Search Results - "Browning, Carrie F."

Discovery of Tricyclic Indoles That Potently Inhibit Mcl‑1 Using Fragment-Based Methods and Structure-Based Design by Burke, Jason P, Bian, Zhiguo, Shaw, Subrata, Zhao, Bin, Goodwin, Craig M, Belmar, Johannes, Browning, Carrie F, Vigil, Dominico, Friberg, Anders, Camper, DeMarco V, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

“…Myeloid cell leukemia-1 (Mcl-1) is an antiapoptotic member of the Bcl-2 family of proteins that is overexpressed and amplified in many cancers. Overexpression…”
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Discovery and biological characterization of potent myeloid cell leukemia‐1 inhibitors by Lee, Taekyu, Bian, Zhiguo, Zhao, Bin, Hogdal, Leah J., Sensintaffar, John L., Goodwin, Craig M., Belmar, Johannes, Shaw, Subrata, Tarr, James C., Veerasamy, Nagarathanam, Matulis, Shannon M., Koss, Brian, Fischer, Melissa A., Arnold, Allison L., Camper, DeMarco V., Browning, Carrie F., Rossanese, Olivia W., Budhraja, Amit, Opferman, Joseph, Boise, Lawrence H., Savona, Michael R., Letai, Anthony, Olejniczak, Edward T., Fesik, Stephen W.

“…Myeloid cell leukemia 1 (Mcl‐1) is an antiapoptotic member of the Bcl‐2 family of proteins that when overexpressed is associated with high tumor grade, poor…”
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Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS by Abbott, Jason R, Patel, Pratiq A, Howes, Jennifer E, Akan, Denis T, Kennedy, J. Phillip, Burns, Michael C, Browning, Carrie F, Sun, Qi, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, Fesik, Stephen W

“…Proteins in the RAS family are important regulators of cellular signaling and, when mutated, can drive cancer pathogenesis. Despite considerable effort over…”
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Abstract 3551: Discovery of orally bioavailable novel Mcl-1 inhibitors that exhibit selective anti-proliferative activity in Mcl-1 sensitive cancer cell lines by Lee, Taekyu, Bian, Zhiguo, Belmar, Johannes, Shaw, Subrata, Tarr, James C., Zhao, Bin, Pelz, Nick, Camper, DeMarco, Goodwin, Craig M., Arnold, Allison L., Sensintaffar, John L., Browning, Carrie F., Rossanese, Olivia W., Olejniczak, Edward T., Fesik, Stephen W.

“…Abstract Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that regulate apoptosis. Amplification of Mcl-1 is found in various…”
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Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A by Patrone, James D., Pelz, Nicholas F., Bates, Brittney S., Souza-Fagundes, Elaine M., Vangamudi, Bhavatarini, Camper, Demarco V., Kuznetsov, Alexey G., Browning, Carrie F., Feldkamp, Michael D., Frank, Andreas O., Gilston, Benjamin A., Olejniczak, Edward T., Rossanese, Olivia W., Waterson, Alex G., Chazin, Walter J., Fesik, Stephen W.

“…Replication protein A (RPA) is an essential single‐stranded DNA (ssDNA)‐binding protein that initiates the DNA damage response pathway through protein–protein…”
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Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication ProteinA by Patrone, James D, Pelz, Nicholas F, Bates, Brittney S, Souza-Fagundes, Elaine M, Vangamudi, Bhavatarini, Camper, Demarco V, Kuznetsov, Alexey G, Browning, Carrie F, Feldkamp, Michael D, Frank, Andreas O, Gilston, Benjamin A, Olejniczak, Edward T, Rossanese, Olivia W, Waterson, Alex G, Chazin, Walter J, Fesik, Stephen W

“…Replication proteinA (RPA) is an essential single-stranded DNA (ssDNA)-binding protein that initiates the DNA damage response pathway through protein-protein…”
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Four and a half LIM protein 1: a partner for KCNA5 in human atrium by Yang, Zhenjiang, Browning, Carrie F., Hallaq, Haifa, Yermalitskaya, Liudmila, Esker, Jan, Hall, Matthew R., Link, Andrew J., Ham, Amy-Joan L., McGrath, Meagan J., Mitchell, Christina A., Murray, Katherine T.

“…Aims Protein–protein interactions are critical for the normal membrane trafficking, localization, and function of voltage-gated ion channels. In human heart,…”
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Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors by Lee, Taekyu, Bian, Zhiguo, Zhao, Bin, Hogdal, Leah J., Sensintaffar, John L., Goodwin, Craig M., Belmar, Johannes, Shaw, Subrata, Tarr, James C., Veerasamy, Nagarathanam, Matulis, Shannon M., Koss, Brian, Fischer, Melissa A., Arnold, Allison L., Camper, DeMarco V., Browning, Carrie F., Rossanese, Olivia W., Budhraja, Amit, Opferman, Joseph, Boise, Lawrence H., Savona, Michael R., Letai, Anthony, Olejniczak, Edward T., Fesik, Stephen W.

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