β (TGFβ) is important in maintaining self-tolerance and inhibits T cell reactivity. We show that CD8 + T cells that lack the…”
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Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice by Sood, Shatakshi, Brownlie, Rebecca J, Garcia, Celine, Cowan, Graeme, Salmond, Robert J, Sakaguchi, Shimon, Zamoyska, Rose

“…The cytoplasmic phosphatase, protein tyrosine phosphatase nonreceptor type 22 (PTPN22), is a negative regulator of T cell signaling. Genome-wide association…”
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Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation by Hope, Helen Carrasco, Brownlie, Rebecca J, Fife, Christopher M, Steele, Lynette, Lorger, Mihaela, Salmond, Robert J

“…T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn, facilitates the exit of T cells from quiescence. The increased…”
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T cell receptor signalling networks: branched, diversified and bounded by Brownlie, Rebecca J., Zamoyska, Rose

“…Key Points T cell signalling controls the outcome of T cell receptor (TCR) engagement. That outcome can be either beneficial, for example, by the initiation of…”
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Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion by Teagle, Alexandra Rose, Castro-Sanchez, Patricia, Brownlie, Rebecca J, Logan, Nicola, Kapoor, Simran S, Wright, David, Salmond, Robert J, Zamoyska, Rose

“…BackgroundAdoptive cell therapy (ACT) is a promising strategy for treating cancer, yet it faces several challenges such as lack of long-term protection due to…”
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Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model by Andreou, Tereza, Williams, Jennifer, Brownlie, Rebecca J, Salmond, Robert J, Watson, Erica, Shaw, Gary, Melcher, Alan, Wurdak, Heiko, Short, Susan C, Lorger, Mihaela

“…Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors represents a major therapeutic hurdle. Hematopoietic stem…”
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B cells ferment sugar before they (affinity) mature by Brownlie, Rebecca J., Klein, Ulf

“…Naive B cells activated during infection enter the germinal center (GC) reaction, in which high-affinity antibodies are generated. A new study has uncovered a…”
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Regulation of T Cell Signaling and Immune Responses by PTPN22 by Brownlie, Rebecca J, Salmond, Robert J

“…Protein tyrosine phosphatases (PTPs) play central roles in the regulation of cell signaling, organismal development, cellular differentiation and…”
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Anti–PD-1/anti–CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8⁺ T cell trafficking by Taggart, David, Andreou, Tereza, Scott, Karen J., Williams, Jennifer, Rippaus, Nora, Brownlie, Rebecca J., Ilett, Elizabeth J., Salmond, Robert J., Melcher, Alan, Lorger, Mihaela

“…Inhibition of immune checkpoints programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells results in durable antitumor…”
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Regulation of autoimmune and anti‐tumour T‐cell responses by PTPN22 by Brownlie, Rebecca J., Zamoyska, Rose, Salmond, Robert J.

“…Summary A number of polymorphisms in immune‐regulatory genes have been identified as risk factors for the development of autoimmune disease. PTPN22 (that…”
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Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation by Salmond, Robert J, Brownlie, Rebecca J, Meyuhas, Oded, Zamoyska, Rose

“…Ag-dependent activation of naive T cells induces dramatic changes in cellular metabolism that are essential for cell growth, division, and differentiation. In…”
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Hematopoietic Stem Cell Gene Therapy for Brain Metastases Using Myeloid Cell–Specific Gene Promoters by Andreou, Tereza, Rippaus, Nora, Wronski, Krzysztof, Williams, Jennifer, Taggart, David, Cherqui, Stephanie, Sunderland, Ashley, Kartika, Yolanda D, Egnuni, Teklu, Brownlie, Rebecca J, Mathew, Ryan K, Holmen, Sheri L, Fife, Christopher, Droop, Alastair, Lorger, Mihaela

“…Abstract Background Brain metastases (BrM) develop in 20–40% of cancer patients and represent an unmet clinical need. Limited access of drugs into the brain…”
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Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors by Brownlie, Rebecca J, Wright, David, Zamoyska, Rose, Salmond, Robert J

“…Adoptive T cell therapy (ACT) has been established as an efficacious methodology for the treatment of cancer. Identifying targets to enhance the antigen…”
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Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function by Brownlie, Rebecca J, Miosge, Lisa A, Vassilakos, Demetrios, Svensson, Lena M, Cope, Andrew, Zamoyska, Rose

“…The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase nonreceptor type 22) plays a key role in regulating lymphocyte homeostasis, which ensures that…”
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Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis by Salmond, Robert J, Brownlie, Rebecca J, Zamoyska, Rose

“…The non-receptor tyrosine phosphatase PTPN22 has a vital function in inhibiting antigen-receptor signaling in T cells, while polymorphisms in the PTPN22 gene…”
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FcγRIIb controls bone marrow plasma cell persistence and apoptosis by Smith, Kenneth G C, Xiang, Zou, Cutler, Antony J, Brownlie, Rebecca J, Fairfax, Kirsten, Lawlor, Kate E, Severinson, Eva, Walker, Elizabeth U, Manz, Rudolf A, Tarlinton, David M

“…The survival of long-lived plasma cells, which produce most serum immunoglobulin, is central to humoral immunity. We found here that the inhibitory Fc receptor…”
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Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity by Burn, Garth L, Cornish, Georgina H, Potrzebowska, Katarzyna, Samuelsson, Malin, Griffié, Juliette, Minoughan, Sophie, Yates, Mark, Ashdown, George, Pernodet, Nicolas, Morrison, Vicky L, Sanchez-Blanco, Cristina, Purvis, Harriet, Clarke, Fiona, Brownlie, Rebecca J, Vyse, Timothy J, Zamoyska, Rose, Owen, Dylan M, Svensson, Lena M, Cope, Andrew P

“…Integrins are heterodimeric transmembrane proteins that play a fundamental role in the migration of leukocytes to sites of infection or injury. We found that…”
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Distinct cell-specific control of autoimmunity and infection by FcγRIIb by Brownlie, Rebecca J., Lawlor, Kate E., Niederer, Heather A., Cutler, Antony J., Xiang, Zou, Clatworthy, Menna R., Floto, R. Andres, Greaves, David R., Lyons, Paul A., Smith, Kenneth G.C.

“…FcγRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or…”
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Regulation of allograft survival by inhibitory FcγRIIb signaling by Callaghan, Chris J, Win, Thet Su, Motallebzadeh, Reza, Conlon, Thomas M, Chhabra, Manu, Harper, Inês, Sivaganesh, Siva, Bolton, Eleanor M, Bradley, J Andrew, Brownlie, Rebecca J, Smith, Kenneth G C, Pettigrew, Gavin J

“…Fcγ receptors (FcγR) provide important immunoregulation. Targeting inhibitory FcγRIIb may therefore prolong allograft survival, but its role in transplantation…”
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