Search Results - "Brownlee, Robert T. C."

Effect of atomic charge, solvation, entropy, and ligand protonation state on MM-PB(GB)SA binding energies of HIV protease by Oehme, Daniel P., Brownlee, Robert T. C., Wilson, David J. D.

“…The molecular mechanics‐Poisson‐Boltzmann surface area (MM‐PBSA) and MM‐generalized‐Born surface area (MM‐GBSA) approaches are commonly used in molecular…”
Get full text

Synthetic Preparation of N-Methyl-α-amino Acids by Aurelio, Luigi, Brownlee, Robert T. C, Hughes, Andrew B

“…Amino acids are incorporated in proteins, peptides, enzymes, hormones and an enormous array of secondary metabolites. Aurelio et al describe methods for the…”
Get full text

Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide by Ankers, Elizabeth A, Evison, Benny J, Phillips, Don R, Brownlee, Robert T C, Cutts, Suzanne M

“…A novel derivative of the anti-tumor agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) was prepared by reduction of 9-oxoacridan-4-carboxylic acid…”
Get full text

An Efficient Synthesis of N-Methyl Amino Acids by Way of Intermediate 5-Oxazolidinones by Aurelio, Luigi, Box, John S, Brownlee, Robert T. C, Hughes, Andrew B, Sleebs, Marianne M

“…N-Methyl amino acids occur in many natural products. Experimental strategies are presented for a unified approach to the synthesis of N-methyl derivatives…”
Get full text

Effect of Structural Stress on the Flexibility and Adaptability of HIV-1 Protease by Oehme, Daniel P., Wilson, David J. D., Brownlee, Robert T. C.

“…Resistance remains a major issue with regards to HIV-1 protease, despite the availability of numerous HIV-1 protease inhibitors and copious amounts of…”
Get full text

Binding of an RNA pol II Ligand to the WW Domain of Pin1 Using Molecular Dynamics Docking Simulations by Ng, Chai Ann, Oehme, Daniel P, Kato, Yusuke, Tanokura, Masaru, Brownlee, Robert T. C

“…A novel docking protocol using a long, all atom molecular dynamics (MD) simulation, in an explicit solvent medium, without using any distance constraints is…”
Get full text

A Novel Synthesis of N-Methyl Asparagine, Arginine, Histidine, and Tryptophan by Aurelio, Luigi, Brownlee, Robert T. C, Hughes, Andrew B

“…N-Methyl amino acid residues in peptides modify several pharmacologically useful parameters, but synthesis of alkylated peptides is hampered by unavailability…”
Get full text

PinA from Aspergillus nidulans binds to pS/pT-P motifs using the same Loop I and XP groove as mammalian Pin1 by Kato, Yusuke, Ng, Chai Ann, Brownlee, Robert T.C., Tanokura, Masaru

“…Binding of the Cdc25c-T48 ligand to PinA from Aspergillus nidulans has been characterised by the identification of 15N and 1H resonances from 1H– 15N HSQC NMR…”
Get full text

A total synthesis of a highly N-methylated cyclodepsipeptide [2S,3S-Hmp]-aureobasidin L using solid-phase methods by Maharani, Rani, Brownlee, Robert T.C., Hughes, Andrew B., Abbott, Belinda M.

“…[2S,3S-Hmp]-Aureobasidin L 2 has been successfully synthesised through a combination of solution- and solid-phase peptide synthesis. All of the Fmoc-protected…”
Get full text

Can cyclic HIV protease inhibitors bind in a non-preferred form? An ab initio, DFT and MM-PB(GB)SA study by Oehme, Daniel P., Brownlee, Robert T. C., Wilson, David J. D.

“…X-ray crystallography studies have identified that most cyclic inhibitors of HIV protease (including cyclic ureas) bind in a symmetric manner, however some…”
Get full text

A convenient gram-scale synthesis of uridine diphospho( 13C 6)glucose by Dinev, Zoran, Wardak, Ahmad Z., Brownlee, Robert T.C., Williams, Spencer J.

“…A simple gram-scale synthesis of uridine diphospho( 13C 6)glucose is presented from d-( 13C 6)glucose. The critical step uses a 1 H-tetrazole-catalyzed…”
Get full text

Structural characterisation of PinA WW domain and a comparison with other Group IV WW domains, Pin1 and Ess1 by Ng, Chai Ann, Kato, Yusuke, Tanokura, Masaru, Brownlee, Robert T.C.

“…The NMR solution structure of the PinA WW domain from Aspergillus nidulans is presented. The backbone of the PinA WW domain is composed of a triple-stranded…”
Get full text

Characterisation of the extracellular polysaccharides produced by isolates of the fungus Acremonium by Schmid, Frank, Separovic, Frances, McDougall, Barbara M., Stone, Bruce A., Brownlee, Robert T.C., Seviour, Robert J.

“…Solid state 13C NMR studies and enzymatic digestion of the extracellular glucans from the fungi Acremonium persicinum C38 (QM107a) and Acremonium sp. strain…”
Get full text

Solvent affects the conformation of virginiamycin M1 (pristinamycin IIA, streptogramin A) by Dang, Jason, Bergdahl, Mikael, Separovic, Frances, Brownlee, Robert T C, Metzger, Robert P

“…The streptogramins are antibiotics which act by binding two different components at separate nearby sites on the bacterial 50S ribosome, inhibiting protein…”
Get more information

Solution structures by NMR of a novel antifungal drug: Petriellin A by Dang, Jason, Aurelio, Luigi, Hughes, Andrew B, Brownlee, Robert T C

“…Petriellin A is a novel cyclic depsipeptide antifungal compound consisting of nine l-configured residues, one d-phenyllactic acid (PhLac) and three unknown…”
Get more information

An FcγRIIa-binding peptide that mimics the interaction between FcγRIIa and IgG by Cendron, Angela C., Wines, Bruce D., Brownlee, Robert T.C., Ramsland, Paul A., Pietersz, Geoffrey A., Hogarth, P. Mark

“…A disulphide-constrained peptide that binds to the low affinity Fc receptor, FcγRIIa (CD32) has been identified and its structure solved by NMR. Linear (7-mer…”
Get full text

The conformational flexibility of the antibiotic virginiamycin M1 by Dang, Jason, Metzger, Robert P., Brownlee, Robert T. C., Ng, Chai Ann, Bergdahl, Mikael, Separovic, Frances

“…The antibiotic virginiamycin is a combination of two molecules, virginiamycin M^sub 1^ (VM1) and virginiamycin S^sub 1^ (VS1) or analogues, which function…”
Get full text

Systematic Electrochemical Synthesis of Reduced Forms of the alpha-[S(2)Mo(18)O(62)](4)(-) Anion by Way, David M., Cooper, John B., Sadek, Maruse, Vu, Truc, Mahon, Peter J., Bond, Alan M., Brownlee, Robert T. C., Wedd, Anthony G.

Get full text

Para-substituent C-13 chemical shifts in substituted benzenes. 1. Updating the .sigma.R0 scale and analysis of aprotic solvent effects by Bromilow, John, Brownlee, Robert T. C, Lopez, Vega O, Taft, Robert W

Get full text

Nonadditive carbon-13 nuclear magnetic resonance substituent shifts in 1,4-disubstituted benzenes. Nonlinear resonance and shift-charge ratio effects by Bromilow, John, Brownlee, Robert T. C, Craik, David J, Sadek, Maruse, Taft, Robert W

Get full text