Search Results - "Browning, Michael D"

Radiation induces acute alterations in neuronal function by Wu, Peter H, Coultrap, Steven, Pinnix, Chelsea, Davies, Kurtis D, Tailor, Ramesh, Ang, Kian K, Browning, Michael D, Grosshans, David R

“…Every year, nearly 200,000 patients undergo radiation for brain tumors. For both patients and caregivers the most distressing adverse effect is impaired…”
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Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures by Bernard, Paul B, Castano, Anna M, O'Leary, Heather, Simpson, Kameron, Browning, Michael D, Benke, Tim A

“…Abstract Outside of Fragile X syndrome (FXS), the role of Fragile-X Mental Retardation Protein (FMRP) in mediating neuropsychological abnormalities is not…”
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Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase by Hicklin, Tianna R, Wu, Peter H, Radcliffe, Richard A, Freund, Ronald K, Goebel-Goody, Susan M, Correa, Paulo R, Proctor, William R, Lombroso, Paul J, Browning, Michael D

“…Alcohol's deleterious effects on memory are well known. Acute alcohol-induced memory loss is thought to occur via inhibition of NMDA receptor (NMDAR)-dependent…”
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A Hippocampal NR2B Deficit Can Mimic Age-Related Changes in Long-Term Potentiation and Spatial Learning in the Fischer 344 Rat by Clayton, Daniel A, Mesches, Michael H, Alvarez, Enriquez, Bickford, Paula C, Browning, Michael D

“…Aged rats are known to have deficits in spatial learning behavior in the Morris water maze. We have found that aged rats also have deficits in NR2B protein…”
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Top Five Considerations When Choosing an Antibody by Archuleta, Amy, Browning, Michael D

“…The choice of an antibody for a protein-based research study is one of the most crucial steps in any project. Seemingly straightforward, the process is…”
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Should we ignore western blots when selecting antibodies for other applications? by Lund-Johansen, Fridtjof, Browning, Michael D

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Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor by Grosshans, David R., Browning, Michael D.

“…The N‐methyl‐d‐aspartate receptor (NMDAR) is an ionotropic glutamate receptor, which plays crucial roles in synaptic plasticity and development. We have…”
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Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis by Nayak, Asha, Zastrow, Devon J, Lickteig, Ronald, Zahniser, Nancy R, Browning, Michael D

“…Long-term potentiation (LTP) is a form of synaptic plasticity that has been extensively studied as a putative mechanism underlying learning and memory. A late…”
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Aging and Surface Expression of Hippocampal NMDA Receptors by Clayton, Daniel A., Grosshans, David R., Browning, Michael D.

“…Aging is known to alter many physiological processes within the brain including synaptic responses, long-term potentiation, learning, and memory. Aging has…”
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Tyrosine Dephosphorylation and Ethanol Inhibition of N-Methyl-d-aspartate Receptor Function by Alvestad, Rachel M, Grosshans, David R, Coultrap, Steven J, Nakazawa, Takanobu, Yamamoto, Tadashi, Browning, Michael D

“…The inhibitory effect of ethanol on N -methyl- d -aspartate receptors (NMDARs) is well documented in several brain regions. However, the molecular mechanisms…”
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A single episode of neonatal seizures permanently alters glutamatergic synapses by Cornejo, Brandon J., Mesches, Michael H., Coultrap, Steven, Browning, Michael D., Benke, Timothy A.

“…Objective The contribution of seizures to cognitive changes remains controversial. We tested the hypothesis that a single episode of neonatal seizures (sNS) on…”
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Differential expression of NMDA receptor subunits and splice variants among the CA1, CA3 and dentate gyrus of the adult rat by Coultrap, Steven J., Nixon, Kristin M., Alvestad, Rachel M., Fernando Valenzuela, C., Browning, Michael D.

“…N-Methyl- d-aspartate (NMDA)-type glutamate receptors in the hippocampus are important mediators of both memory formation and excitotoxicity. It is thought…”
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Tyrosine phosphorylation of the N-methyl- d-aspartate receptor is enhanced in synaptic membrane fractions of the adult rat hippocampus by Goebel, Susan M., Alvestad, Rachel M., Coultrap, Steven J., Browning, Michael D.

“…Hippocampal N-methyl- d-aspartate receptors (NMDARs) contribute to the expression of certain types of synaptic plasticity, such as long-term potentiation…”
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Regionally selective alterations in expression of the α1D subunit (Cav1.3) of L-type calcium channels in the hippocampus of aged rats by VENG, Lone M, BROWNING, Michael D

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Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption by Wu, Peter H, Coultrap, Steven, Browning, Michael D, Proctor, William R

“…J. Neurochem. (2010) 115, 1112-1122. ABSTRACT: Alcohol abuse leads to tolerance, dependence, and memory impairments that involve excitatory glutamatergic NMDA…”
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Functional adaptation of the N-methyl-D-aspartate receptor to inhibition by ethanol is modulated by striatal-enriched protein tyrosine phosphatase and p38 mitogen-activated protein kinase by Wu, Peter H, Coultrap, Steven J, Browning, Michael D, Proctor, William R

“…The hippocampal N-methyl-D-aspartate receptor (NMDAR) activity plays important roles in cognition and is a major substrate for ethanol-induced memory…”
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Long Term Synaptic Depression That Is Associated with GluR1 Dephosphorylation but Not α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Internalization by Davies, Kurtis D., Goebel-Goody, Susan M., Coultrap, Steven J., Browning, Michael D.

“…Long lasting changes in the strength of synaptic transmission in the hippocampus are thought to underlie certain forms of learning and memory. Accordingly, the…”
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Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation by Thoemmes, Stephen F., Stutzke, Crystal A., Du, Yanmei, Browning, Michael D., Buttrick, Peter M., Walker, Lori A.

“…Phosphorylation of cardiac troponin I is a well established mechanism by which cardiac contractility is modulated. However, there are a number of…”
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Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP by Coultrap, Steven J, Bickford, Paula C, Browning, Michael D

“…NMDA receptor-dependent long-term potentiation (LTP) in the hippocampus is widely accepted as a cellular substrate for memory formation. Age-related declines…”
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Sulindac improves memory and increases NMDA receptor subunits in aged Fischer 344 rats by Mesches, Michael H., Gemma, Carmelina, Veng, Lone M., Allgeier, Chrissy, Young, David A., Browning, Michael D., Bickford, Paula C.

“…Inflammatory processes in the central nervous system are thought to contribute to Alzheimer’s disease (AD). Chronic administration of nonsteroidal…”
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