Search Results - "Brownlee, M"

Biochemistry and molecular cell biology of diabetic complications by Brownlee, Michael

“…Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to…”
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BAF180 promotes cohesion and prevents genome instability and aneuploidy by Brownlee, Peter M, Chambers, Anna L, Cloney, Ross, Bianchi, Alessandro, Downs, Jessica A

“…BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether…”
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Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice by McMurray, K.M.J., Du, X., Brownlee, M., Palmer, A.A.

“…•Mice overexpressing Glo1 only in neurons showed increased anxiety-like behavior.•Microinjection of MG, the substrate for Glo1, into BLA reduced anxiety-like…”
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Negative consequences of glycation by Brownlee, Michael

“…The Diabetes Control and Complications Trial (DCCT) established unequivocally that the effects of inadequate insulin action (as monitored by the level of…”
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The Role of the Versius Surgical Robotic System in the Paediatric Population by Brownlee, Ewan M, Slack, Mark

“…The uptake of robot-assisted surgery has continuously grown since its advent in the 1990s. While robot-assisted surgery is well-established in adult surgery,…”
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Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes by Du, X, Edelstein, D, Brownlee, M

“…Aims/hypothesis We determined whether fixed doses of benfotiamine in combination with slow-release α-lipoic acid normalise markers of reactive oxygen…”
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Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology by Berner, A. K., Brouwers, O., Pringle, R., Klaassen, I., Colhoun, L., McVicar, C., Brockbank, S., Curry, J. W., Miyata, T., Brownlee, M., Schlingemann, R. O., Schalkwijk, C., Stitt, A. W.

“…Aims/hypothesis Methylglyoxal (MG) is an important precursor for AGEs. Normally, MG is detoxified by the glyoxalase (GLO) enzyme system (including component…”
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Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress by Brouwers, O, Niessen, P. M, Haenen, G, Miyata, T, Brownlee, M, Stehouwer, C. D, De Mey, J. G, Schalkwijk, C. G

“…Aims/hypothesis Impaired nitric oxide (NO)-dependent vasorelaxation plays a key role in the development of diabetic vascular complications. We investigated the…”
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'I'd like to be just a bit closer': wildlife viewing proximity preferences at Denali National Park & Preserve by Verbos, R. I., Zajchowski, C. A. B., Brownlee, M. T. J., Skibins, J. C.

“…Proximity, the physical distance between visitors and wildlife, has been suggested as a potential factor contributing to high-quality wildlife viewing…”
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The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses by Chambers, Anna L, Brownlee, Peter M, Durley, Samuel C, Beacham, Tracey, Kent, Nicholas A, Downs, Jessica A

“…The RSC chromatin remodeling complex has been implicated in contributing to DNA double-strand break (DSB) repair in a number of studies. Both survival and…”
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The missing link: A single unifying mechanism for diabetic complications by Nishikawa, Takeshi, Edelstein, Diane, Brownlee, Michael

“…The missing link: A single unifying mechanism for diabetic complications. A causal relationship between chronic hyperglycemia and diabetic microvascular…”
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Glycation products and the pathogenesis of diabetic complications by BROWNLEE, M

“…Glycation products and the pathogenesis of diabetic complications. M Brownlee Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York…”
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Neurocognitive outcomes in adults following cerebral hypoxia: A systematic literature review by Brownlee, Naomi N M, Wilson, F Colin, Curran, David B, Lyttle, Nigel, McCann, John P

“…Hypoxic ischemic brain injury (HIBI) occurs as a result of complete or partial disruption of cerebral oxygen supply. The physical and cognitive sequelae of…”
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Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells by SRINIVASAN, S, HATLEY, M. E, BOLICK, D. T, PALMER, L. A, EDELSTEIN, D, BROWNLEE, M, HEDRICK, C. C

“…Hyperglycaemia is a primary cause of vascular complications in diabetes. A hallmark of these vascular complications is endothelial cell dysfunction, which is…”
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Better understanding the downsides of low value healthcare could reduce harm by Brownlee, Shannon M, Korenstein, Deborah

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Structure of the Ferrous Form of (4-Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis in Complex with the Therapeutic Herbicide, NTBC by Brownlee, June M, Johnson-Winters, Kayunta, Harrison, David H. T, Moran, Graham R

“…Di- and triketone inhibitors of (4-hydroxyphenyl)pyruvate dioxygenase (HPPD) are both effective herbicides and therapeutics. The inhibitory activity is used to…”
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Inositols Prevent and Reverse Endothelial Dysfunction in Diabetic Rat and Rabbit Vasculature Metabolically and by Scavenging Superoxide by Nascimento, N. R. F., Lessa, L. M. A., Kerntopf, M. R., Sousa, C. M., Alves, R. S., Queiroz, M. G. R., Price, J., Heimark, D. B., Larner, J., Du, X., Brownlee, M., Gow, A., Davis, C., Fonteles, M. C.

“…Endothelial dysfunction (ED) is an early feature of cardiovascular risk and diabetes. Hyperglycemia and hyperlipidemia are causative factors. Excessive…”
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Cancer and the bromodomains of BAF180 by Brownlee, Peter M, Chambers, Anna L, Oliver, Antony W, Downs, Jessica A

“…Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene…”
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Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy by Lin, J, Bierhaus, A, Bugert, P, Dietrich, N, Feng, Y, Vom Hagen, F, Nawroth, P, Brownlee, M, Hammes, H-P

“…Hyperglycaemia-induced mitochondrial overproduction of reactive oxygen species (ROS) is central to the pathogenesis of endothelial damage in diabetes…”
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Analysis of charge-pump phase-locked loops by Hanumolu, P.K., Brownlee, M., Mayaram, K., Un-Ku Moon

“…In this paper, we present an exact analysis for third-order charge-pump phase-locked loops using state equations. Both the large-signal lock acquisition…”
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